People

Dr Elaine Browne

Lecturer Lead for Phase 1 Assessment

Profile

I am a geneticist/cell biologist who has worked in undergraduate medical education since 2016. Before that I was a research fellow in the School of Medicine University of St Andrews where I worked on a number of different research projects.

I joined Leicester Medical School in September 2020 and am currently the lead for Phase I Assessment. 

Research

I am particularly interested in the MHC class I molecule HLA-B27 and the role it plays in the inflammatory arthritis ankylosing spondylitis.

Publications

(0) Guiliano DB, North H, Panayoitou E, Campbell EC, McHugh K, Cooke FG, Silvestre M, Bowness P, Powis SJ, Antoniou AN. Polymorphsms in the F pocket of HLA-B27 strongly impact on assembly, chaperone interaction and heavy chain misfolding. Arthritis and Rheumatology 69(3):610-621 doi: 10.1002/art.39948.

Guiliano, D.B., Fussell, H., Lenart, I., Tsao, E., Nesbeth, D., Fletcher, A.J., Campbell, E.C., Yousaf, N., Williams, S., Santos, S., Cameron, A., Towers, G.J., Kellam, P., Hebert, D.N., Gould, K.G., Powis, S.J. and Antoniou, A.N. Endoplasmic reticulum degradation-enhancing a-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endplasmic reticulum-associated degradation. Arthritis & Rheumatology 66(11):2976-88. doi: 10.1002/art.38809.

Riches, A.C., Campbell, E.C., Borger, E. and Powis, S.J. Regulation of exosome release from mammary epithelial and breast cancer cells - a new regulatory pathway. European Journal of Cancer 50(5):1025-34. doi: 10.1016/j.ejca.2013.12.019. [Epub 2014 Jan 22].

Zheng, Y., Campbell, E.C., Lucocq, J., Riches, A. and Powis, S.J. Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis. Experimental Cell Research 319(12):1706-13. doi: 10.1016/j.yexcr.2012.10.006. [Epub 2012 Oct 22].

Campbell, E.C., Antoniou, A.N. and Powis, S.J. (2012) The multi-faceted nature of HLA class I dimer molecules. Immunology 136(4): 380-4.

Soo, C.Y., Song, Y., Zheng, Y., Campbell, E.C., Riches, A.C., Gunn-Moore, F. and Powis, S.J. (2012) Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells. Immunology 136: 192-7.

Makhadiyeva, D., Lam, L., Moatari, M., Vallance, J., Zheng, Y., Campbell, E.C. and Powis, S.J. (2012) MHC class I dimer formation by alteration of the cellular redox environment and induction of apoptosis. Immunology 135: 133-9.

Lenart, I., Guiliano, D.B., Burn, G., Campbell, E.C., Morley, K., Fussell, H., Powis, S.J. and Antoniou, A.N. (2012) The MHC class I heavy chain structurally conserved cysteines 101 and 164 participate in HLA-B27 dimer formation. Antioxidants and Redox Signalling 16: 33-43.

Campbell, E.C., Fettke, F., Bhat, S., Morley, K. and Powis, S.J. (2011) Expression of MHC class I dimers and ERAP1 in an ankylosing spondylitis patient cohort. Immunology 133: 379-385.

Powis, S.J., Soo, C.Y., Zheng, Z., Campbell, E.C. and Riches, A. (2011) Nanoparticle tracking analysis of cell exosome and nanovesicle secretion. Microscopy and Analysis 25: 7-9.

Supervision

I am a personal tutor within Leicester Medical School

Teaching

I am Lead for Phase 1 Assessment at Leicester Medical School.

Activities

Fellow of HEA
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