Professor Elizabeta Mukaetova-Ladinska

I hold the Chair in Old Age Psychiatry. My academic interests are influenced both by my clinical and laboratory based educational and research background. I am driven by the objective of improving clinical outcomes from molecular and cellular discoveries, to the benefit of patients with cognitive and mental health impairments. This is reflected in my areas of academic interest that include: dementia, delirium, autism, and mental health of older people.

My research involves:

• (a) understanding the molecular substrates underlying age-associated cognitive impairment in elderly, and how they are related to the development of the two major neurodegenerative diseases, Alzheimer’s disease and dementia with Lewy bodies;
• (b) developing peripheral biomarkers with high sensitivity and specificity to detect various forms of dementia, and their implementation in routine clinical setting with an aim to monitor the progression of the disease and treatment (patented);
• (c) relating this knowledge to further neuropathological and neurobiochemical knowledge of ageing in neurodevelopmental disorders, such as ageing and neurodegeneration in Down syndrome and autism; and
• (d) relating the laboratory-based knowledge of aetiopathogenesis of dementia and ageing to
  • (i) clinical practice (neuropharmacology of cognitive impairment and behavioural problems in neurodegenerative diseases, delirium and depression) and
  • (ii) teaching old age psychiatry medicine to undergraduate and postgraduate students, trainees and professionals.
• (e) cognitive screening and mental health in neurodivergent and underserved populations.

A full list of my publications can be found on Google Scholar, PubMed and ResearchGate. 

Hari I, Adeyemi OF, Gowland P, Bowtell R, Mougin O, Vesey P, Shah J, Mukaetova-Ladinska EB, Hosseini AA. Memory Impairment in Amyloidβ-status Alzheimer's disease is associated with a reduction in CA1 and dentate gyrus volume: in vivo MRI at 7T. Neuroimage. 2024:120607. doi: 10.1016/j.neuroimage.2024.120607

Chithiramohan T, Santhosh S, Threlfall G, Hull L, Mukaetova-Ladinska EB, Subramaniam H, Beishon L Culture-Fair Cognitive Screening Tools for Assessment of Cognitive Impairment: A Systematic Review. J Alzheimers Dis Rep. 2024;8(1):289-306. doi: 10.3233/ADR-230194

Paddick SM, Mukaetova-Ladinska EB. Recent advances in HIV-associated neurocognitive disorders: a focus on older adults and sub-Saharan Africa. Curr Opin Psychiatry. 2024;37(2):87-93. doi: 10.1097/YCO.0000000000000919

Paddick SM, Gamassa E, Mwaluwinga N, Lewis G, Duinmaijer A, Urasa S, Tucker L, Mukaetova-Ladinska EB, Cosker G, Dekker M, Kisoli A, Cletus J, Lissu C, Dotchin C, Gray WK, Walker R. Preliminary evaluation of a smartphone application (DelApp) for identification of delirium in sub-Saharan Africa. Acta Neuropsychiatr. 2023 Jun 22:1-9. doi: 10.1017/neu.2023.29

Dua D, Stubbs O, Urasa S, Rogathe J, Duijinmaijer A, Howlett W, Dekker M, Kisoli A, Mukaetova-Ladinska EB, Gray WK, Lewis T, Walker RW, Dotchin CL, Lwezuala B, Makupa PC, Paddick SM. The prevalence and outcomes of depression in older HIV-positive adults in Northern Tanzania: a longitudinal study.  J Neurovirol. 2023;29(4):425-439. doi: 10.1007/s13365-023-01140-4

Saman Y, Sharif M, Lee A, Ahmed S, Pagán A, McGuirk M, Rea O, Patel R, Bunting F, Spence C, Yoon HJ, Mukaetova-Ladinska E, Rea P, Kheradmand A, Golding J, Arshad Q. Sex-disease dimorphism underpins enhanced motion sickness susceptibility in primary adrenal insufficiency: a cross-sectional observational study. Exp Brain Res. 2023;241(4):1199-1206. doi: 10.1007/s00221-023-06592-y

Mukaetova-Ladinska EB, Liu Y, Venneri A. Editorial: The impact of physical activity on white matter during healthy aging. Front Aging Neurosci. 2023;15:1140767. doi: 10.3389/fnagi.2023.1140767

