Dr Elaine Browne

I am a geneticist/cell biologist who has worked in undergraduate medical education since 2016. Before that I was a research fellow in the School of Medicine University of St Andrews where I worked on a number of different research projects.

I joined Leicester Medical School in September 2020 and am currently the lead for Phase I Assessment. 

(0) Guiliano DB, North H, Panayoitou E, Campbell EC, McHugh K, Cooke FG, Silvestre M, Bowness P, Powis SJ, Antoniou AN. Polymorphsms in the F pocket of HLA-B27 strongly impact on assembly, chaperone interaction and heavy chain misfolding. Arthritis and Rheumatology 69(3):610-621 doi: 10.1002/art.39948.

Guiliano, D.B., Fussell, H., Lenart, I., Tsao, E., Nesbeth, D., Fletcher, A.J., Campbell, E.C., Yousaf, N., Williams, S., Santos, S., Cameron, A., Towers, G.J., Kellam, P., Hebert, D.N., Gould, K.G., Powis, S.J. and Antoniou, A.N. Endoplasmic reticulum degradation-enhancing a-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endplasmic reticulum-associated degradation. Arthritis & Rheumatology 66(11):2976-88. doi: 10.1002/art.38809.

Riches, A.C., Campbell, E.C., Borger, E. and Powis, S.J. Regulation of exosome release from mammary epithelial and breast cancer cells - a new regulatory pathway. European Journal of Cancer 50(5):1025-34. doi: 10.1016/j.ejca.2013.12.019. [Epub 2014 Jan 22].

Zheng, Y., Campbell, E.C., Lucocq, J., Riches, A. and Powis, S.J. Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis. Experimental Cell Research 319(12):1706-13. doi: 10.1016/j.yexcr.2012.10.006. [Epub 2012 Oct 22].

Campbell, E.C., Antoniou, A.N. and Powis, S.J. (2012) The multi-faceted nature of HLA class I dimer molecules. Immunology 136(4): 380-4.

Soo, C.Y., Song, Y., Zheng, Y., Campbell, E.C., Riches, A.C., Gunn-Moore, F. and Powis, S.J. (2012) Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells. Immunology 136: 192-7.

Makhadiyeva, D., Lam, L., Moatari, M., Vallance, J., Zheng, Y., Campbell, E.C. and Powis, S.J. (2012) MHC class I dimer formation by alteration of the cellular redox environment and induction of apoptosis. Immunology 135: 133-9.

Lenart, I., Guiliano, D.B., Burn, G., Campbell, E.C., Morley, K., Fussell, H., Powis, S.J. and Antoniou, A.N. (2012) The MHC class I heavy chain structurally conserved cysteines 101 and 164 participate in HLA-B27 dimer formation. Antioxidants and Redox Signalling 16: 33-43.

Campbell, E.C., Fettke, F., Bhat, S., Morley, K. and Powis, S.J. (2011) Expression of MHC class I dimers and ERAP1 in an ankylosing spondylitis patient cohort. Immunology 133: 379-385.

Powis, S.J., Soo, C.Y., Zheng, Z., Campbell, E.C. and Riches, A. (2011) Nanoparticle tracking analysis of cell exosome and nanovesicle secretion. Microscopy and Analysis 25: 7-9.