People

Professor David Critchley

Emeritus Professor of Molecular Cell Biology

Department: Molecular Cell Biology, Department of

Telephone: +44 (0)7519 275 487

Email: drc@leicester.ac.uk

Profile

• PhD in Physiology: University of Bristol 1968.

• Instructor Dept. of Physiology Rutgers Medical School NJ USA 1968-1970.

• Imperial Cancer Research Fund London 1970-75.

• Lecturer Department of Biochemistry University of Leicester UK. 1975-1983

• Senior Lecturer Department of Biochemistry University of Leicester UK. 1983-1993

• Professor Department of Biochemistry University of Leicester UK. 1993-2012

• Head of Department 1994-2000

• Visiting Scientist NIH Bethesda Md USA 1980 1983 and 1990 Massachusetts Institute of Technology Cambridge Ma 1989

• External Roles

MRC Molecular and Cell Grants Committee Panel B (1992-1996); Wellcome Trust Molecular and Cell Panel (1998-2003) - Chair 2000-2003; Chair of Cancer Research UK's Biological Sciences Grants Committee 2004-2008; Cancer Research UK's Executive Director of Science 2005-2008 

Research

I study the molecular basis of cell adhesion to the extracellular matrix in normal and malignant cells. In particular we have focussed on cytoplasmic proteins such as talin and vinculin that couple the intern family of cell adhesion molecules to the actin cytoskeleton

Publications

Publications

(0) Talins and kindlins: partners in integrin-mediated adhesion.
Calderwood DA, Campbell ID, Critchley DR.Nat Rev Mol Cell Biol. 2013 Aug;14(8):503-17. doi: 10.1038/nrm3624. Epub 2013 Jul 17.PMID: 23860236 

Endothelial cell talin1 is essential for embryonic angiogenesis.
Monkley SJ, Kostourou V, Spence L, Petrich B, Coleman S, Ginsberg MH, Pritchard CA, Critchley DR.Dev Biol. 2011 Jan 15;349(2):494-502. doi: 10.1016/j.ydbio.2010.11.010. Epub 2010 Nov 26.PMID: 21081121

The Structure of the talin head reveals a novel extended conformation of the FERM domain.
Elliott PR, Goult BT, Kopp PM, Bate N, Grossmann JG, Roberts GC, Critchley DR, Barsukov IL.Structure. 2010 Oct 13;18(10):1289-99. doi: 10.1016/j.str.2010.07.011.PMID: 20947018

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Goult BT, Bouaouina M, Elliott PR, Bate N, Patel B, Gingras AR, Grossmann JG, Roberts GC, Calderwood DA, Critchley DR, Barsukov IL.EMBO J. 2010 Mar 17;29(6):1069-80. doi: 10.1038/emboj.2010.4. Epub 2010 Feb 11.PMID: 20150896

The structure of the C-terminal actin-binding domain of talin.
Gingras AR, Bate N, Goult BT, Hazelwood L, Canestrelli I, Grossmann JG, Liu H, Putz NS, Roberts GC, Volkmann N, Hanein D, Barsukov IL, Critchley DR.EMBO J. 2008 Jan 23;27(2):458-69. doi: 10.1038/sj.emboj.7601965. Epub 2007 Dec 20.PMID: 18157087 

Talin depletion reveals independence of initial cell spreading from integrin activation and traction.
Zhang X, Jiang G, Cai Y, Monkley SJ, Critchley DR, Sheetz MP.Nat Cell Biol. 2008 Sep;10(9):1062-8. doi: 10.1038/ncb1765.PMID: 19160486

Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.
Gingras AR, Ziegler WH, Frank R, Barsukov IL, Roberts GC, Critchley DR, Emsley J.J Biol Chem. 2005 Nov 4;280(44):37217-24. doi: 10.1074/jbc.M508060200. Epub 2005 Aug 30.PMID: 16135522

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.
Papagrigoriou E, Gingras AR, Barsukov IL, Bate N, Fillingham IJ, Patel B, Frank R, Ziegler WH, Roberts GC, Critchley DR, Emsley J.EMBO J. 2004 Aug 4;23(15):2942-51. doi: 10.1038/sj.emboj.7600285. Epub 2004 Jul 22.PMID: 15272303

Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated embryonic stem cells.
Priddle H, Hemmings L, Monkley S, Woods A, Patel B, Sutton D, Dunn GA, Zicha D, Critchley DR.J Cell Biol. 1998 Aug 24;142(4):1121-33. doi: 10.1083/jcb.142.4.1121.PMID: 9722622

Analysis of the actin-binding domain of alpha-actinin by mutagenesis and demonstration that dystrophin contains a functionally homologous domain.
Hemmings L, Kuhlman PA, Critchley DR.J Cell Biol. 1992 Mar;116(6):1369-80. doi: 10.1083/jcb.116.6.1369.PMID: 1541634.

Supervision

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Teaching

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Press and media

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Activities

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Awards

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Conferences

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