People

Dr Esther Moss

Associate Professor of Gynaecological Oncology

School/Department: Genetics and Genome Biology, Department of

Email: em321@leicester.ac.uk

Profile

Whilst studying medicine at the University of Birmingham, Esther Moss developed an interest in gynaecological oncology and furthered this by studying for an MSc in Clinical Oncology, also at the University of Birmingham. Esther was awarded a Wellbeing of Women Research Training Fellowship in order to undertake a PhD at Keele University investigating molecular control of carboplatin resistance in ovarian cancer cells. Dr Moss was awarded the Edgar Gentilli Prize by the Royal College of Obstetricians and Gynaecologists for this original research.

Following subspecialty training Dr Moss was appointed as a consultant gynaecological oncologist at the University Hospitals of Leicester in 2012, instigating a programme of gynaecological oncology research and subsequently establishing the Leicester Gynaecological Cancer Research Group (LGCRG) which is now an integral part of the Leicester Cancer Research Centre and Experimental Cancer Medicine Centre.

 

Research

Dr Moss’ focus for research inspiration comes from clinical challenges and listening to patients, with the aim of translating laboratory developments into the clinical setting in order to impact the everyday lives of patients.

Dr Moss’ research currently focuses on:

  • Endometrial cancer genetics
    • In particular their impact on the sensitivity of endometrial cancer to drug therapy (chemotherapy and immunotherapy)
  • Personalising endometrial cancer follow-up and survivorship 
  • Interventions to improve survivorship following treatment for cervical cancer
  • Surgeon ergonomics
 

Publications

Millet N, Moss EL, Munir F, Rogers E, McDermott HJ. An exploration of the recovery process and return to daily activity in women treated for cervical cancer. European Journal of Cancer Care 2022; 31(2):e13560

Millet N, McDermott HJ, Munir F, Edwardson C, Moss EL. ACCEPTANCE: Protocol for a feasibility study of a multicomponent physical activity intervention following treatment for cervical cancer. BMJ Open 2022;12:e048203

Morrison J, Balega J, Buckley L, Clamp A, Crosbie E, Drew Y, Durrant Lisa, Forrest J, Fotopoulou C, Gajjar K, Gupta J, Hughes J, Miles T, Moss E, Priyadarshini Nanthakumar M, Ryan N, Walther A, Taylor A. British Gynaecological Cancer Society (BGCS) Uterine Cancer Guidelines: Recommendations for Practice. Eur J Obs Gyn Reprod Biol 2022;270:50-89

Sers R, Forrester S, Zecca M, Ward S, Moss EL. Objective assessment of surgeon kinematics during simulated laparoscopic surgery: a preliminary evaluation of the effect of high body mass index models. Journal of Computer Assisted Radiology and Surgery 2022;17(1):75-83

Wan JC, Mughal TI, Razavi P, Dawson S, Govindan R, Tan I, Yap Y, Moss EL, Morris C, Besse B, Bardelli A, Tie J, Kopetz S, Rosenfeld N. Liquid biospies for residual and recurrent disease. Med 2021;2(12):1292-1313

Mohammed S, Polymeros K, Wickham-Joseph R, Luqman I, Charadva C, Morris T, Collins A, Barber S, Khunti K, Moss EL. Comparing characteristics of endometrial cancer in South Asian and White ethnicity women in England. Cancers 2021;13(23):6123

Collins A, Motiwale T, Barney O, McParland P, Dudbridge F, Moss EL. Risk of preterm birth following excisional treatment for cervical intra-epithelial neoplasia: does previous obstetric history have greater impact than depth of excision? Acta Obs Gynecol Scand 2021;100:1995-2002

Sers R, Forrester S, Zecca M, Ward S, Moss EL. The ergonomic impact of patient body mass index on surgeon posture during simulated laparoscopy. Applied ergonomics 2021;97:103501

Collins, Taylor A, Guttery DS, Moss EL. Innovative follow-up strategies for Endometrial Cancer. Clinical Oncology 2021;33:e383-392

Relton A, Collins A, Guttery DS, Gorsia D, McDermott HJ, Moss EL. Patient acceptability of ctDNA testing in endometrial cancer follow-up.  European Journal of Cancer Care 2021:e13429

