Dr David McVey

I studied genetics at the University of Leicester before completing my PhD in cardiovascular sciences, also at the University of Leicester, which involved the use of genome editing to examine the effects of coronary artery disease-associated genetic variants. My subsequent post-doctoral work at the University of Leicester has continued to investigate the role and interplay of genetic variants, gene expression and cell behaviour to improve our understanding of cardiovascular disease.

My research interests focus on the genetics of coronary artery disease and other cardiovascular diseases. My current work explores the role of genetic variants in the regulation of vascular cell function and how these variants influence both gene expression and cell behaviour in response to inflammatory signalling to further our understanding of the interaction between inflammation, the genome and cell function in cardiovascular disease. My research also explores the use of novel technologies for the generation of high-throughput gene expression data from large sample cohorts.

Jiang, M., Song, Y., Ren, M.X., He, R.C., Dong, X.H., Li, X.H., Lu, Z.F., Li, S., Wu, J., Bei, Y.R., Liu, F., Long, Y., Wu, S.G., Liu, X.H., Wu, L.M., Yang, H.L., McVey, D.G., Dai, X.Y., Ye, S. and Hu, Y.W. 2023. LncRNA NIPA1-SO confers atherosclerotic protection by suppressing the transmembrane protein NIPA1. Journal of Advanced Research. Online ahead of print.

Solomon*, C.U., McVey*, D.G., Andreadi*, C., Gong*, P., Turner*, L., Stanczyk*, P.J., Khemiri, S., Chamberlain, J.C., Yang, W., Webb, T.R., Nelson, C.P., Samani, N.J. and Ye, S. 2022. Effects of Coronary Artery Disease-Associated Variants on Vascular Smooth Muscle Cells. Circulation 146(12), 917-929. *these authors contributed equally

Karamanavi, E., McVey, D.G., van der Laan, S.W., Stanczyk P.J., Morris, G.E., Wang, Y., Yang, W., Chan, K., Poston, R.N., Luo, J., Zhou, X., Gong, P., Jones, P.D., Cao, J., Kostogrys, R.B., Webb, T.R., Pasterkamp, G., Yu, H., Xiao, Q., Greer, P.A., Stringer, E.J., Samani, N.J. and Ye, S. 2022. The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis. Circulation Research 131(12), 1004-1017.

Yousuf, A., McVey, D.G. and Ye, S. 2022. Relationship between red meat metabolite trimethylamine N-oxide and cardiovascular disease. Heart and Mind 6(1), 3-9.

Bird, M.F., Gallacher-Horley, B., McDonald, J., McVey, D.G., Al-Janabi, F., Guerrini, R., Calo, G., Ye, S., Thompson, J.P. and Lambert, D.G. 2022. In vitro sepsis induces Nociceptin/Orphanin FQ receptor (NOP) expression in primary human vascular endothelial but not smooth muscle cells. PLoS One 17(9), e0274080.

Giakomidi, D., Khemiri, S., Mahbuba, W., McVey, D.G., Al-Janabi, F., Guerrini, R., Calo, G., Ye, S., Lambert, D.G. 2022. Nociceptin/Orphanin FQ receptor expression in primary human umbilical vein endothelial cells is not regulated by exposure to breast cancer cell media or angiogenic stimuli. BJA Open 4 (C): 100110.

Yang, X., Yang, W., McVey, D.G., Zhao, G., Hu, J., Poston, R.N., Ren, M., Willeit, K., Coassin, S., Willeit, J., Webb, T.R., Samani, N.J., Mayr, M., Kiechl, S. and Ye, S. 2020. FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease-Associated Genetic Variant and Influences Monocyte Transendothelial Migration. Journal of the American Heart Association 9(4), e014333

Hu, Y,W,, Guo, F.X., Xu, Y.J., Li, P., Lu, Z.F., McVey, D.G., Zheng, L., Wang, Q., Ye, J.H., Kang, C.M., Wu, S.G., Zhao, J.J., Ma, X., Yang, Z., Fang, F.C., Qiu, Y.R., Xu, B.M., Xiao, L., Wu, Q., Wu, L.M., Ding, L., Webb, T.R., Samani, N.J. and Ye, S. 2019. Long noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN. Journal of Clinical Investigation 129(3), 1115-1128.

Zhao, G., Yang, W., Wu, J., Chen, B., Yang, X., Chen, J., McVey, D.G., Andreadi, C., Gong, P., Webb, T.R., Samani, N.J. and Ye, S. 2018. Influence of a Coronary Artery Disease-Associated Genetic Variant on FURIN Expression and Effect of Furin on Macrophage Behavior. Arteriosclerosis, Thrombosis and Vascular Biology 38(8), 1837-1844.

Jones P.D., Kaiser, M.A., Ghaderi Najafabadi, M., McVey, D.G., Beveridge, A.J., Schofield, C.L., Samani, N.J. and Webb, T.R. 2016. The Coronary Artery Disease-associated Coding Variant in Zinc Finger C3HC-type Containing 1 (ZC3HC1) Affects Cell Cycle Regulation. Journal of Biological Chemistry 291(31), 16318-16327.

Veal, C.D., Xu, H., Reekie, K., Free, R., Hardwick, R.J., McVey, D., Brookes, A.J., Hollox, E.J., and Talbot, C.J. 2013. Automated Design of Paralogue Ratio Test Assays for the Accurate and Rapid Typing of Copy Number Variation, Bioinformatics 29(16), 1997-2003.

I currently supervise the laboratory activities of undergraduate, postgraduate and doctoral students during their research projects, providing training and guidance on a variety of molecular biology and cell culture techniques.

• BSc (Hons): Biological Sciences - Genetics (Leicester, 2011)
• PhD: Cardiovascular Sciences (Leicester, 2015)