Crook H, Ramirez A, Hosseini A, Vavougyios G, Lehmann C, Bruchfeld J, Schneider A, D'Avossa G, Lo Re V, Salmoiraghi A, Mukaetova-Ladinska E, Katshu M, Boneschi FM, Håkansson K, Geerlings M, Pracht E, Ruiz A, Jansen JFA, Snyder H, Kivipelto M, Edison P. European Working Group on SARS-CoV-2: Current Understanding, Unknowns, and Recommendations on the Neurological Complications of COVID-19. Brain Connect. 2023;13(4):178-210. doi: 10.1089/brain.2022.0058

Chithiramohan T, Threlfall G, Abdelaziz H, Ellahi A, Subramaniam H, Beishon L, Mukaetova-Ladinska EB. Ethnic Variations in Patient Outcomes in a Memory Clinic Setting Between 2013 and 2021.  J Alzheimers Dis. 2023;92(1):71-79. doi: 10.3233/JAD-220925

Hellis E, Mukaetova-Ladinska EB. Informal Caregiving and Alzheimer's Disease: The Psychological Effect. Medicina (Kaunas). 2022 Dec 27;59(1):48. doi: 10.3390/medicina59010048

Santiago-Mujika E, Luthi-Carter R, Giorgini F, Mukaetova-Ladinska EB. Tubulin Isotypes and Posttranslational Modifications in Vascular Dementia and Alzheimer's Disease. J Alzheimers Dis Rep. 2022 Nov 24;6(1):739-748. doi: 10.3233/ADR-220068

de Erausquin GA, Snyder H, Brugha TS, Seshadri S, Carrillo M, Sagar R, Huang Y, Newton C, Tartaglia C, Teunissen C, Håkanson K, Akinyemi R, Prasad K, D'Avossa G, Gonzalez-Aleman G, Hosseini A, Vavougios GD, Sachdev P, Bankart J, Mors NPO, Lipton R, Katz M, Fox PT, Katshu MZ, Iyengar MS, Weinstein G, Sohrabi HR, Jenkins R, Stein DJ, Hugon J, Mavreas V, Blangero J, Cruchaga C, Krishna M, Wadoo O, Becerra R, Zwir I, Longstreth WT, Kroenenberg G, Edison P, Mukaetova-Ladinska E, Staufenberg E, Figueredo-Aguiar M, Yécora A, Vaca F, Zamponi HP, Re VL, Majid A, Sundarakumar J, Gonzalez HM, Geerlings MI, Skoog I, Salmoiraghi A, Boneschi FM, Patel VN, Santos JM, Arroyo GR, Moreno AC, Felix P, Gallo C, Arai H, Yamada M, Iwatsubo T, Sharma M, Chakraborty N, Ferreccio C, Akena D, Brayne C, Maestre G, Blangero SW, Brusco LI, Siddarth P, Hughes TM, Zuñiga AR, Kambeitz J, Laza AR, Allen N, Panos S, Merrill D, Ibáñez A, Tsuang D, Valishvili N, Shrestha S, Wang S, Padma V, Anstey KJ, Ravindrdanath V, Blennow K, Mullins P, Łojek E, Pria A, Mosley TH, Gowland P, Girard TD, Bowtell R, Vahidy FS. Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium.A lzheimers Dement (N Y). 2022;8(1):e12348. doi: 10.1002/trc2.12348

Wright JR, Deen QFE, Stevenson A, Telford-Cooke LL, Parker C, Martin-Ruiz C, Steinert JR, Kalaria RN, Mukaetova-Ladinska EB. Plasma Myeloperoxidase as a Potential Biomarker of Patient Response to Anti-Dementia Treatment in Alzheimer's Disease.  J Alzheimers Dis. 2022;89(4):1483-1492. doi: 10.3233/JAD-220642

PHOSP-COVID Collaborative Group. Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. Lancet Respir Med. 202210(8):761-775. doi: 10.1016/S2213-2600(22)00127-8

Beishon LC, Haunton VJ, Bradbury-Jones C, Subramaniam H, Mukaetova-Ladinska EB, Panerai RB, Robinson TG, Evley R. The Cognition and Flow Study (CogFlowS): A Mixed Method Evaluation of a Randomized Feasibility Trial of Cognitive Training in Dementia. J Alzheimers Dis. 2022;87(3):1013-1031. doi: 10.3233/JAD-215726