Collins A, Miles GJ, Powley I, Hew R, Pringle JH, MacFarlane M, Pritchard C, Moss EL. Development of a Patient-Derived Explant model for prediction of drug responses in endometrial cancer. Gynecologic Oncology 2021;160(2):557-567

Moss EL, Morgan, Martin A, Sarhanis P, Ind T. Surgical trends, outcomes and disparities in minimal invasive surgery for women with endometrial cancer in England: A retrospective cohort study. BMJ Open 2020; 10(9):e036222

Moss EL, Gorsia DN, Collins A, Sandhu P, Foreman N, Gore A, Wood J, Kent C, Stannard EA, Silcock L, Guttery DS. Utility of circulating tumor DNA for detection and monitoring of endometrial cancer recurrence and progression. Cancers 2020;12:2231

Luqman I, Wickham-Joseph R, Cooper N, Boulter L, Patel N, Moss EL. Patient-Initiated Follow-Up for Low-Risk Endometrial Cancer: An economic analysis. International Journal Gynecological Cancer 2020;30(7):1000-4

Collins A, Miles G, Wood J, MacFarlane M, Pritchard C, Moss EL. Patient-derived explants, xenografts and organoids: 3-dimensional patient-relevant pre-clinical models in endometrial cancer. Gynecologic Oncology 2020;156(1):251-259

Patel H, Sherman SM, Moss EL. HPV primary screening for cervical cancer: Is it an acceptable test for women in England? Psycho-oncology 2018;27(6):1559-1564

Arbyn M, Redman CWE, Verdoodt F, Tzafettas M, Kyrgiou M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL. Incomplete excision of cervical pre-cancer as predictor of treatment failure: A systematic review and meta-analysis. Lancet Oncology 2017; 18(12):1665-1679

Kumarakulasingam P, McDermott H, Patel N, Boulter L, Tincello DG, Peel D, Moss EL. Acceptability and utilisation of patient-intiated follow-up (PIFU) for endometrial cancer amongst women from diverse ethnic and social backgrounds. European Journal of Cancer Care 2019;28(2):e12997

Supervision

Dr Moss supervises projects in the areas of:

  • Personalising gynaecological cancer treatment and follow-up
  • Mechanisms of drug resistance in gynaecological cancers
  • Surgeon ergonomics

Teaching

Dr Moss teaches on the following courses:
  • Intercalated MSc in Medical Research
  • BSc in Clinical Genetics
  • MSc in Cancer Molecular Pathology and Therapeutics
 

Press and media

Endometrial cancer follow-up

Surgeon ergonomics

Activities

Professional membership:

  • Royal College of Obstetricians and Gynaecologists
  • British Gynaecological Cancer Society
  • European Society of Gynaecological Oncology
  • British Society of Colposcopy and Cervical Pathology
  • British and Irish Association of Robotic Gynaecological Surgeons
  • Birmingham and Midlands Obstetrical and Gynaecological Society

Awards

Dr Moss was awarded the Sims-Black Travelling Professorship by the Royal College of Obstetricians and Gynaecologists in 2015 to jointly lead a team of experts in colposcopy, pathology and public health to Riga StradiƆš University, Latvia, in order to explore the barriers and challenges to participation in the Latvian Cervical Screening programme.

Conferences

Dr Moss has led the organisation of the following conferences and meetings:

  • 2015 Birmingham and Midlands Obstetrical and Gynaecological Society scientific meeting (BMOGS) (Leicester)
  • 2017 British and Irish Association of Robotic Gynaecological Surgeons Annual Academic conference (Leicester)
  • 2017 Joint BMOGS and Latvian Gynaecological Society scientific meeting (Riga Latvia)
  • 2018 Human factors in Gynaecological Oncology course (Leicester)
  • 2020 Personalising follow-up for endometrial cancer (virtual)
 

Qualifications

MB ChB - University of Birmingham

MSc in Clinical Oncology - University of Birmingham

PhD Life Sciences - Keele University

Fellowship of the Royal College of Obstetricians and Gynaecologists

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