Dr Shameem S Ladak

Shameem is a Research Associate in Professor Gavin Murphy’s research group. She worked as a postdoctoral researcher at the cardiovascular department, Johns Hopkins University, USA (2018-2019).Shameem obtained her PhD in Immunology and lung transplantation in 2018 following an MRes in immunobiology in 2013 from Newcastle University

Shameem’s research is focused on the vein graft study. Her work involves studying the role of acute shear stress in vein graft disease under the guidance of Mr Mustafa Zakkar using an in vitro and ex vivo shear stress model. The main focus of her study is to identify the immediate changes in different cell layers of veins and interactions between them when they are implanted in a new haemodynamic environment with an aim to offer personalised preventive interventions for patients undergoing coronary bypass graft surgery. In addition to this, Shameem consents patients and records data in CRF.

Shameem is also actively involved in the other ongoing clinical trials including VAL-CARD and Ob-CARD trial and is responsible for processing bloods and samples as per the protocol.

KEY PUBLICATIONS:

Ladak, S., McQueen, L., Tomkova, K., Adebayo, A., Suleiman, M.S., George, S., Murphy, G. and ZAKKAR, M., 2023. Dexamethasone modulate TWIST mediated EndMT changes in venous EC under acute shear stress. Implications for vein grafts disease. medRxiv, pp.2023-05. https://doi.org/10.1101/2023.05.26.23290570

Layton, G.R., Ladak, S.S., Abbasciano, R., McQueen, L.W., George, S.J., Murphy, G.J. and Zakkar, M., 2023. The Role of Preservation Solutions upon Saphenous Vein Endothelial Integrity and Function: Systematic Review and UK Practice Survey. Cells, 12(5), p.815. https://doi.org/10.3390/cells12050815

Ladak, S.S., McQueen, L.W., Layton, G.R., Aujla, H., Adebayo, A. and Zakkar, M., 2022. The Role of Endothelial Cells in the Onset, Development and Modulation of Vein Graft Disease. Cells, 11(19), p.3066. https://doi.org/10.3390/cells11193066

McQueen, L.W*., Ladak, S.S*. and Zakkar, M., 2022. Acute shear stress and vein graft disease. The International Journal of Biochemistry & Cell Biology, 144, p.106173. https://doi.org/10.1016/j.biocel.2022.106173 . *Joint first co-authors

Fashina, O., Abbasciano, R.G., McQueen, L.W., Ladak, S., George, S.J., Suleiman, S., Punjabi, P.P., Angelini, G.D. and Zakkar, M., 2023. Large animal model of vein grafts intimal hyperplasia: A systematic review. Perfusion, 38(5), pp.894-930. https://doi.org/10.1177/02676591221091200

McQueen, L.W., Ladak, S.S., Abbasciano, R., George, S.J., Suleiman, M., Angelini, G.D., Murphy, G.J. and Zakkar, M., 2022. Next-Generation and Single-Cell Sequencing Approaches to Study Atherosclerosis and Vascular Inflammation Pathophysiology: A Systematic Review. Frontiers in Cardiovascular Medicine, 9, p.849675https://doi.org/10.3389/fcvm.2022.849675

Thompson, E.R., Sewpaul, A., Figuereido, R., Bates, L., Tingle, S.J., Ferdinand, J.R., Situmorang, G.R., Ladak, S.S., Connelly, C.M., Hosgood, S.A. and Nicholson, M.L., 2022. MicroRNA antagonist therapy during normothermic machine perfusion of donor kidneys. American Journal of Transplantation, 22(4), pp.1088-1100. https://doi.org/10.1111/ajt.16929

Ward, A.O., Sala-Newby, G.B., Ladak, S., Angelini, G.D., Caputo, M., Suleiman, M.S., Evans, P.C., George, S.J. and Zakkar, M., 2022. Nrf2-Keap-1 imbalance under acute shear stress induces inflammatory response in venous endothelial cells. Perfusion, 37(6), pp.582-589. https://doi.org/10.1177/02676591211012571

Ladak, S.S., Roebuck, E., Powell, J., Fisher, A.J., Ward, C. and Ali, S., 2019. The Role of miR-200b-3p in Modulating TGF-β1–induced Injury in Human Bronchial Epithelial Cells. Transplantation, 103(11), pp.2275-2286. DOI: 10.1097/TP.0000000000002845

Aldhahrani, A., Powell, J., Ladak, S., Ali, M., Ali, S., Verdon, B., Pearson, J. and Ward, C., 2018. The potential role of bile acids in acquired laryngotracheal stenosis. The Laryngoscope, 128(9), pp.2029-2033. https://doi.org/10.1002/lary.27105

Ladak, S.S., Ward, C. and Ali, S., 2016. The potential role of microRNAs in lung allograft rejection. The Journal of Heart and Lung Transplantation, 35(5), pp.550-559. https://doi.org/10.1016/j.healun.2016.03.018

CONFERENCE ABSTRACTS:

Ladak S, McQueen L, JoelDavid L, et al. BS36 Acute arterial haemodynamics activation of endothelial to mesenchymal transition in long saphenous veins. Impact on vein graft disease. Heart 2022;108:A165-A166.

McQueen L, Ladak S, Tavares A, et alBS20 Dexamethasone inhibits opn-activation associated with intimal hyperplasia in vein grafts. Heart 2022;108:A156-A158.

Sewpaul, Avinash; Figueiredo, Rodrigo S; Bates, Lucy; Tingle, Samuel J; Ladak, Shameem S; Thompson, Emily; Stamp, Susan; Scott, William E III; Hosgood, Sarah A; Nicholson, Michael L; Ali, Simi1,; Sheerin, Neil; Wilson, Colin H. Modifying Renal Gene Expression by Anti-Sense Oligonucleotide Delivery during Normothermic Machine Perfusion. Transplantation 102():p S728, July 2018. DOI: 10.1097/01.tp.0000543708.68424.93

Ladak, S.S., Ward, C. and Ali, S. MiRNA-200b inhibits epithelial-mesenchymal transition in TGF-β1 induced human bronchial epithelial cells. European Respiratory Journal 2016 48: PA4034; DOI:10.1183/13993003.congress2016.PA4034

Okonkwo, A., Ladak, S., Ali, S. and Kirby, J., 2013. Kidney transplantation: chronic molecular signatures in acute kidney injury. In Annual Congress of the British Society for Immunology. Newcastle University. https://doi.org/10.1111/imm.12184

Non-BSCR Travel Award, UK, 2022

BSCR Travel Award, UK, 2022

Travel award - Joint BAS / BSCR meeting at the BCS conference, 2022

BCS Conference Travel Grant, 2022

Post-submission academic scholarship, Newcastle University, 2017

York Science Fellowship, York University, Canada (Withdrawn), 2017

Overseas research scholarship (ORS), Newcastle University, 2013-2016

SCTS Annual meeting, March 2023- Oral presentation

British Atherosclerosis Society Annual Conference, Sep 2022 - Poster presentation

British Cardiovascular Society Annual Conference, June 2022- Oral presentation

PhD in Immunobiology September 2013- February 2018, Newcastle University

Mres Immunobiology, 2012 – 2013, Newcastle University

M.Tech integrated degree in Biotechnology and Bioinformatics , 2006-2011, Padmashree Dr D.Y.Patil University, Department of Biotechnology and Bioinformatics