Dr Mark Leyland

After graduating with a degree in biochemistry I gained a PhD in molecular biology at the University of Sheffield. Following post-doctoral work I joined the Department of Biochemisty at Leicester as a lecturer. I am now a teaching-focused member of staff and teach widely in 1st Year Biological Sciences and in the biochemistry/medical biochemistry programme.

Research interests: Ion channels and receptors in mast cells

Structure and function of ion channel scaffolding proteins

Moiseeva EP, Straatman KR, Leyland ML, Bradding P. (2014). CADM1 controls actin cytoskeleton assembly and regulates extracellular matrix adhesion in human mast cells. PLoS One 9(1), e85980. doi:10.1371/journal.pone.0085980.
Ashmole, I., Duffy, S. M., Leyland, M. L. and Bradding, P. (2013). The contribution of Orai(CRACM)1 and Orai(CRACM)2 channels in store-operated Ca2+ entry and mediator release in human lung mast cells. PLoS One 8(9), e74895. 
Moiseeva, E. P., Roach, K. M., Leyland, M. L., & Bradding, P. (2013). CADM1 is a key receptor mediating human mast cell adhesion to human lung fibroblasts and airway smooth muscle cells.. PLoS One, 8(4), e61579. doi:10.1371/journal.pone.0061579
Moiseeva, E. P., Leyland, M. L., & Bradding, P. (2013). CADM1 is expressed as multiple alternatively spliced functional and dysfunctional isoforms in human mast cells.. Mol Immunol, 53(4), 345-354. doi:10.1016/j.molimm.2012.08.024
Ashmole, I., Duffy, S. M., Leyland, M. L., Morrison, V. S., Begg, M., & Bradding, P. (2012). CRACM/Orai ion channel expression and function in human lung mast cells.. J Allergy Clin Immunol, 129(6), 1628-35.e2. doi:10.1016/j.jaci.2012.01.070
Moiseeva, E. P., Leyland, M. L., & Bradding, P. (2012). CADM1 isoforms differentially regulate human mast cell survival and homotypic adhesion. Cellular and Molecular Life Sciences, 69, 2751-2764. doi:10.1007/s00018-012-0948-y

No

BS1030 The Molecules of LIfe - module convenor

BS2093 Protein Control in Cellular Regulation - module convenor

BS2014 contributor

Final Year project supervisor

University Distinguished Teaching Fellow