Dr David Guttery

Dr David Guttery received a BSc (Hons) in Medicinal Biochemistry from the University of Wolverhampton in 2003, developing an interest in cancer biology and subsequently undertaking an MSc in Molecular Pathology and Toxicology at the University of Leicester in 2004. This was followed by a PhD at The University of Leicester under the supervision of Professor Jacqui Shaw to understand the role of the extracellular matrix protein tenascin-C in breast cancer development, graduating in 2009.

As a postdoctoral Research Associate, Dr Guttery worked in the group of Professor Jacqui Shaw at the University of Leicester to determine the utility of the liquid biopsy for early detection and monitoring of breast cancer, showing that mutations in oestrogen receptor could be detected in the blood and determine resistance to hormonal therapies. He also spent two years as a Research Fellow in the laboratory of Professor Rita Tewari, deciphering of function and localisation of the protein phosphatases during sexual development of the malaria parasite. His current work delves deeper into the regulatory mechanisms of protein phosphatases in malaria parasite sexual development and expanding the applications of liquid biopsy technologies in oncology, with integration of artificial intelligence.

Dr Guttery was appointed as a Lecturer at the University of Leicester in 2017 and was promoted to Associate Professor in 2024. He is also the College of Life Sciences Deputy Director of Postgraduate Research. 

Unraveling the Mysteries of Malaria Parasite Sexual Development

My primary research interest lies in understanding the role of protein phosphatases in the sexual development of the malaria parasite. Malaria remains a major global health challenge, and its life cycle complexity demands multifaceted research approaches. My research investigates how protein phosphatases regulate the parasite's development in the mosquito, aiming to identify potential targets for novel therapeutic interventions. This employs a combination of microscopy, reverse genetics, proteomics, and ultrastructure techniques. Microscopy allows visualisation of the parasite's development stages in real-time, providing critical insights into morphological changes. Reverse genetics enables manipulation of specific genes encoding protein phosphatases (and other genes), revealing their functional roles. Proteomics helps in identifying and quantifying proteins involved in these processes, while ultrastructure techniques offer detailed views of cellular and subcellular architectures. This integrative approach is crucial for developing a comprehensive understanding of the parasite's biology and identifying vulnerabilities that can be exploited to combat malaria.

Innovations in Cancer Detection and Monitoring

In parallel, I am deeply invested in advancing the field of oncology through the development and refinement of liquid biopsy techniques for early cancer detection and monitoring. Liquid biopsy, a minimally invasive method, offers a promising alternative to traditional tissue biopsies, enabling real-time monitoring of tumour dynamics and therapeutic responses.

My work in this area leverages state-of-the-art techniques, including next-generation sequencing (NGS), quantitative PCR (qPCR), droplet digital PCR (ddPCR), and multi-omic analysis. NGS allows for comprehensive genomic profiling, detecting mutations, and alterations that drive cancer progression. qPCR and ddPCR provide precise quantification of specific genetic changes, essential for tracking minimal residual disease and assessing treatment efficacy. Multi-omic analysis integrates genomic, transcriptomic, proteomic, and metabolomic data, offering a holistic view of the tumour environment and identifying biomarkers for early detection and personalised treatment strategies.

Bridging Parasitology and Oncology

While my research focuses on two distinct fields, there is a unifying theme in the pursuit of understanding complex biological systems and translating these insights into practical applications for improving human health. The technical skills and analytical approaches in parasitology research are directly applicable to my work in oncology, and vice versa. This cross-disciplinary expertise allows the approaching of scientific problems with a unique perspective, fostering innovation and collaboration.

1.            Yu, X. and Ren, Z. and Guttery, D.S. and Zhang, Y.D. (2024) DF-dRVFL: A novel deep feature based classifier for breast mass classification. Multimed Tools Appl 83, 14393-14422. 10.1007/s11042-023-15864-2

2.            Shaw, J.A.,  Page, K.,  Wren, E.,  de Bruin, E.C.,  Kalashnikova, E.,  Hastings, R. et al. (2024) Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer. JCO Precis Oncol 8, e2300456. 10.1200/PO.23.00456

3.            Guttery, D.S. and Zeeshan, M. and Holder, A.A. and Tewari, R. (2024) The molecular mechanisms driving Plasmodium cell division. Biochem Soc Trans 52, 593-602. 10.1042/BST20230403

