The PERFORM trial

Publications

Some of these publications are also available in plain English summaries.

The complexity of outcome measure selection within multiple long-term condition research: an analysis of exercise-based rehabilitation trials, James Manifield, Rachael Evans, Susan Smith, Anne Holland, Søren Skou, Rod Taylor & Sally Singh, Trials 27, 46 (2026). doi: 10.1186/s13063-025-09363-y 

Personalised exercise-rehabilitation FOR people with multiple long-term conditions (PERFORM): a new paradigm for rehabilitation provision? Rod S Taylor, Grace Dibben, Frances Mair, Bhautesh Jani, Sharon Simpson, Sally J Singh, on behalf of the PERFORM collaboration, Heart 2025;111:A1-A2. doi: 10.1136/heartjnl-2025-BACPR.3 

Co-design and development of a Personalised Exercise-based Rehabilitation and self-management programme FOR people with Multiple long-term conditions: The PERFORM intervention, Paulina Daw, Colin J. Greaves, Nikki Gardiner, Patrick Doherty, Thomas M. Withers, Amy C. Barradell, Paul O’Halloran, Zahira Ahmed, Shaun Barber, Gwen Barwell, Sophie E. Brown, Sarah Dean10, Carlos Echevarria, Rachael A. Evans, Tracy Ibbotson, Bhautesh D. Jani, Kate Jolly, James R. Manifield, Frances S. Mair, Emma McIntosh, Daniel Miller, Paula Ormandy, Susan M. Smith, Sharon A. Simpson, Ghazala Waheed, Rod S. Taylor, Sally J. Singh, and on behalf of the PERFORM research team, Journal of Multimorbidity and Comorbidity. 2025;15. doi: 10.1177/26335565251367326

Personalised Exercise Rehabilitation FOR people with Multiple long-term conditions (PERFORM): findings from a process evaluation of a randomised feasibility study, Sophie Eleanor Brown, Sharon Simpson, Colin Greaves, Paulina Daw, Sarah Dean, Rachael Evans, Thomas M Withers, Zahira Ahmed, Shaun Barber, Gwen Barwell, Patrick Doherty, Nikki Gardiner, Tracy Ibbotson, Bhautesh Jani, Kate Jolly, Frances S Mair, James Manifield, Emma McIntosh, Dan Miller, Paula Ormandy, Susan Smith, Ioannis Vogiatzis, Ghazala Waheed, Rod Taylor, Sally Singh, and on behalf of the PERFORM research team, BMJ Open 2025;15:e100199. doi: 10.1136/bmjopen-2025-100199 

Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (PERFORM): a randomised feasibility study, Rachael A Evans, Sharon A Simpson, James R Manifield, Zahira Ahmed, Shaun Barber, Gwen Barwell, Sophie Eleanor Brown, Paulina Daw, Sarah G Dean, Patrick J Doherty, Heather L Fraser, Nikki Gardiner, Colin Greaves, Tracy Ibbotson, Bhautesh D Jani, Kate Jolly, Frances S Mair, Emma McIntosh, Dimitrios Megaritis, Dan Miller, Paula Ormandy, Susan M Smith, Ioannis Vogiatzis, Ghazala Waheed, Thomas M Withers, Rod S Taylor, Sally J Singh, and on behalf of PERFORM research team, BMJ Open 2025;15:e100195. doi: 10.1136/bmjopen-2025-100195

Protocol for the development and validation of a Core Set for exercise-based rehabilitation of adults with multiple long-term conditions (multimorbidity) based on the World Health Organization’s International Classification of Functioning, Disability, and Health (ICF) framework, Bickton FM, Manifield JR, Limbani F, Justin Dixon, Anne E. Holland, Rod S. Taylor, Claire Calderwood, Walter Wittich, Celia L. Gregson, Martin Heine, Zahira Ahmed, Ronel Roos, Sally J. Singh and the Africa Multimorbidity Alliance – Multimorbidity Rehabilitation Working Group, Journal of Multimorbidity and Comorbidity, May 20, 2025;15.doi:10.1177/26335565251343923 https://journals.sagepub.com/doi/full/10.1177/26335565251343923

Personalised Exercise-rehabilitation for People with Multiple Long-term Conditions (PERFORM): A Randomised Feasibility Study [abstract]. R.A. Evans, J. Manifield, S.A. Simpson, C. Greaves, S. Barber, G. Waheed, G. Barwell, N. Gardiner, D. Miller, I. Vogiatzis, R. Taylor, and S.J. Singh. Am J Respir Crit Care Med 2025;211:A1041 https://www.atsjournals.org/doi/abs/10.1164/ajrccm.2025.211.Abstracts.A1041

Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts, Lewis Steell, Stefanie J. Krauth, Sayem Ahmed, Grace O. Dibben, Emma McIntosh, Peter Hanlon, Jim Lewsey, Barbara I. Nicholl, David A. McAllister, Susan M. Smith, Rachael Evans, Zahira Ahmed, Sarah Dean, Colin Greaves, Shaun Barber, Patrick Doherty, Nikki Gardiner, Tracy Ibbotson, Kate Jolly, Paula Ormandy, Sharon A. Simpson, Rod S. Taylor, Sally J. Singh, Frances S. Mair, Bhautesh D. Jani on behalf of the PERFORM research team, BMC Medicine January 8, 2025 10.1186/s12916-024-03811-3

Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions - PERFORM: protocol for a randomised feasibility trial, Sharon Anne Simpson, Rachael A Evans, Hannah Rosemary Gilbert , Amy Branson, Shaun Barber, Emma McIntosh, Zahira Ahmed, Sarah Gerard Dean , Patrick Joseph Doherty , Nikki Gardiner, Colin Greaves, Paulina Daw, Tracy Ibbotson, Bhautesh Jani, Kate Jolly , Frances Mair , Paula Ormandy, Susan Smith, Sally J Singh, Rod Taylor, BMJ Open, April 05, 2024 10.1136/bmjopen-2023-083255

Evidence for exercise-based interventions across 45 different long-term conditions: an overview of systematic reviews, Grace O. Dibben, Lucy Gardiner, Hannah M. L. Young, Valerie Wells, Rachael A. Evans, Zahira Ahmed, Shaun Barber, Sarah Dean, Patrick Doherty, Nikki Gardiner, Colin Greaves, Tracy Ibbotson, Bhautesh D. Jani, Kate Jolly, Frances S. Mair, Emma McIntosh, Paula Ormandy, Sharon A. Simpson, Sayem Ahmed, Stefanie J. Krauth, Lewis Steell, Sally J. Singh, Rod S. Taylor, on behalf of the PERFORM research team, eClinicalMedicine, April 30, 2024 10.1016/j.eclinm.2024.102599

Association of latent class analysis-derived multimorbidity clusters with adverse health outcomes in patients with multiple long-term conditions: comparative results across three UK cohorts, Stefanie J. Krauth, Lewis Steell, Sayem Ahmed, Emma McIntosh, Grace O. Dibben, Peter Hanlon, Jim Lewsey, Barbara I. Nicholl, David A. McAllister, Susan M. Smith, Rachael Evans, Zahira Ahmed, Sarah Dean, Colin Greaves, Shaun Barber, Patrick Doherty, Nikki Gardiner, Tracy Ibbotson, Kate Jolly, Paula Ormandy, Sharon A. Simpson, Rod S. Taylor, Sally J. Singh, Frances S. Mair and Bhautesh Dinesh Jani, on behalf of the PERFORM research team, eClinicalMedicine, June 28, 2024 10.1016/j.eclinm.2024.102703

Media interest

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