People

Dr David Guttery

Lecturer in Cancer Early Detection

Department: Genetics and Genome Biology, Department of

Telephone: +44 (0)116 252 3181

Email: dsg6@leicester.ac.uk

Address: Leicester Cancer Research Centre, College of Life Sciences, University of Leicester, Room 425, Level 4, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, PO BOX 65, Leicester LE2 7LX, United Kingdom

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Profile

I am the Lecturer in Cancer Early Detection in the Leicester Cancer Research Centre (LCRC), whose research focuses on translational studies using artificial intelligence and liquid biopsy for the detection and monitoring of cancer. I am also the Postgraduate Tutor for the LCRC and responsible for recruiting, development and well-being of all PhD students who are trained in the department.

My research also focuses on the cell biology of the malaria parasite Plasmodium, particularly during the mosquito stages of its life-cycle and how reversible protein phosphorylation plays a key role during these stages.

Research

My research is focused on the utility of circulating tumour DNA, combined with artificial intelligence (AI) towards earlier detection and monitoring of cancer. Over the past ten years, I have focused on earlier detection of acquired resistance to hormone therapies in metastatic breast cancer (as part of Professor Jacqui Shaw's CRUK-funded Programme). This has now expanded into using ctDNA for monitoring endometrial cancer relapse, as part of a wider gynaecological research group lead by Dr Esther Moss. I have recently developed a collaboration with Dr Harriet Walter and Dr Oladejo Olaleye, looking at improving PET/CT accuracy post-treatment, and predicting relapse through combination with ctDNA analysis and AI. I also have an exciting collaboration ongoing with Professor Yudong Zhang (School of Informatics) that looks to improve medical imaging methods for breast and other cancers using machine-learning. 

I am also focused on development of the malaria parasite, Plasmodium in the mosquito midgut, unravelling the cell biology and molecular mechanisms regulating cell division and reversible protein phosphorylation with a view to developing new therapeutics to combat the disease, in collaboration with Professor Rita Tewari (University of Nottingham).

Publications

Publications

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1.            Yu, X.; Wang, S.H.; Gorriz, J.M.; Jiang, X.W.; Guttery, D.S.; Zhang, Y.D. Pemnet for pectoral muscle segmentation. Biology (Basel) 2022, 11.

2.            Trethewey, C.S.; Walter, H.S.; Alqahtani, A.N.M.; Schmid, R.; Guttery, D.S.; Griffin, Y.; Ahearne, M.J.; Saldanha, G.S.; Jayne, S.P.N.; Dyer, M.J.S. Limitations of monitoring disease progression using circulating tumor DNA in lymphoma: An example from primary cutaneous dlbcl leg-type. Hemasphere 2022, 6, e690.

3.            Zhang, Y.D.; Satapathy, S.C.; Wu, D.; Guttery, D.S.; Gorriz, J.M.; Wang, S.H. Improving ductal carcinoma in situ classification by convolutional neural network with exponential linear unit and rank-based weighted pooling. Complex Intell Systems 2021, 7, 1295-1310.

4.            Zeeshan, M.; Pandey, R.; Subudhi, A.K.; Ferguson, D.J.P.; Kaur, G.; Rashpa, R.; Nugmanova, R.; Brady, D.; Bottrill, A.R.; Vaughan, S., et al. Protein phosphatase 1 regulates atypical mitotic and meiotic division in plasmodium sexual stages. Commun Biol 2021, 4, 760.

5.            Yu, X.; Kang, C.; Guttery, D.S.; Kadry, S.; Chen, Y.; Zhang, Y.D. Resnet-scda-50 for breast abnormality classification. IEEE/ACM Trans Comput Biol Bioinform 2021, 18, 94-102.

6.            Xia, S.J.; Gao, B.Z.; Wang, S.H.; Guttery, D.S.; Li, C.D.; Zhang, Y.D. Modeling of diagnosis for metabolic syndrome by integrating symptoms into physiochemical indexes. Biomed Pharmacother 2021, 137, 111367.

7.            Wang, S.H.; Nayak, D.R.; Guttery, D.S.; Zhang, X.; Zhang, Y.D. Covid-19 classification by ccshnet with deep fusion using transfer learning and discriminant correlation analysis. Inf Fusion 2021, 68, 131-148.

8.            Relton, A.; Collins, A.; Guttery, D.S.; Gorsia, D.N.; McDermott, H.J.; Moss, E.L. Patient acceptability of circulating tumour DNA testing in endometrial cancer follow-up. Eur J Cancer Care (Engl) 2021, e13429.

