Emmanuel Adonyo

I am a PhD student (expected completion - April 2025) in Genetic Epidemiology with a strong focus on public health genomics and GWAS in African populations. My research aims to identify the genetic determinants of complex traits, particularly lung function measures, across diverse populations.

I am particularly interested in leveraging the unique genetic diversity of African populations to advance our understanding of both genetic and environmental factors influencing respiratory health in sub-Saharan Africa. By analysing both epidemiological and large-scale genomic datasets, I aim to develop innovative approaches for disease prediction, prevention and intervention measures.

I am grateful for the opportunity to contribute to the growing field of genetic epidemiology and to work with a talented team of researchers here at the University of Leicester.

My research interests include:

• Genome-wide association studies (GWAS)
• Population genetics
• Statistical genetics
• Bioinformatics
• African genomics

Genetic Epidemiology of Respiratory Health in African Populations

My research focuses on understanding the genetic and environmental factors that contribute to respiratory health disparities in African populations. I am currently involved in several projects, including:

1. Genomic Studies of Lung Function – Conducting genome-wide association studies (GWAS) to identify genetic variants associated with lung function traits, such as forced expiratory volume in one second (FEV1) and forced vital capacity (FVC).
2. Epidemiology studies – Collaborating with African researchers to undertake epidemiological studies aiming at understanding non-genetic determinants of respiratory health in African continent.
3. Polygenic Risk Score Development and Refinement – Developing and refining polygenic risk scores (PRSs) for respiratory diseases, leveraging large-scale genomic data from diverse populations, including African populations.
4. Exploration of Environmental and Lifestyle Factors – Investigating the impact of environmental exposures, such as air pollution and tobacco smoke, and lifestyle factors, such as diet and physical activity, on lung function and respiratory disease risk.
5. Collaborative Research – Collaborating with international researchers to share data, expertise, and resources to advance the field of genetic epidemiology and improve global health outcomes.

Through these research activities, I aim to contribute to the development of precision medicine approaches for the prevention, diagnosis, and treatment of respiratory diseases, particularly in African populations.