Department of Cardiovascular Sciences


Nephrology research in Leicester is carried out by a team of clinical and non-clinical academics from both University and NHS backgrounds.

Topics of interest encompass laboratory, clinical and epidemiological studies in kidney disease. The renal labs have a strong track record of research into the cell biology of proteinuric renal disease, tubular injury, IgA nephropathy, diabetic nephropathy and the mechanisms of progressive renal injury. Urinary proteomics and advanced urinary diagnostics are a major new focus. A large programme of research in primary care examines the effects of education on blood pressure control, and disease management programmes on progression and outcomes in chronic kidney disease. These studies are partly supported through CLAHRC-LNR.

Nephrology group

Professor Nigel Brunskill

Mechanisms of progressive renal disease and diabetic nephropathy. Study of novel biomarkers of cardiovascular disease in uraemia. Urinary protoemic and diagnostics. Clinical studies into renal disease and its complications in pregnancy.

Dr Kevin Harris

Pathogeneisis of glomerulosclerosis in progressive renal failure. 

Dr Jonathan Barratt

Immunopathogenesis of IgA nephropathy. Urine proteomics and novel biomarker discovery in renal and non-renal disease.

Dr Peter Topham

Pathogenesis of proteinuria.

Dr Alan Bevington

The metabolic basis of catabolic states, in particular the stimulation of protein wasting in skeletal muscle in response to metabolic acidosis. 

Dr James Burton

Cardiovascular diseases and risk in patients with chronic kidney disease.

Professor Alice Smith

Lifestyle management in chronic kidney disease; impact of lifestyle interventions on muscle health, inflammation and immune function; patient perspectives and experience; patient involvement and engagement in research.

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