Our trials
All trials are conducted in a manner which ensures that the rights, safety and well-being of research participants are protected. This is especially true of any research data, which we utilise in accordance with GDPR and the Data Protection Act 2018.
ASSERT
Trial name: ASSERT
Trial title: The ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation) Randomised Controlled, Feasibility in Older People Trial
Trial type: Rehabilitation
Chief investigator: Professor Opinder Sahota
BEAT Severe Asthma
Trial name: BEAT Severe Asthma
Trial title: BEyond Allergic Th2 Severe Asthma
Trial type: Respiratory
Chief investigator: Professor Salman Siddiqui
BRIGhTMIND
Trial name: BRIGhTMIND
Trial title: Randomised double-blind controlled trial of connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment resistant moderate to severe depression: evaluation of efficacy, cost effectiveness and mechanism of action
Trial type: Mental Health
Chief investigator: Professor Richard Morriss
Chronic Breathlessness Cohort Study
Trial name: Chronic Breathlessness Cohort Study
Trial title: An exploratory study in older adults presenting with undifferentiated chronic breathlessness to understand the future risk and potential prognostic factors of disability, impaired health status, healthcare utilisation, and mortality
Trial type: Respiratory
Chief investigator: Associate Professor Rachael Evans
COLO-PREVENT
Trial name: COLO-PREVENT
Trial Title: A platform for developing COLOrectal cancer PREVENTion therapies
Trial Type: Gastroenterology
Chief Investigator: Professor Anne Thomas
COPD-HELP
Trial name: COPD-HELP
Trial title: A Randomised Controlled Trial of Mepolizumab Initiated During Admission to Hospital for a Severe Exacerbation of Eosinophilic COPD
Trial type: Respiratory
Chief investigator: Professor Chris Brightling
COPD-ST2OP
Trial name: COPD-ST2OP
Trial title: A randomised placebo-controlled trial of anti-ST2 in COPD
Trial type: Respiratory
Chief investigator: Professor Chris Brightling
EASY-AS
Trial name: EASY-AS
Trial title: A Randomised Controlled Trial of Early valve replacement in severe ASYmptomatic Aortic Stenosis.
Trial type: Cardiovascular
Chief investigators: Professor Gerry McCann (UK) and Professor Graham Hillis (Australia)
EXTOD Education
Trial name: EXTOD Education
Trial title: Supporting adults with Type 1 Diabetes (T1DM) to undertake exercise; Developing and piloting an Education programme for exercise in Type 1 diabetes: EXercise for Type 1 Diabetes (EXTOD) education
Trial type: Type 1 Diabetes
Chief Investigator: Professor Robert Andrews
MiST
Trial name: MiST
Trial title: Mesothelioma Stratified Therapy (MiST): A stratified multi-arm phase IIa clinical trial to enable accelerated evaluation of targeted therapies for relapsed malignant mesothelioma
Trial type: Cancer
Chief investigator: Professor Dean Fennell
NightLife
Trial name: NightLife
Trial title: A randomised controlled trial assessing the effectiveness and cost effectiveness of thrice weekly, extended, in-centre nocturnal haemodialysis versus standard care using a mixed methods approach (NightLife)
Trial type: Renal
Chief investigator: Professor James Burton
PERFORM
Trial name: PERFORM
Trial title: PERFORM (Personalised Exercise-Rehabilitation For people with Multiple long-term conditions (multimorbidity)) trial – WP3 Feasibility Study
Trial type: Multimorbidity Rehabilitation
Chief Investigator: Professor Sally Singh
PHAST
Trial name: PHAST
Trial title: A feasibility study to evaluate acceptability, uptake and effect of combined peripheral arterial disease, high blood pressure and abdominal aortic aneurysm screening (PHAST-F)
Trial Type: Cardiovascular
Chief Investigator: Professor Matt Bown
RapidNSTEMI
Trial name: RapidNSTEMI
Trial title: A randomised controlled trial of very early angiography +/- intervention versus standard of care on outcomes in patients with non ST-elevation myocardial infarction
Trial type: Cardiovascular
Chief investigator: Professor Adrian Banning
ROMA
Trial name: ROMA
Trial title: Randomised comparison of the clinical Outcome of single versus Multiple Arterial grafts: The ROMA trial
Trial type: Cardiovascular
Chief investigator: Professor Gavin Murphy (UK)
SMART Work and Life
Trial name: SMART Work and Life
Trial title: A three arm cluster randomised controlled trial to test the effectiveness and cost-effectiveness of the SMART Work & Life intervention for reducing daily sitting time in office workers
Trial type: Lifestyle
Chief investigator: Dr Charlotte Edwardson
SSCART
Trial name: SSCART
Trial title: A double blind, placebo controlled, randomised dose escalation trial to investigate the safety and efficacy of topical salbutamol in the improvement of scar appearance when applied to approximated wound margins in healthy volunteers
Trial type: Dermatology
Chief investigator: Dr Graham Johnston
Surviving Crying
Trial name: Surviving Crying
Trial Title: Cluster Randomised Controlled Trial of a Service to Support the Mental Health and Coping of Parents with Excessively Crying Infants
Trial Type: Mental Health
Chief Investigator: Professor Jayne Brown
TRiCSIV
Trial name: TRiCS.IV
Trial title: The UK Arm of the Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery Trial (TRiCS IV)
Trial type: Cardiac surgery and transfusion
Chief Investigator: Professor Gavin Murphy (UK)