People

Dr Esther Moss

Associate Professor of Gynaecological Oncology

Profile

I studied medicine at the University of Birmingham. I developed an interest in gynaecological oncology and furthered this by undertaking an MSc in Clinical Oncology (University of Birmingham). I was awarded a Wellbeing of Women Research Training Fellowship in order to undertake research a PhD (Keele University) investigating ‘Molecular control of carboplatin resistance in ovarian cancer cells’. I was awarded the Edgar Gentilli Prize (Royal College of Obstetricians and Gynaecologists) for my original research. Following subspecialty training I was appointed as a Consultant Gynaeclogical Oncologist at the University Hospitals of Leicester in 2012. I instigated a programme of gynaecological oncology research and subsequently established the Leicester Gynaecological Cancer Research Group (LGCRG) which is now an integral part of the Leicester Cancer Research Centre and Experimental Cancer Medicine Centre.

Research

I have always taken the focus for my research inspiration from clinical challenges and listening to patients with the aim of translating laboratory developments into the clinical setting in order to impact the everyday lives of patients.

The research I am leading currently focuses on:

- endometrial cancer genetics

- in particular their impact on the sensitivity of endometrial cancer to drug therapy (chemotherapy and immunotherapy)

- personalising endometrial cancer follow

- interventions to improve survivorship following treatment for cervical cancer

- surgeon ergonomics

Publications

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Innovative follow-up strategies for Endometrial Cancer. Collins, Taylor A, Guttery DS, Moss EL. Clinical Oncology 2021;33:e383-392

Patient acceptability of ctDNA testing in endometrial cancer follow-up. Relton A, Collins A, Guttery DS, Gorsia D, McDermott HJ, Moss EL.  European Journal of Cancer Care 2021:e13429

Development of a Patient-Derived Explant model for prediction of drug responses in endometrial cancer. Collins A, Miles GJ, Powley I, Hew R, Pringle JH, MacFarlane M, Pritchard C, Moss EL.  Gynecologic Oncology 2021;160(2):557-567

Surgical trends, outcomes and disparities in minimal invasive surgery for women with endometrial cancer in England: A retrospective cohort study. Moss EL, Morgan, Martin A, Sarhanis P, Ind T. BMJ Open 2020; 10(9):e036222

Utility of circulating tumor DNA for detection and monitoring of endometrial cancer recurrence and progression. Moss EL, Gorsia DN, Collins A, Sandhu P, Foreman N, Gore A, Wood J, Kent C, Stannard EA, Silcock L, Guttery DS. Cancers 2020;12:2231

Patient-Initiated Follow-Up for Low-Risk Endometrial Cancer: An economic analysis. Luqman I, Wickham-Joseph R, Cooper N, Boulter L, Patel N, Moss EL. International Journal Gynecological Cancer 2020;30(7):1000-4

Patient-derived explants, xenografts and organoids: 3-dimensional patient-relevant pre-clinical models in endometrial cancer. Collins A, Miles G, Wood J, MacFarlane M, Pritchard C, Moss EL. Gynecologic Oncology 2020;156(1):251-259

HPV primary screening for cervical cancer: Is it an acceptable test for women in England? Patel H, Sherman SM, Moss EL. Psycho-oncology 2018;27(6):1559-1564

Incomplete excision of cervical pre-cancer as predictor of treatment failure: A systematic review and meta-analysis. Arbyn M, Redman CWE, Verdoodt F, Tzafettas M, Kyrgiou M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL. Lancet Oncology 2017; 18(12):1665-1679

Acceptability and utilisation of patient-intiated follow-up (PIFU) for endometrial cancer amongst women from diverse ethnic and social backgrounds.  Kumarakulasingam P, McDermott H, Patel N, Boulter L, Tincello DG, Peel D, Moss EL. European Journal of Cancer Care 2019;28(2):e12997

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Supervision

Personalising gynaecological cancer treatment and follow-up

Mechanisms of drug resistance in gynaecological cancers

Surgeon ergonomics

Teaching

Intercalated MSc in Medical Research

BSc in Clinical Genetics

MSc in Cancer Molecular Pathology and Therapeutics

Press and media

Endometrial cancer follow-up

Surgeon ergonomics

Activities

Professional membership:

- Royal College of Obstetricians and Gynaecologists

- British Gynaecological Cancer Society

- European Society of Gynaecological Oncology

- British Society of Colposcopy and Cervical Pathology

- British and Irish Association of Robotic Gynaecological Surgeons

- Birmingham and Midlands Obstetrical and Gynaecological Society

Awards

I was awarded the Sims Black Travelling Professorship by the Royal College of Obstetricians and Gynaecologists in 2015 to jointly lead a team of experts in colposcopy pathology and public health to Riga Stadins University in order to explore the barriers and challenges to participation in the Latvian Cervical Screening programme.

Conferences

I have led the organisation of several conferences and meetings:

2015 Birmingham and Midlands Obstetrical and Gynaecological Society scientific meeting (BMOGS) (Leicester)

2017 British and Irish Association of Robotic Gynaecological Surgeons Annual Academic conference (Leicester)

2017 Joint BMOGS and Latvian Gynaecological Society scientific meeting (Riga Latvia)

2018 Human factors in Gynaecological Oncology course (Leicester)

2020 Personalising follow-up for endometrial cancer (virtual)

Qualifications

MB ChB - University of Birmingham

MSc in Clinical Oncology - University of Birmingham

PhD Life Sciences - Keele University

Fellowship of the Royal College of Obstetricians and Gynaecologists

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