4.            Darif, N.D.,  Ganter, M.,  Dziekan, J.M.,  Kilian, N.,  Brancucci, N.,  Ng, C. et al. (2024) BioMalPar XX: looking back on, and forward from, 20 years of malaria research. Trends Parasitol. 10.1016/j.pt.2024.06.012

5.            Zeeshan, M.,  Rea, E.,  Abel, S.,  Vukusic, K.,  Markus, R.,  Brady, D. et al. (2023) Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages. Nat Commun 14, 5652. 10.1038/s41467-023-41395-3

6.            Stebbing, J.,  Takis, P.G.,  Sands, C.J.,  Maslen, L.,  Lewis, M.R.,  Gleason, K. et al. (2023) Comparison of phenomics and cfDNA in a large breast screening population: the Breast Screening and Monitoring Study (BSMS). Oncogene 42, 825-832. 10.1038/s41388-023-02591-z

7.            Guttery, D.S. and Zeeshan, M. and Holder, A.A. and Tromer, E.C. and Tewari, R. (2023) Meiosis in Plasmodium: how does it work? Trends Parasitol 39, 812-821. 10.1016/j.pt.2023.07.002

8.            Yu, X. and Wang, S.H. and Gorriz, J.M. and Jiang, X.W. and Guttery, D.S. and Zhang, Y.D. (2022) PeMNet for Pectoral Muscle Segmentation. Biology (Basel) 11. 10.3390/biology11010134

9.            Trethewey, C.S.,  Walter, H.S.,  Alqahtani, A.N.M.,  Schmid, R.,  Guttery, D.S.,  Griffin, Y. et al. (2022) Limitations of Monitoring Disease Progression Using Circulating Tumor DNA in Lymphoma: An Example From Primary Cutaneous DLBCL Leg-type. Hemasphere 6, e690. 10.1097/HS9.0000000000000690

10.          Harrod, A.,  Lai, C.F.,  Goldsbrough, I.,  Simmons, G.M.,  Oppermans, N.,  Santos, D.B. et al. (2022) Genome engineering for estrogen receptor mutations reveals differential responses to anti-estrogens and new prognostic gene signatures for breast cancer. Oncogene 41, 4905-4915. 10.1038/s41388-022-02483-8

11.          Guttery, D.S. and Zeeshan, M. and Ferguson, D.J.P. and Holder, A.A. and Tewari, R. (2022) Division and Transmission: Malaria Parasite Development in the Mosquito. Annu Rev Microbiol 76, 113-134. 10.1146/annurev-micro-041320-010046

12.          Fernandez-Garcia, D.,  Nteliopoulos, G.,  Hastings, R.K.,  Rushton, A.,  Page, K.,  Allsopp, R.C. et al. (2022) Shallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer. Br J Cancer 127, 1858-1864. 10.1038/s41416-022-01962-9

13.          Zhang, Y.D. and Satapathy, S.C. and Wu, D. and Guttery, D.S. and Gorriz, J.M. and Wang, S.H. (2021) Improving ductal carcinoma in situ classification by convolutional neural network with exponential linear unit and rank-based weighted pooling. Complex Intell Systems 7, 1295-1310. 10.1007/s40747-020-00218-4

14.          Zeeshan, M.,  Pandey, R.,  Subudhi, A.K.,  Ferguson, D.J.P.,  Kaur, G.,  Rashpa, R. et al. (2021) Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages. Commun Biol 4, 760. 10.1038/s42003-021-02273-0

15.          Yu, X. and Kang, C. and Guttery, D.S. and Kadry, S. and Chen, Y. and Zhang, Y.D. (2021) ResNet-SCDA-50 for Breast Abnormality Classification. IEEE/ACM Trans Comput Biol Bioinform 18, 94-102. 10.1109/TCBB.2020.2986544

16.          Xia, S.J. and Gao, B.Z. and Wang, S.H. and Guttery, D.S. and Li, C.D. and Zhang, Y.D. (2021) Modeling of diagnosis for metabolic syndrome by integrating symptoms into physiochemical indexes. Biomed Pharmacother 137, 111367. 10.1016/j.biopha.2021.111367

17.          Wang, S.H. and Nayak, D.R. and Guttery, D.S. and Zhang, X. and Zhang, Y.D. (2021) COVID-19 classification by CCSHNet with deep fusion using transfer learning and discriminant correlation analysis. Inf Fusion 68, 131-148. 10.1016/j.inffus.2020.11.005