9.            Page, K.; Martinson, L.J.; Hastings, R.K.; Fernandez-Garcia, D.; Gleason, K.L.T.; Gray, M.C.; Rushton, A.J.; Goddard, K.; Guttery, D.S.; Stebbing, J., et al. Prevalence of ctdna in early screen-detected breast cancers using highly sensitive and specific dual molecular barcoded personalised mutation assays. Ann Oncol 2021.

10.          Page, K.; Martinson, L.J.; Fernandez-Garcia, D.; Hills, A.; Gleason, K.L.T.; Gray, M.C.; Rushton, A.J.; Nteliopoulos, G.; Hastings, R.K.; Goddard, K., et al. Circulating tumor DNA profiling from breast cancer screening through to metastatic disease. JCO Precis Oncol 2021, 5.

11.          Liu, S.; Zhao, L.; Wang, X.; Xin, Q.; Zhao, J.; Guttery, D.S.; Zhang, Y.D. Deep spatio-temporal representation and ensemble classification for attention deficit/hyperactivity disorder. IEEE Trans Neural Syst Rehabil Eng 2021, 29, 1-10.

12.          Kang, C.; Yu, X.; Wang, S.H.; Guttery, D.S.; Pandey, H.M.; Tian, Y.; Zhang, Y.D. A heuristic neural network structure relying on fuzzy logic for images scoring. IEEE Trans Fuzzy Syst 2021, 29, 34-45.

13.          Hastings, R.K.; Openshaw, M.R.; Vazquez, M.; Moreno-Cardenas, A.B.; Fernandez-Garcia, D.; Martinson, L.; Kulbicki, K.; Primrose, L.; Guttery, D.S.; Page, K., et al. Longitudinal whole-exome sequencing of cell-free DNA for tracking the co-evolutionary tumor and immune evasion dynamics: Longitudinal data from a single patient. Ann Oncol 2021, 32, 681-684.

14.          Zeeshan, M.; Pandey, R.; Ferguson, D.J.P.; Tromer, E.C.; Markus, R.; Abel, S.; Brady, D.; Daniel, E.; Limenitakis, R.; Bottrill, A.R., et al. Real-time dynamics of plasmodium ndc80 reveals unusual modes of chromosome segregation during parasite proliferation. J Cell Sci 2020, 134.

15.          Polymeros, K.; Guttery, D.S.; Hew, R.; Bishop, R.; Stannard, E.; Macip, S.; Symonds, P.; Moss, E.L. Differences in the molecular profile of endometrial cancers from british white and british south asian women. PLoS One 2020, 15, e0233900.

16.          Openshaw, M.R.; Mohamed, A.A.; Ottolini, B.; Fernandez-Garcia, D.; Richards, C.J.; Page, K.; Guttery, D.S.; Thomas, A.L.; Shaw, J.A. Longitudinal monitoring of circulating tumour DNA improves prognostication and relapse detection in gastroesophageal adenocarcinoma. Br J Cancer 2020, 123, 1271-1279.

17.          Moss, E.L.; Gorsia, D.N.; Collins, A.; Sandhu, P.; Foreman, N.; Gore, A.; Wood, J.; Kent, C.; Silcock, L.; Guttery, D.S. Utility of circulating tumor DNA for detection and monitoring of endometrial cancer recurrence and progression. Cancers (Basel) 2020, 12.

18.          Guttery, D.S.; Ramaprasad, A.; Ferguson, D.J.P.; Zeeshan, M.; Pandey, R.; Brady, D.; Holder, A.A.; Pain, A.; Tewari, R. Mre11 is crucial for malaria parasite transmission and its absence affects expression of interconnected networks of key genes essential for life. Cells 2020, 9.

19.          Guttery, D.S.; Pandey, R.; Ferguson, D.J.; Wall, R.J.; Brady, D.; Gupta, D.; Holder, A.A.; Tewari, R. Plasmodium deh is er-localized and crucial for oocyst mitotic division during malaria transmission. Life Sci Alliance 2020, 3.

20.          Wang, S.H.; Xie, S.; Chen, X.; Guttery, D.S.; Tang, C.; Sun, J.; Zhang, Y.D. Alcoholism identification based on an alexnet transfer learning model. Front Psychiatry 2019, 10, 205.

21.          Roques, M.; Stanway, R.R.; Rea, E.I.; Markus, R.; Brady, D.; Holder, A.A.; Guttery, D.S.; Tewari, R. Plasmodium centrin pbcen-4 localizes to the putative mtoc and is dispensable for malaria parasite proliferation. Biol Open 2019, 8.

