Dr Hollie Marshall

Dr Marshall is a Lecturer in Genomics, specialising in epigenomic data.

She did her first degree in Animal Biology at the University of Worcester in 2012, followed by a couple of years work outside of academia. Dr Marshall then carried out a masters by research degree in the lab of Prof Luisa Orsini at the University of Birmingham in 2014. This work focused on ecological genetics of natural populations of Daphnia. 

In 2015 she started her PhD with Prof Eamonn Mallon at the University of Leicester, working on epigenetic mechanisms (DNA methylation) in bumblebees as a test for imprinted gene evolutionary theory. During this time she also continued her collaboration with Prof Orsini, to apply epigenomics to natural populations.

Dr Marshall then carried out a postdoc position at the University of Edinburgh with Dr Larua Ross, exploring the epigenomic mechanisms of whole chromosome imprinting in an agricultural pest species. She then returned to Leicester for a postdoc in Prof Mallon's lab, looking at genome/epigenome interactions in jewel wasps.

In 2023 she started her lab within the Department of Genetics and Genome Biology focusing on environmentally induced transgenerational inheritance, see lab website here: https://mooholl.github.io/.

The lab focuses on epigenetic transgenerational inheritance in arthropod model organisms (i.e. insects and crustaceans). Specifically:

- transgenerational consequences of environmental exposure, e.g. chemical pollution, microplastics, climate change

- epigenetic mechanisms as biomarkers of exposure and population health, with application to species conservation

- the role of epigenetic mechanisms in species adaptation to environmental change, i.e. population epigenomics

Mongue, A. J., Woodman, T., Marshall, H., Garber, A. J., Franco, J. C., McCutcheon, J. P. and Ross, L. (2024). Paternal genome elimination creates contrasting evolutionary trajectories in male and female citrus mealybugs. bioRxiv. https://doi.org/10.1101/2024.07.28.604693

Devilliers, J., Marshall, H., Warren, B., Kyriacou, C. P., Araripe, L. O., Bruno, R. V., Rosato, E. and Feuda, R. (2024). Molecular correlates of swarming behaviour in Aedes aegypti males. Biology Letters. Accepted.

Hunt, B. J., Pegoraro, M., Marshall, H. and Mallon, E. B. (2023). A role for DNA methylation in bumblebee morphogenesis hints at female-specific developmental erasure. Insect Molecular Biology. 33 (5), 481-492.

Marshall, H.*, de la Filia, A. G.*, Cavalieri, R., Mallon, E. B., Clark, J. M. and Ross, L. (2023). Lack of paternal silencing and ecotype-specific expression in head and body lice hybrids. Evolution Letters. 8 (3), 455-465.

Chaturvedi, A.*, Dhandapani, V.*, Li, X.*, Marshall, H.*, Kissane, S., Cucena Cambronero, M., Asole, G., Calvet, F., Ruiz-Romero, M., Marangio, P., Guigo, R., Rago, D., Mirbahai, L., Eastwood, N., Colbourne, J. K., Mallon, E. B. and Orsini, L. (2023). The hologenome of Daphnia magna reveals possible DNA methylation and microbiome-mediated evolution of the host genome. Nucleic Acids Research. 51 (18), p9785–9803.

Yu, X.*, Marshall, H.*, Yu, H., Liu, Y., Xiong, Y., Zeng, X., Yu, H., Chen, W., Zhou, G., Zhu, B., Ross, L. and Lu, Z. (2023). Sex-specific transcription and DNA methylation landscapes of the Asian citrus psyllid, a vector of huanglongbing pathogens. Evolution. 7(5), p1203–1215.

Marshall, H., Nicholas, M. T., van Zweden, J.S., Wäckers, F., Ross, L., Wenseleers, T. and Mallon, E.B. (2023). DNA methylation is associated with codon degeneracy in a species of bumblebee. Heredity. 130, p188–195.

Cuenca Cambronero, M., Pantel, J., Marshall, H., Nguyen, T., Tomero-Sanz, H. and Orsini, L. (2021). Evolutionary mechanisms underpinning fitness response to multiple stressors in Daphnia. Evolutionary Applications. 14(10), p2457-2469.

Bain, S.*, Marshall, H.*, de la Filia, A. G., Laetsch, D. R., Husnik, F. and Ross, L. (2021) Sex-specific expression and DNA methylation in a species with extreme sexual dimorphism and paternal genome elimination. Molecular Ecology. 30(22), p5687-5703. * Joint 1st authorship.

Cuenca Cambronero, M., Pantel, J., Marshall, H., Nguyen, T., Tomero-Sanz, H. and Orsini, L. (2021) Evolutionary mechanisms underpinning fitness response to multiple stressors in Daphnia.  Evolutionary Applications. 14(10), p2457-2469.

Marshall, H., van Zweden, J.S., Van Geystelen, A., Benaets, K., Wackers, F., Mallon, E.B. and Wenseleers, T. (2020). Parent of origin gene expression in the bumblebee, Bombus terrestris, supports Haigs kinship theory for the evolution of genomic imprinting. Evolution Letters. 4 (6), p479-490.

Marshall, H., Jones, A., Lonsdale, Z.N. and Mallon, E.B. (2020). Bumblebee worker castes show differences in allele-specific DNA methylation and allele-specific expression. Genome Biology and Evolution. 12 (8), p1471-1481.

Marshall, H., Lonsdale, Z.N. and Mallon, E.B. (2019). Methylation and gene expression differences between bumblebee reproductive castes. Evolution Letters. 3 (5), p485-499.

Bebane, P., Hunt, B., Pegoraro, M., Jones, A.R.C., Marshall, H., Rosato, E. and Mallon, E.B. (2019). The effects of the neonicotinoid imidacloprid on gene expression and DNA methylation in the buff-tailed bumblebee Bombus terrestris. Proc. Roy. Soc. B. 286: 20190718.

Cambronero, M., Marshall, H., De Meester, L., Davidson, T.A., Beckerman, A.P. and Orsini, L. (2018). Predictability of the impact of multiple stressors on the keystone species Daphnia. Scientific Reports. 8 (1), p17572.

Pegoraro, M., Marshall, H., Lonsdale, Z.N. and Mallon, E.B. (2017). Do social insects support Haig's kin theory for the evolution of genomic imprinting? Epigenetics. 12 (9), p725-742.

Orsini, L., Marshall, H., Cuenca-Cambronero, M., Chaturvedi, A., Thomas, K. W., Pfrender, M.E., Spanier, K.I. and De Meester, L. (2016) Temporal genetic stability in natural populations of the waterflea Daphnia magna in response to strong selection pressure. Molecular Ecology. 25 (24), p6009-6267.

Transgenerational consequences of pollution (non-human focus)

Epigenetics in wild populations