18.          Relton, A. and Collins, A. and Guttery, D.S. and Gorsia, D.N. and McDermott, H.J. and Moss, E.L. (2021) Patient acceptability of circulating tumour DNA testing in endometrial cancer follow-up. Eur J Cancer Care (Engl) 30, e13429. 10.1111/ecc.13429

19.          Page, K.,  Martinson, L.J.,  Hastings, R.K.,  Fernandez-Garcia, D.,  Gleason, K.L.T.,  Gray, M.C. et al. (2021) Prevalence of ctDNA in early screen-detected breast cancers using highly sensitive and specific dual molecular barcoded personalised mutation assays. Ann Oncol 32, 1057-1060. 10.1016/j.annonc.2021.04.018

20.          Page, K.,  Martinson, L.J.,  Fernandez-Garcia, D.,  Hills, A.,  Gleason, K.L.T.,  Gray, M.C. et al. (2021) Circulating Tumor DNA Profiling From Breast Cancer Screening Through to Metastatic Disease. JCO Precis Oncol 5. 10.1200/PO.20.00522

21.          Nteliopoulos, G.,  Page, K.,  Hills, A.,  Howarth, K.,  Emmett, W.,  Green, E. et al. (2021) Comparison of two targeted ultra-deep sequencing technologies for analysis of plasma circulating tumour DNA in endocrine-therapy-resistant breast cancer patients. Breast Cancer Res Treat 188, 465-476. 10.1007/s10549-021-06220-9

22.          Liu, S.,  Zhao, L.,  Wang, X.,  Xin, Q.,  Zhao, J.,  Guttery, D.S. et al. (2021) Deep Spatio-Temporal Representation and Ensemble Classification for Attention Deficit/Hyperactivity Disorder. IEEE Trans Neural Syst Rehabil Eng 29, 1-10. 10.1109/TNSRE.2020.3019063

23.          Kang, C.,  Yu, X.,  Wang, S.H.,  Guttery, D.S.,  Pandey, H.M.,  Tian, Y. et al. (2021) A Heuristic Neural Network Structure Relying on Fuzzy Logic for Images Scoring. IEEE Trans Fuzzy Syst 29, 34-45. 10.1109/TFUZZ.2020.2966163

24.          Hastings, R.K.,  Openshaw, M.R.,  Vazquez, M.,  Moreno-Cardenas, A.B.,  Fernandez-Garcia, D.,  Martinson, L. et al. (2021) Longitudinal whole-exome sequencing of cell-free DNA for tracking the co-evolutionary tumor and immune evasion dynamics: longitudinal data from a single patient. Ann Oncol 32, 681-684. 10.1016/j.annonc.2021.02.007

25.          Collins, A. and Taylor, A. and Guttery, D.S. and Moss, E.L. (2021) Innovative Follow-up Strategies for Endometrial Cancer. Clin Oncol (R Coll Radiol) 33, e383-e392. 10.1016/j.clon.2021.06.001

26.          Zeeshan, M.,  Pandey, R.,  Ferguson, D.J.P.,  Tromer, E.C.,  Markus, R.,  Abel, S. et al. (2020) Real-time dynamics of Plasmodium NDC80 reveals unusual modes of chromosome segregation during parasite proliferation. J Cell Sci 134. 10.1242/jcs.245753

27.          Polymeros, K.,  Guttery, D.S.,  Hew, R.,  Bishop, R.,  Stannard, E.,  Macip, S. et al. (2020) Differences in the molecular profile of endometrial cancers from British White and British South Asian women. PLoS One 15, e0233900. 10.1371/journal.pone.0233900

28.          Openshaw, M.R.,  Suwaidan, A.A.,  Ottolini, B.,  Fernandez-Garcia, D.,  Richards, C.J.,  Page, K. et al. (2020) Longitudinal monitoring of circulating tumour DNA improves prognostication and relapse detection in gastroesophageal adenocarcinoma. Br J Cancer 123, 1271-1279. 10.1038/s41416-020-1002-8

29.          Moss, E.L.,  Gorsia, D.N.,  Collins, A.,  Sandhu, P.,  Foreman, N.,  Gore, A. et al. (2020) Utility of Circulating Tumor DNA for Detection and Monitoring of Endometrial Cancer Recurrence and Progression. Cancers (Basel) 12. 10.3390/cancers12082231

