Dr Marius Roman

Marius has been an NIHR Clinical Lecturer in Cardiac Surgery at the University of Leicester since 2018 (ranked second in the 2021 REF for Clinical Medicine and Higher Specialist trainee in Cardiothoracic Surgery. He was awarded his Doctor of Medicine degree from University of Cambridge in November 2016.

His clinical research is focused on clinical trials in cardiovascular disease with focus on underserved populations and interventions targeting frailty.  His other research interest is the risk stratification of patients for organ injury following cardiac surgery, and is currently supported by the Van Geest Heart and Cardiovascular Diseases Research Fund.

Marius is an NIHR Associate PI across the portfolio of trials delivered by the Interdisciplinary Cardiothoracic Research Network (CIRN), including Target SSI.

Current Investigator roles include

Co-Chief Investigator for the UK arm of the ROMA trial (comparing single vs. multiple arterial grafts during CABG)

Co-Applicant and Co-Investigator in the TRICS IV trial (comparing restrictive vs. liberal transfusions in young cardiac surgery patients)

Principal Investigator in the VAL-CARD trial (investigating organ injury prevention following treatment with Sodium Valproate)

Principal Investigator in the Ob-CARD trial. 

Previous Investigator roles include

Investigator in cardiothoracic transplantation trials (INSPIRE, PROCEED-II and DEVELOP-UK)

Marius' clinical research is focused on clinical trials in cardiovascular disease with focus on underserved populations and interventions targeting frailty.  His other research interest is the risk stratification of patients for organ injury following cardiac surgery, and is currently supported by the Van Geest Heart and Cardiovascular Diseases Research Fund.

Key Publications

S Pathak, FY Lai, J Miksza, MC Petrie, M Roman, S Murray, et al. Surgical or Percutaneous Coronary Revascularisation For Heart Failure: An In-Silico Model Using Routinely Collected Health Data To Emulate A Clinical Trial.  European Heart Journal. 2022 https://doi.org/10.1093/eurheartj/ehac670 PMID: 36350978 IF: 35.86. Citations: 0. Altmetric score: TBD

AS Adebayo*, M Roman*, S Yusoff, et al. Gene And Metabolite Expression Dependence On Body Mass Index In Human Myocardium. Scientific Reports. 2022 Jan 26;12(1):1425. 12 (1): 1-13  https://doi:10.1101/2021.06.29.21259697  PMID: 35082386. IF: 4.99. Citations: 0. Altmetric score: 5

M Roman, R Abbasciano, S Pathak, et al. Patient Blood Management Interventions Do Not Demonstrate Important Clinical Benefits Or Cost-Effectiveness In People Undergoing Surgery: A Network Meta-Analysis. British Journal of Anaesthesia.2020 Jan;126(1):149-156  https://doi.org/10.1016/j.bja.2020.04.087 PMID: 32620259. IF: 9.1. Citations: 41. Altmetric score: 26  The first author of a manuscript that informed two guidelines.

Abbasciano RG, Lai FY, Roman MA, etal. Activation of the innate immune response and organ injury after cardiac surgery: a systematic review and meta-analysis of randomised trials and analysis of individual patient data from randomised and non-randomised studies. British J Anaesth. 2021 Sep;127(3):365-375  doi: 10.1016/j.bja.2021.04.032. Epub 2021 Jul 3.  PMID: 34229833. IF: 9.1. Citations: 2. Altmetric score: 4.

M Roman, A Monaghan, GF Serraino, et al. Meta-Analysis Of The Influence Of Lifestyle Changes For Preoperative Weight Loss on Surgical Outcomes. British Journal of Surgery. 2019.106(3): 181-189. https://doi.org/10.1002/bjs.11001 PMID: 30328098. IF: 6.9. Citations: 22. Altmetric score: 136. The first author of a highly publicised manuscript in news outlets.

For media enquires please contact mr345@le.ac.uk 

Public and Patient Engagement

Marius was a Steering Committee member for the James Lind Alliance Priority Setting Partnership in Adult Heart Surgery which identified the top 10 national research priorities. He participated in the multi-stakeholder National Clinical Trials Initiative in Cardiac Surgery.

Outputs and Committees

Outputs include over 35 peer reviewed publications, including one paper cited over 600 times.  One study was disseminated by 13 international news outlets, and achieved a high altmetric score of 136, (which is in the top 5% of all altmetric outputs).  He was awarded the annual British Journal of Surgery award for most cited paper.

Marius is a peer reviewer for over 10 journals with impact factors ranging from 3 to 10.  He is enrolled in the NIHR review development scheme (NETS) and is the lead for Cardiothoracic Surgery academic trainees in the SCTS.  This role includes drafting a revised academic curriculum for training and accreditation in Cardiothoracic Surgery and setting up the Cardiac Surgery mentorship initiative.  He is a mentee in the NIHR academic mentorship programme (Professor Ian Chetter), and previously with the Academy of Medical Sciences mentoring programme (Professor Nicholas Morrell).  Marius is also an academic trainee member of the NIHR Mentorship Steering Group.

Marius organised 4 SCTS National Research Meetings (2017-2020) and a Grant writing workshop and is convenor for the MRes programme embedded in the 4-year BHF PhD programme at the University of Leicester.

Collaborations

Marius is collaborating with the Heart Surgery Priority Setting Partnership CSG1 working group and the National Cardiac Surgery PPI Group which supports his current research proposals and works with the Leicester Centre for Ethnic Health Research to improve research participation of underserved populations.

He collaborates with colleagues who have similar research interests in cardiovascular frailty and acute coronary syndrome, specifically with; 

Professor Iain Squire/Dr Shirley Sze, University of Leicester Heart Failure research team
Professor Vijay Kunadian, Newcastle University 
Professor Simon Conroy, University College London
Professor Katrina Poppe/Professor Rob Doughty, University of Auckland   

Marius also collaborates with Professor Fang Gao (Institute of Inflammation and Ageing, Birmingham) on Inflammageing in cardiovascular disease.

He works closely with Professor Lisa Kidd (University of Glasgow) on qualitative research methodology to improve research participation and with Professor Jules Griffin (Rowett Institute, Aberdeen) on metabolic markers of frailty and cardiovascular disease.

Marius is supported by the Leicester Clinical Trials Unit in his current research proposals.

Marius was awarded the Annual British Journal of Surgery Award for most cited paper