22.          Page, K.; Shaw, J.A.; Guttery, D.S. The liquid biopsy: Towards standardisation in preparation for prime time. Lancet Oncol 2019, 20, 758-760.

23.          Moore, D.A.; Sereno, M.; Das, M.; Baena Acevedo, J.D.; Sinnadurai, S.; Smith, C.; McSweeney, A.; Su, X.; Officer, L.; Jones, C., et al. In situ growth in early lung adenocarcinoma may represent precursor growth or invasive clone outgrowth-a clinically relevant distinction. Mod Pathol 2019, 32, 1095-1105.

24.          Fernandez-Garcia, D.; Hills, A.; Page, K.; Hastings, R.K.; Toghill, B.; Goddard, K.S.; Ion, C.; Ogle, O.; Boydell, A.R.; Gleason, K., et al. Plasma cell-free DNA (cfdna) as a predictive and prognostic marker in patients with metastatic breast cancer. Breast Cancer Res 2019, 21, 149.

25.          Coombes, R.C.; Page, K.; Salari, R.; Hastings, R.K.; Armstrong, A.; Ahmed, S.; Ali, S.; Cleator, S.; Kenny, L.; Stebbing, J., et al. Personalized detection of circulating tumor DNA antedates breast cancer metastatic recurrence. Clin Cancer Res 2019, 25, 4255-4263.

26.          Wall, R.J.; Ferguson, D.J.P.; Freville, A.; Franke-Fayard, B.; Brady, D.; Zeeshan, M.; Bottrill, A.R.; Wheatley, S.; Fry, A.M.; Janse, C.J., et al. Plasmodium apc3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis. Sci Rep 2018, 8, 5610.

27.          Wall, R.J.; Ferguson, D.J.P.; Freville, A.; Franke-Fayard, B.; Brady, D.; Zeeshan, M.; Bottrill, A.R.; Wheatley, S.; Fry, A.M.; Janse, C.J., et al. Author correction: Plasmodium apc3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis. Sci Rep 2018, 8, 12814.

28.          Myint, N.N.M.; Verma, A.M.; Fernandez-Garcia, D.; Sarmah, P.; Tarpey, P.S.; Al-Aqbi, S.S.; Cai, H.; Trigg, R.; West, K.; Howells, L.M., et al. Circulating tumor DNA in patients with colorectal adenomas: Assessment of detectability and genetic heterogeneity. Cell Death Dis 2018, 9, 894.

29.          Guttery, D.S.; Hancox, R.A.; Mulligan, K.T.; Hughes, S.; Lambe, S.M.; Howard Pringle, J.; Walker, R.A.; Louise Jones, J.; Shaw, J.A. Correction to: Association of invasion-promoting tenascin-c additional domains with breast cancers in young women. Breast Cancer Res 2018, 20, 80.

30.          Guttery, D.S.; Blighe, K.; Polymeros, K.; Symonds, R.P.; Macip, S.; Moss, E.L. Racial differences in endometrial cancer molecular portraits in the cancer genome atlas. Oncotarget 2018, 9, 17093-17103.

31.          Shaw, J.A.; Guttery, D.S.; Hills, A.; Fernandez-Garcia, D.; Page, K.; Rosales, B.M.; Goddard, K.S.; Hastings, R.K.; Luo, J.; Ogle, O., et al. Mutation analysis of cell-free DNA and single circulating tumor cells in metastatic breast cancer patients with high circulating tumor cell counts. Clin Cancer Res 2017, 23, 88-96.

32.          Saini, E.; Zeeshan, M.; Brady, D.; Pandey, R.; Kaiser, G.; Koreny, L.; Kumar, P.; Thakur, V.; Tatiya, S.; Katris, N.J., et al. Photosensitized ina-labelled protein 1 (phil1) is novel component of the inner membrane complex and is required for plasmodium parasite development. Sci Rep 2017, 7, 15577.

33.          Page, K.; Guttery, D.S.; Fernandez-Garcia, D.; Hills, A.; Hastings, R.K.; Luo, J.; Goddard, K.; Shahin, V.; Woodley-Barker, L.; Rosales, B.M., et al. Next generation sequencing of circulating cell-free DNA for evaluating mutations and gene amplification in metastatic breast cancer. Clin Chem 2017, 63, 532-541.

34.          Openshaw, M.R.; Richards, C.J.; Guttery, D.S.; Shaw, J.A.; Thomas, A.L. The genetics of gastroesophageal adenocarcinoma and the use of circulating cell free DNA for disease detection and monitoring. Expert Rev Mol Diagn 2017, 17, 459-470.

