People

Dr Beatriz Guillen Guio

Postdoctoral Research Fellow

School/Department: Health Sciences, Department of

Email: bgg4@leicester.ac.uk

Profile

I am a Biotechnologist from the University of Salamanca (Spain) and I undertook my PhD in Health Sciences at the University Hospital Nuestra Senora de Candelaria (Spain). Here I studied the genetics of acute respiratory distress syndrome (ARDS) and variations in the microbiome of patients through genomic and metagenomic approaches. I have also been involved in research projects focused on the genetics of other complex respiratory diseases, including idiopathic pulmonary fibrosis and asthma.

I joined the Genetic Epidemiology research group in April 2021 as a Postdoctoral Fellow to further develop my research in the field of ARDS and pulmonary fibrosis genetics. 


Research

Genetic and environmental factors influence COVID-19 susceptibility and outcomes, including the development of acute respiratory distress syndrome (ARDS), characterized by pulmonary infiltrates and severe hypoxaemia, and short- and long-term pulmonary fibrosis (i.e., lung scarring). These lung pathologies have a high mortality and there are no specific treatment options or effective prognostic methods for patients.

I currently hold a Sir Henry Wellcome Postdoctoral Fellowship to perform a genomic epidemiology study of ARDS and pulmonary fibrosis in patients with COVID-19. The main aims of this study are 1) to identify novel genes and biological pathways that may represent new therapeutic targets leading to development of new drugs and 2) to develop risk prediction models, which could enhance patient stratification for those at increased risk of lung sequela.

Publications

(0)

Allen RJ*, Guillen-Guio B*, et al. Genetic overlap between idiopathic pulmonary fibrosis and COVID-19 (2022). Eur Respir J, In Press. *equal contribution as first authors.

Allen RJ, Stockwell A, Justin M Oldham JM, Guillen-Guio B, et al. Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis (2022). Thorax, In Press.

Suarez-Pajes E,..., Guillen-Guio B. Targeted analysis of genomic regions enriched in African ancestry reveals novel classical HLA alleles associated with asthma in Southwestern Europeans (2021). Sci Rep, 11:23686.

Hernandez-Beeftink T, Guillen-Guio B, et al. Whole-Blood Mitochondrial DNA Copies Are Associated With the Prognosis of Acute Respiratory Distress Syndrome After Sepsis (2021). Front Immunol, 12:737369

Suarez-Pajes E, Diaz-de Usera A, Marcelino-Rodri­guez I, Guillen-Guio B*, Flores C*. Genetic Ancestry Inference and Its Application for the Genetic Mapping of Human Diseases (2021). Int J Mol Sci, 22:6962. *equal contribution as senior authors.

Sepsis Lung Microbiome Study Group (Guillen-Guio B, et al). Could lung bacterial dysbiosis predict ICU mortality in patients with extra-pulmonary sepsis? A proof-of-concept study (2020). Intensive Care Med, 46:2118-2120.

Guillen-Guio B, et al. Admixture mapping of asthma in southwestern Europeans with North African ancestry influences (2020). Am J Physiol Lung Cell Mol Physiol, 318:L965-L975.

Guillen-Guio B, et al. Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study (2020). Lancet Respir Med, 8:258-266.

Allen RJ, Guillen-Guio B, et al. Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis (2020). Am J Respir Crit Care Med, 201:564-574.

Hernandez-Beeftink T, Guillen-Guio B, Villar J, Flores C. Genomics and the Acute Respiratory Distress Syndrome: Current and Future Directions (2019). Int J Mol Sci, 20:16.

Lorenzo-Salazar JM, Ma SF, Jou J, Hou PC, Guillen-Guio B, et al. Novel idiopathic pulmonary fibrosis susceptibility variants revealed by deep sequencing (2019). ERJ Open Res, 5:00071-2019

Mendoza-Alvarez A, Guillen-Guio B, et al. Whole-exome sequencing identifies somatic mutations associated with mortality in metastatic clear cell kidney carcinoma (2019). Front Genet, 10:439.

Guillen-Guio B, et al. Genomic analyses at the South-western edge of human European diversity: isolation, African influence and disease links in the Canary Islands (2018). Mol Biol Evol, 35:3010-3026.

Allen RJ, Porte J, Braybrooke R, Flores C, Fingerlin TE, Oldham JM, Guillen-Guio B, et al. Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study (2017). Lancet Respir Med, 5:869-880.

Flores C, Guillen-Guio B. Genomic Insights Into Sepsis Course Using Whole Exome Sequencing (2016). EBioMedicine, 12:18-19.

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Supervision

Genetic variation in complex respiratory diseases

Teaching

-

Press and media

Genetics and genomics of acute respiratory distress syndrome and pulmonary fibrosis
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