30.          Guttery, D.S.,  Ramaprasad, A.,  Ferguson, D.J.P.,  Zeeshan, M.,  Pandey, R.,  Brady, D. et al. (2020) MRE11 Is Crucial for Malaria Parasite Transmission and Its Absence Affects Expression of Interconnected Networks of Key Genes Essential for Life. Cells 9. 10.3390/cells9122590

31.          Guttery, D.S.,  Pandey, R.,  Ferguson, D.J.,  Wall, R.J.,  Brady, D.,  Gupta, D. et al. (2020) Plasmodium DEH is ER-localized and crucial for oocyst mitotic division during malaria transmission. Life Sci Alliance 3. 10.26508/lsa.202000879

32.          Wang, S.H.,  Xie, S.,  Chen, X.,  Guttery, D.S.,  Tang, C.,  Sun, J. et al. (2019) Alcoholism Identification Based on an AlexNet Transfer Learning Model. Front Psychiatry 10, 205. 10.3389/fpsyt.2019.00205

33.          Roques, M.,  Stanway, R.R.,  Rea, E.I.,  Markus, R.,  Brady, D.,  Holder, A.A. et al. (2019) Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation. Biol Open 8. 10.1242/bio.036822

34.          Page, K. and Shaw, J.A. and Guttery, D.S. (2019) The liquid biopsy: towards standardisation in preparation for prime time. Lancet Oncol 20, 758-760. 10.1016/S1470-2045(19)30310-9

35.          Moore, D.A.,  Sereno, M.,  Das, M.,  Baena Acevedo, J.D.,  Sinnadurai, S.,  Smith, C. et al. (2019) In situ growth in early lung adenocarcinoma may represent precursor growth or invasive clone outgrowth-a clinically relevant distinction. Mod Pathol 32, 1095-1105. 10.1038/s41379-019-0257-1

36.          Fernandez-Garcia, D.,  Hills, A.,  Page, K.,  Hastings, R.K.,  Toghill, B.,  Goddard, K.S. et al. (2019) Plasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer. Breast Cancer Res 21, 149. 10.1186/s13058-019-1235-8

37.          Coombes, R.C.,  Page, K.,  Salari, R.,  Hastings, R.K.,  Armstrong, A.,  Ahmed, S. et al. (2019) Personalized Detection of Circulating Tumor DNA Antedates Breast Cancer Metastatic Recurrence. Clin Cancer Res 25, 4255-4263. 10.1158/1078-0432.CCR-18-3663

38.          Wall, R.J.,  Ferguson, D.J.P.,  Freville, A.,  Franke-Fayard, B.,  Brady, D.,  Zeeshan, M. et al. (2018) Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis. Sci Rep 8, 5610. 10.1038/s41598-018-23871-9

39.          Wall, R.J.,  Ferguson, D.J.P.,  Freville, A.,  Franke-Fayard, B.,  Brady, D.,  Zeeshan, M. et al. (2018) Author Correction: Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis. Sci Rep 8, 12814. 10.1038/s41598-018-30924-6

40.          Myint, N.N.M.,  Verma, A.M.,  Fernandez-Garcia, D.,  Sarmah, P.,  Tarpey, P.S.,  Al-Aqbi, S.S. et al. (2018) Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity. Cell Death Dis 9, 894. 10.1038/s41419-018-0934-x

41.          Guttery, D.S.,  Hancox, R.A.,  Mulligan, K.T.,  Hughes, S.,  Lambe, S.M.,  Howard Pringle, J. et al. (2018) Correction to: Association of invasion-promoting tenascin-C additional domains with breast cancers in young women. Breast Cancer Res 20, 80. 10.1186/s13058-018-0997-8

42.          Guttery, D.S. and Blighe, K. and Polymeros, K. and Symonds, R.P. and Macip, S. and Moss, E.L. (2018) Racial differences in endometrial cancer molecular portraits in The Cancer Genome Atlas. Oncotarget 9, 17093-17103. 10.18632/oncotarget.24907

43.          Shaw, J.A.,  Guttery, D.S.,  Hills, A.,  Fernandez-Garcia, D.,  Page, K.,  Rosales, B.M. et al. (2017) Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts. Clin Cancer Res 23, 88-96. 10.1158/1078-0432.CCR-16-0825