35.          Openshaw, M.R.; Page, K.; Fernandez-Garcia, D.; Guttery, D.; Shaw, J.A. The role of ctdna detection and the potential of the liquid biopsy for breast cancer monitoring. Expert Rev Mol Diagn 2016, 16, 751-755.

36.          Roques, M.; Wall, R.J.; Douglass, A.P.; Ramaprasad, A.; Ferguson, D.J.; Kaindama, M.L.; Brusini, L.; Joshi, N.; Rchiad, Z.; Brady, D., et al. Plasmodium p-type cyclin cyc3 modulates endomitotic growth during oocyst development in mosquitoes. PLoS Pathog 2015, 11, e1005273.

37.          Magnani, L.; Patten, D.K.; Nguyen, V.T.; Hong, S.P.; Steel, J.H.; Patel, N.; Lombardo, Y.; Faronato, M.; Gomes, A.R.; Woodley, L., et al. The pioneer factor pbx1 is a novel driver of metastatic progression in eralpha-positive breast cancer. Oncotarget 2015, 6, 21878-21891.

38.          Guttery, D.S.; Roques, M.; Holder, A.A.; Tewari, R. Commit and transmit: Molecular players in plasmodium sexual development and zygote differentiation. Trends Parasitol 2015, 31, 676-685.

39.          Guttery, D.S.; Page, K.; Hills, A.; Woodley, L.; Marchese, S.D.; Rghebi, B.; Hastings, R.K.; Luo, J.; Pringle, J.H.; Stebbing, J., et al. Noninvasive detection of activating estrogen receptor 1 (esr1) mutations in estrogen receptor-positive metastatic breast cancer. Clin Chem 2015, 61, 974-982.

40.          Palmieri, C.; Cleator, S.; Kilburn, L.S.; Kim, S.B.; Ahn, S.H.; Beresford, M.; Gong, G.; Mansi, J.; Mallon, E.; Reed, S., et al. Neocent: A randomised feasibility and translational study comparing neoadjuvant endocrine therapy with chemotherapy in er-rich postmenopausal primary breast cancer. Breast Cancer Res Treat 2014, 148, 581-590.

41.          Guttery, D.S.; Poulin, B.; Ramaprasad, A.; Wall, R.J.; Ferguson, D.J.; Brady, D.; Patzewitz, E.M.; Whipple, S.; Straschil, U.; Wright, M.H., et al. Genome-wide functional analysis of plasmodium protein phosphatases reveals key regulators of parasite development and differentiation. Cell Host Microbe 2014, 16, 128-140.

42.          Blighe, K.; Kenny, L.; Patel, N.; Guttery, D.S.; Page, K.; Gronau, J.H.; Golshani, C.; Stebbing, J.; Coombes, R.C.; Shaw, J.A. Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes. PLoS One 2014, 9, e115346.

43.          Poulin, B.; Patzewitz, E.M.; Brady, D.; Silvie, O.; Wright, M.H.; Ferguson, D.J.; Wall, R.J.; Whipple, S.; Guttery, D.S.; Tate, E.W., et al. Unique apicomplexan imc sub-compartment proteins are early markers for apical polarity in the malaria parasite. Biol Open 2013, 2, 1160-1170.

44.          Patzewitz, E.M.; Guttery, D.S.; Poulin, B.; Ramakrishnan, C.; Ferguson, D.J.; Wall, R.J.; Brady, D.; Holder, A.A.; Szoor, B.; Tewari, R. An ancient protein phosphatase, shlp1, is critical to microneme development in plasmodium ookinetes and parasite transmission. Cell Rep 2013, 3, 622-629.

45.          Page, K.; Guttery, D.S.; Zahra, N.; Primrose, L.; Elshaw, S.R.; Pringle, J.H.; Blighe, K.; Marchese, S.D.; Hills, A.; Woodley, L., et al. Influence of plasma processing on recovery and analysis of circulating nucleic acids. PLoS One 2013, 8, e77963.

46.          Guttery, D.S.; Pittman, J.K.; Frenal, K.; Poulin, B.; McFarlane, L.R.; Slavic, K.; Wheatley, S.P.; Soldati-Favre, D.; Krishna, S.; Tewari, R., et al. The plasmodium berghei ca(2+)/h(+) exchanger, pbcax, is essential for tolerance to environmental ca(2+) during sexual development. PLoS Pathog 2013, 9, e1003191.

