People

Dr Steve Ennion

Phase 1 Director and Senior Tutor Leicester Medical School

School/Department: Leicester Medical School

Telephone: +44 (0)116 252 5100

Email: se15@leicester.ac.uk

Profile

Following a 5 year fellowship at the Royal Free Hospital studying how myosin heavy chain gene expression is controlled with age and exercise I subsequently moved to the University of Leicester as a Postdoctoral research fellow where my research switched focus to the P2X family of ligand gated cation channels. These receptors are activated by extracellular ATP and play important roles in a wide variety of physiological processes such as neurotransmission, smooth muscle contraction, platelet activation and immune cell function. My main contributions to this field were to identify the location of the agonist binding site, to demonstrate agonist induced internalisation and rapid re-cycling in native P2X1 receptors and to map the cysteine partner residues of the 5 disulphide bonds present in the extracellular loop. After subsequently gaining a lectureship at the University of Leicester my research focused on P2X receptors in lower organisms as a models for understanding the molecular function of this class of receptor.

In 2015 I moved to a teaching dominant role within Leicester Medical School where I am currently Phase 1 Director and the Senior Tutor.

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