44.          Saini, E.,  Zeeshan, M.,  Brady, D.,  Pandey, R.,  Kaiser, G.,  Koreny, L. et al. (2017) Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite development. Sci Rep 7, 15577. 10.1038/s41598-017-15781-z

45.          Page, K.,  Guttery, D.S.,  Fernandez-Garcia, D.,  Hills, A.,  Hastings, R.K.,  Luo, J. et al. (2017) Next Generation Sequencing of Circulating Cell-Free DNA for Evaluating Mutations and Gene Amplification in Metastatic Breast Cancer. Clin Chem 63, 532-541. 10.1373/clinchem.2016.261834

46.          Openshaw, M.R. and Richards, C.J. and Guttery, D.S. and Shaw, J.A. and Thomas, A.L. (2017) The genetics of gastroesophageal adenocarcinoma and the use of circulating cell free DNA for disease detection and monitoring. Expert Rev Mol Diagn 17, 459-470. 10.1080/14737159.2017.1308824

47.          Openshaw, M.R. and Page, K. and Fernandez-Garcia, D. and Guttery, D. and Shaw, J.A. (2016) The role of ctDNA detection and the potential of the liquid biopsy for breast cancer monitoring. Expert Rev Mol Diagn 16, 751-755. 10.1080/14737159.2016.1184974

48.          Roques, M.,  Wall, R.J.,  Douglass, A.P.,  Ramaprasad, A.,  Ferguson, D.J.,  Kaindama, M.L. et al. (2015) Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes. PLoS Pathog 11, e1005273. 10.1371/journal.ppat.1005273

49.          Magnani, L.,  Patten, D.K.,  Nguyen, V.T.,  Hong, S.P.,  Steel, J.H.,  Patel, N. et al. (2015) The pioneer factor PBX1 is a novel driver of metastatic progression in ERalpha-positive breast cancer. Oncotarget 6, 21878-21891. 10.18632/oncotarget.4243

50.          Guttery, D.S. and Roques, M. and Holder, A.A. and Tewari, R. (2015) Commit and Transmit: Molecular Players in Plasmodium Sexual Development and Zygote Differentiation. Trends Parasitol 31, 676-685. 10.1016/j.pt.2015.08.002

51.          Guttery, D.S.,  Page, K.,  Hills, A.,  Woodley, L.,  Marchese, S.D.,  Rghebi, B. et al. (2015) Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positive metastatic breast cancer. Clin Chem 61, 974-982. 10.1373/clinchem.2015.238717

52.          Palmieri, C.,  Cleator, S.,  Kilburn, L.S.,  Kim, S.B.,  Ahn, S.H.,  Beresford, M. et al. (2014) NEOCENT: a randomised feasibility and translational study comparing neoadjuvant endocrine therapy with chemotherapy in ER-rich postmenopausal primary breast cancer. Breast Cancer Res Treat 148, 581-590. 10.1007/s10549-014-3183-4

53.          Guttery, D.S.,  Poulin, B.,  Ramaprasad, A.,  Wall, R.J.,  Ferguson, D.J.,  Brady, D. et al. (2014) Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation. Cell Host Microbe 16, 128-140. 10.1016/j.chom.2014.05.020

54.          Blighe, K.,  Kenny, L.,  Patel, N.,  Guttery, D.S.,  Page, K.,  Gronau, J.H. et al. (2014) Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes. PLoS One 9, e115346. 10.1371/journal.pone.0115346

55.          Poulin, B.,  Patzewitz, E.M.,  Brady, D.,  Silvie, O.,  Wright, M.H.,  Ferguson, D.J. et al. (2013) Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite. Biol Open 2, 1160-1170. 10.1242/bio.20136163

56.          Patzewitz, E.M.,  Guttery, D.S.,  Poulin, B.,  Ramakrishnan, C.,  Ferguson, D.J.,  Wall, R.J. et al. (2013) An ancient protein phosphatase, SHLP1, is critical to microneme development in Plasmodium ookinetes and parasite transmission. Cell Rep 3, 622-629. 10.1016/j.celrep.2013.01.032

57.          Page, K.,  Guttery, D.S.,  Zahra, N.,  Primrose, L.,  Elshaw, S.R.,  Pringle, J.H. et al. (2013) Influence of plasma processing on recovery and analysis of circulating nucleic acids. PLoS One 8, e77963. 10.1371/journal.pone.0077963