Hosseini AA, Brown T, Mannino L, Gran B, Junaid K, Mukaetova-Ladinska EB. Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia. J Alzheimers Dis. 2022;87(2):771-780. doi: 10.3233/JAD-215650

Mukaetova-Ladinska EB, De Lillo C, Arshad Q, Subramaniam HE, Maltby J. Cognitive Assessment of Dementia: The Need for an Inclusive Design Tool. Curr Alzheimer Res. 2022;19(4):265-273. doi: 10.2174/1567205019666220315092008

Abdullah S, Critchfield M, Maltby J, Mukaetova-Ladinska EB. Improving Diagnosis of Functional Cognitive Impairment in Younger Adults in Primary Care: Validation of Cognitive Screening Tools and the 4-Item Geriatric Depression Scale. J Alzheimers Dis. 2022;86(4):1797-1804. doi: 10.3233/JAD-215552. PMID: 35253757

Raha AA, Biswas A, Henderson J, Chakraborty S, Holland A, Friedland RP, Mukaetova-Ladinska E, Zaman S, Raha-Chowdhury R. Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain: Implication for Protein Aggregation in Down Syndrome Dementia, Alzheimer's, and Parkinson's Diseases.  Int J Mol Sci. 2022;23(3):1060. doi: 10.3390/ijms23031060

Spooner R, Ranasinghe S, Urasa S, Yoseph M, Koipapi S, Mukaetova-Ladinska EB, Lewis T, Howlett W, Dekker M, Kisoli A, Gray WK, Walker RW, Dotchin CL, Kalaria R, Lwezuala B, Makupa PC, Akinyemi R, Paddick SM. HIV-Associated Neurocognitive Disorders: The First Longitudinal Follow-Up of a cART-Treated Cohort of Older People in Sub-Saharan Africa. J Acquir Immune Defic Syndr. 2022;90(2):214-222. doi: 10.1097/QAI.0000000000002934

Mukaetova-Ladinska EB, Abdullah S, Critchfield M, Maltby J. Suspected Dementia in Young Adults: Cognitive Screening Tools for Use in Primary Care. J Alzheimers Dis. 2022;86(1):333-341. doi: 10.3233/JAD-215514

Chithiramohan T, Parekh JN, Kronenberg G, Haunton VJ, Minhas JS, Panerai RB, Robinson TG, Divall P, Subramaniam H, Mukaetova-Ladinska E, Beishon L. Investigating the association between depression and cerebral haemodynamics-A systematic review and meta-analysis. J Affect Disord. 2022;299:144-158. doi: 10.1016/j.jad.2021.11.037

Applicants for PhD, Doctorate in Psychology and Master and intercalated medical students most welcome. 

At present I supervise a number of PhD and doctorate students working on raising awareness of mental health among people from ethnic background, developing cognitive tests for use in underserved populations and dementia issues among people from ethnic background.

Topics

• Cognition/dementia and mental health in older people
• Early onset dementia
• Biomarkers for dementia

• Medical and psychology undergraduate students
• MRes in Biology of Ageing, Newcastle University
• Internal and external undergraduate and postgraduate examiner

• Mental health and cognition/dementia in older people and people from ethnic background
• Young onset dementia
• Mental health and dementia and COVID-19

• Associated Editor Frontiers Ageing Neuroscience
• Associated Editor Frontiers Psychiatry (Old Age Psychiatry)
• Visiting Professor, School of Clinical Psychology, UACS Skopje
• Reviewer for a number of neurology, old age psychiatry and neuroscience Journals and Research Bodies
• External examiner University of Tasmania (Australia), University of Coimbra (Portugal), Sts Cyril and Methodius and UACS Skopje (N Macedonia), Institute of Psychiatry, Psychology and Neuroscience (IoPPN) at King's College (London), University of Oxford, Newcastle University, University of Birmingham, University of Edinburgh (UK)
• External examiner for Neuroscience Postgraduate module University of Southampton
• External examiner for Medicine, University of Nottingham
• Member of WHO Neurology COVID-19 working group
• Member of Alzheimer's Association Global Consortium on CNS SARS CoV-2

• MD (Ss Cyril and Methodius University, Skopje, N Macedonia)
• MMedSci in Clinical Psychiatry (Ss Cyril and Methodius University, Skopje, N Macedonia)
• PhD (University of Cambridge, UK)
• FRCPsych (London, UK)