Research involving the use of animals

The University of Leicester’s strategy is to deliver world-leading research that transforms lives.  Research conducted at the University contributes to the furthering of knowledge of the biological and chemical mechanisms by which life originates and is sustained and reproduced. This research has made, and continues to make, a vital contribution to the understanding, treatment and cure of a range of health problems and diseases including cancer, heart disease, kidney disease, and infectious diseases such as meningitis, diabetes and respiratory disease. Much of this research can be carried out using non-animal methods and materials, such as computer models and in-vitro technologies and this is always the preferred method when these replacement technologies exist. Whilst it is acknowledged that the animal model is not a perfect model for humans, currently the use of animals in biomedical research remains essential in many cases, for example to gain a knowledge and understanding of some cell structures and physiological and pathological processes. Alternative techniques cannot always reproduce the complexity of a living creature. Sometimes animals must be used to assess the safety and efficacy of new treatment regimens before these treatments are translated into humans. The University supports the view that good science is equated with humane science, and we constantly strive to ensure our animals are cared for to the highest of standards. Many of the developments achieved through the use of animals have also benefited animals, helping them to live longer and healthier lives.

The University’s use of animals in research is guided by the following principles:

• The University is committed to the principles of Reduction, Refinement and Replacement (3Rs). 
  • Animals are only used in research programs where there are no alternatives. Researchers are asked to justify what non-animal methods have been considered and why they cannot be used
  • The minimum number of animals consistent with the objectives of the research will be used, as determined by statistical calculations where appropriate
  • Procedures used will always seek to operate as the minimal level of severity possible
• All work under the Animals (Scientific Procedures) Act 1986 (ASPA) involving animals is carried out under licences issued by the Home Office. Licences are issued after a detailed harm benefit analysis has been undertaken by the Home Office, of the potential benefits of the work compared with the possible adverse effects on the animals.
• The University’s use of animals is scrutinised by AWERB which includes lay representation (including members external to the University).
• All work involving animals that is not covered under ASPA also receives internal scrutiny at our Animal Welfare and Ethical Review Board (AWERB) through our non-regulated process to ensure a robust harm benefit analysis.
• AWERB assesses all new licence applications, reviews the progress on licences that have been approved by the Home Office and monitors and inspects the standards of animal care, welfare and accommodation within the University. AWERB monitors that those working with animals are aware of their responsibilities and receive appropriate training and continuing professional development.
• The University is committed to maintaining high standards of laboratory animal housing and care and believes this makes a vital contribution to the quality of the research. The animal facility  complies with and often exceeds all standards set out in all national laws, guidelines and Code of Practice.
• The results of research which has involved the use of animals is regularly published where possible to advance knowledge, disseminate good practice and minimise the requirement for other scientists to undertake similar work elsewhere.
• Scientists, technicians and veterinarians who deal with the animals on a daily basis, care about the wellbeing of animals. All staff involved in animal research are trained to standards which are approved by recognised professional bodies and which adhere to national standards. The University supervises all staff appropriately and provides suitable facilities so that staff can carry out their duties responsibly and humanely. Named Veterinary Surgeons (NVS) are available at all times for advice and help on the welfare of animals and the conduct of research.
• The University is committed to a Culture of Care that extends beyond consideration of animal experimentation alone and ensures animals and those caring for them are treated with compassion, empathy and respect.