58.          Guttery, D.S.,  Pittman, J.K.,  Frenal, K.,  Poulin, B.,  McFarlane, L.R.,  Slavic, K. et al. (2013) The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development. PLoS Pathog 9, e1003191. 10.1371/journal.ppat.1003191

59.          Guttery, D.S.,  Blighe, K.,  Page, K.,  Marchese, S.D.,  Hills, A.,  Coombes, R.C. et al. (2013) Hide and seek: tell-tale signs of breast cancer lurking in the blood. Cancer Metastasis Rev 32, 289-302. 10.1007/s10555-012-9414-4

60.          Shaw, J.A.,  Page, K.,  Blighe, K.,  Hava, N.,  Guttery, D.,  Ward, B. et al. (2012) Genomic analysis of circulating cell-free DNA infers breast cancer dormancy. Genome Res 22, 220-231. 10.1101/gr.123497.111

61.          Payne, R.E.,  Hava, N.L.,  Page, K.,  Blighe, K.,  Ward, B.,  Slade, M. et al. (2012) The presence of disseminated tumour cells in the bone marrow is inversely related to circulating free DNA in plasma in breast cancer dormancy. Br J Cancer 106, 375-382. 10.1038/bjc.2011.537

62.          Guttery, D.S.,  Poulin, B.,  Ferguson, D.J.,  Szoor, B.,  Wickstead, B.,  Carroll, P.L. et al. (2012) A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion. PLoS Pathog 8, e1002948. 10.1371/journal.ppat.1002948

63.          Guttery, D.S. and Holder, A.A. and Tewari, R. (2012) Sexual development in Plasmodium: lessons from functional analyses. PLoS Pathog 8, e1002404. 10.1371/journal.ppat.1002404

64.          Guttery, D.S.,  Ferguson, D.J.,  Poulin, B.,  Xu, Z.,  Straschil, U.,  Klop, O. et al. (2012) A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development. PLoS Pathog 8, e1002554. 10.1371/journal.ppat.1002554

65.          Page, K.,  Hava, N.,  Ward, B.,  Brown, J.,  Guttery, D.S.,  Ruangpratheep, C. et al. (2011) Detection of HER2 amplification in circulating free DNA in patients with breast cancer. Br J Cancer 104, 1342-1348. 10.1038/bjc.2011.89

66.          Guttery, D.S. and Shaw, J.A. and Lloyd, K. and Pringle, J.H. and Walker, R.A. (2010) Expression of tenascin-C and its isoforms in the breast. Cancer Metastasis Rev 29, 595-606. 10.1007/s10555-010-9249-9

67.          Guttery, D.S.,  Hancox, R.A.,  Mulligan, K.T.,  Hughes, S.,  Lambe, S.M.,  Pringle, J.H. et al. (2010) Association of invasion-promoting tenascin-C additional domains with breast cancers in young women. Breast Cancer Res 12, R57. 10.1186/bcr2618

68.          Russell, L.J.,  Capasso, M.,  Vater, I.,  Akasaka, T.,  Bernard, O.A.,  Calasanz, M.J. et al. (2009) Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. Blood 114, 2688-2698. 10.1182/blood-2009-03-208397

69.          Hancox, R.A.,  Allen, M.D.,  Holliday, D.L.,  Edwards, D.R.,  Pennington, C.J.,  Guttery, D.S. et al. (2009) Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms. Breast Cancer Res 11, R24. 10.1186/bcr2251

Dr Guttery currently supervises PhD projects looking at the utility of ctDNA for earlier detection and monitoring of cancer, as well as joint projects with colleagues in the School of Informatics in improving diagnostic imaging using artificial intelligence. He is also looking for applications from students to work on projects that aim to further understand the role of Plasmodium protein phosphatases during sexual development of the malaria parasite.

Dr Guttery is a course co-convenor for MSc Cancer Molecular Pathology and Therapeutics, and also teaches on the following modules:

• BS3031 - Human Genetics
• BS3003 - Cancer Cell and Molecular Biology
• BS3083 - Respiratory and Cancer Precision Medicine 
• MB1080 - Introduction to Medical Sciences
• ADBS001 - First year personal tutoring

• Blood tests for cancer
• Artificial intelligence in earlier diagnosis
• Malaria