47.          Guttery, D.S.; Blighe, K.; Page, K.; Marchese, S.D.; Hills, A.; Coombes, R.C.; Stebbing, J.; Shaw, J.A. Hide and seek: Tell-tale signs of breast cancer lurking in the blood. Cancer Metastasis Rev 2013, 32, 289-302.

48.          Shaw, J.A.; Page, K.; Blighe, K.; Hava, N.; Guttery, D.; Ward, B.; Brown, J.; Ruangpratheep, C.; Stebbing, J.; Payne, R., et al. Genomic analysis of circulating cell-free DNA infers breast cancer dormancy. Genome Res 2012, 22, 220-231.

49.          Payne, R.E.; Hava, N.L.; Page, K.; Blighe, K.; Ward, B.; Slade, M.; Brown, J.; Guttery, D.S.; Zaidi, S.A.; Stebbing, J., et al. The presence of disseminated tumour cells in the bone marrow is inversely related to circulating free DNA in plasma in breast cancer dormancy. Br J Cancer 2012, 106, 375-382.

50.          Guttery, D.S.; Poulin, B.; Ferguson, D.J.; Szoor, B.; Wickstead, B.; Carroll, P.L.; Ramakrishnan, C.; Brady, D.; Patzewitz, E.M.; Straschil, U., et al. A unique protein phosphatase with kelch-like domains (ppkl) in plasmodium modulates ookinete differentiation, motility and invasion. PLoS Pathog 2012, 8, e1002948.

51.          Guttery, D.S.; Holder, A.A.; Tewari, R. Sexual development in plasmodium: Lessons from functional analyses. PLoS Pathog 2012, 8, e1002404.

52.          Guttery, D.S.; Ferguson, D.J.; Poulin, B.; Xu, Z.; Straschil, U.; Klop, O.; Solyakov, L.; Sandrini, S.M.; Brady, D.; Nieduszynski, C.A., et al. A putative homologue of cdc20/cdh1 in the malaria parasite is essential for male gamete development. PLoS Pathog 2012, 8, e1002554.

53.          Page, K.; Hava, N.; Ward, B.; Brown, J.; Guttery, D.S.; Ruangpratheep, C.; Blighe, K.; Sharma, A.; Walker, R.A.; Coombes, R.C., et al. Detection of her2 amplification in circulating free DNA in patients with breast cancer. Br J Cancer 2011, 104, 1342-1348.

54.          Guttery, D.S.; Shaw, J.A.; Lloyd, K.; Pringle, J.H.; Walker, R.A. Expression of tenascin-c and its isoforms in the breast. Cancer Metastasis Rev 2010, 29, 595-606.

55.          Guttery, D.S.; Hancox, R.A.; Mulligan, K.T.; Hughes, S.; Lambe, S.M.; Pringle, J.H.; Walker, R.A.; Jones, J.L.; Shaw, J.A. Association of invasion-promoting tenascin-c additional domains with breast cancers in young women. Breast Cancer Res 2010, 12, R57.

56.          Russell, L.J.; Capasso, M.; Vater, I.; Akasaka, T.; Bernard, O.A.; Calasanz, M.J.; Chandrasekaran, T.; Chapiro, E.; Gesk, S.; Griffiths, M., et al. Deregulated expression of cytokine receptor gene, crlf2, is involved in lymphoid transformation in b-cell precursor acute lymphoblastic leukemia. Blood 2009, 114, 2688-2698.

57.          Hancox, R.A.; Allen, M.D.; Holliday, D.L.; Edwards, D.R.; Pennington, C.J.; Guttery, D.S.; Shaw, J.A.; Walker, R.A.; Pringle, J.H.; Jones, J.L. Tumour-associated tenascin-c isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms. Breast Cancer Res 2009, 11, R24.

 

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Supervision

I currently supervise PhD projects looking at the utility of ctDNA for earlier detection and monitoring of cancer as well as joint projects with colleagues in the School of Informatics in improving diagnostic imaging using artificial intelligence.

Teaching

MSc Cancer Molecular Pathology and Therapeutics - Co-Course Convenor
BS3031 - Human Genetics
BS3003 - Cancer Cell and Molecular Biology
MB1080 - Introduction to Medical Sciences

Press and media

Blood tests for cancer; artificial intelligence in earlier diagnosis; malaria

Activities

Steering Committee Member - ECMC Junior Investigator Networking Group (JING)
Higher Education Academy - Fellow
Member - European Network for Individualised Treatment in Endometrial Cancer (ENITEC)
Associate Editor - Oncogene
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