Dr Harvinder Virk
NIHR Academic Clinical Lecturer Respiratory Sciences
School/Department: Respiratory Sciences, Department of
Email: hsv6@leicester.ac.uk
Web:
Only Good Antibodies Co-founder UK Reproducibility Network Supervisory Board
Profile
Supervisory Board Representative UK Reproducibility Network
Only Good Antibodies Co-founder
Publications
Publications 2023-2024
- *Biddle, Michael, et al."Improving the integrity and reproducibility of research that uses antibodies: a technical, data sharing, behavioral and policy challenge", mAbs (2024), 16:1, https://doi.org/10.1080/19420862.2024.2323706
- Tsaknis, G; Virk H. "Assessment of solitary pulmonary nodule", BMJ Best Practice (2024). (Online Resource)
- Ayoubi, Riham, et al. "Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications." eLife 12:RP91645. (2023) https://doi.org/10.7554/eLife.91645.2 (lead UK author - designed analysis and contributed resources)
- *Biddle, Michael and Virk, Harvinder S.” YCharOS Open Antibody Characterisation Data: Lessons Learned and Progress Made.” F1000Research 12 (2023). https://doi.org/10.12688/f1000research.141719.1
- Kahn, Richard A., Harvinder S. Virk, and Peter S. McPherson. "Heed a decade of calls for antibody validation." Nature 620.7974 (2023): 492. https://doi.org/10.1038/d41586-023-02566-w
- **Aponte Santiago, Nicole, et al. "Tales of the unexpected." eLife 12 (2023): e87444. https://doi.org/10.7554/eLife.87444
**Co-first author *Corresponding author
Preprints
- Leavy, Olivia, et al. "Genome-wide SNP-sex interaction analysis of susceptibility to idiopathic pulmonary fibrosis." medRxiv (2024).01.12.24301204; doi: https://doi.org/10.1101/2024.01.12.24301204
- Ayoubi, Riham, et al. A consensus platform for antibody characterization, 11 April 2024, PROTOCOL (Version 1) available at Protocol Exchange https://doi.org/10.21203/rs.3.pex-2607/v1 (lead UK author)
Teaching
Awards
Current projects/ funding:-
NIHR INSPIRE Network INDEX (Interstitial Lung Disease Exacerbation) Study - National observational study to understand heterogeneity in care, management and outcomes of acute exacerbations of ILD
Biomarker discovery and target validation utilising the YCharOS antibody characterisation pipeline. Medical Research Council (Leicester) 2024-02 to 2024-11 | Locally awarded MRC Impact Accelerator with support from Leicester Drug Discovery and Diagnostics (PI)
The Only Good Antibodies Community Stakeholder Engagement Meeting. Biotechnology and Biological Sciences Research Council (Swindon). 2023-06 to 2024-03 | Locally awarded BBSRC Impact Accelerator, Event (PI)
Knowledge and skills exchange to lay the foundations for the international expansion of YCharOS: an Open Science, third party antibody characterisation public good company. Biotechnology and Biological Sciences Research Council IAA (Swindon). 2023-06 to 2024-03 | Locally awarded BBSRC Impact Accelerator, Exchange (PI)
Using fluorescent biosensors to understand mechanisms of lung ageing. Biotechnology and Biological Sciences Research Council (Swindon).(Co-PI) 2023-06 to 2024-03 | Locally awarded BBSRC Impact Accelerator, Proof of concept
Pioneering Partnerships: Identifying and addressing human and research culture factors driving the insufficient validation of antibodies in biomedical research
University of Leicester (Leicester)
2022-10 to 2023-08 | Local award
Previous awards:
Redox sensitive TRP ion channels in the interaction between human lung mast cells and oxidative stress
Medical Research Council (London)
2016-03-31 to 2019-08-31 | MRC Clinical Research Training Fellowship
TRP ion channels as sensors and modulators of oxidative stress in allergic inflammation and asthma.
Midlands Asthma and Allergy Research Association (Leicester)
2014-10 to 2015-10 | small grant
Qualifications
University of Leicester, MRes with distinction, 2012 - 2016
Royal College of Physicians, MRCP (UK), 2013
University of Birmingham, MBChB (Hons) and 4 distinctions, 2005 - 2010
Oxford University Experimental Psychology MA (Oxon), 2002 – 2005