New research can help policymakers prioritise funding needs and allocate resource for cancer
Results from the largest ever review of clinical trials in cancer screening, prevention, and early detection (SPED) have been published.
The review, published in BMC Cancer and funded by the National Cancer Research Institute, found that 61% of all SPED trials focused on just three cancer types – colorectal, breast, and cervical cancer. This compares with 6.4% in lung cancer and 1.8% in liver cancer, which are responsible for 26.3% of global cancer deaths compared with 19.3% for colorectal, breast, and cervical cancer.
Researchers identified areas of unmet needs around the world to highlight where more research and funding is needed. 88% of all SPED trials were conducted in North America, Europe, or Asia, with a lack of trials conducted in Africa and South America and a very low number of trials per head of population in Asia.
Results also highlighted that significant disparities exist between the proportion of SPED trials for certain cancer types and their global burden of disease. For example, colorectal cancer accounted for 32.9% of all SPED trials and 9.4% of global cancer deaths, whilst gastric cancers accounted for 1.5% of SPED trials and 7.7% of global cancer deaths.
This study was led by researchers at the universities of Nottingham and Manchester, and involved researchers from the University of Leicester, Leicester National Institute for Health and Care Research (NIHR) along with other Higher Education institutes across England and Scotland.Dr Emma O’Dowd, Consultant Respiratory Physician and Associate Professor at the University of Nottingham, says: “Cancer is the most common cause of death and disability in the UK and the second most common cause globally. Global annual cancer incidence is forecast to rise to 27.5 million by 2040, a 62% increase from 2018. For most cancers, prevention and early detection are the most effective ways of reducing mortality.
“We looked at all trials published between 2007 and 2020 covering cancer screening, prevention, and early diagnosis to map what research had been done by cancer type, trial focus and geographical area, and to highlight research gaps.
“Over 117,000 papers were identified, and 2,888 trials were included. There were disparities in terms of geographical location, type of research conducted and a clear focus on a small number of cancer types. We hope that this important piece of work can be used to guide and prioritise future trial funding.”Dr Samuel Merriel, GP and NIHR Academic Clinical Lecturer at the University of Manchester, added: “There are finite resources that governments can allocate for cancer healthcare and a limited amount of money available for cancer research. Until now there has not been a detailed summary of all the studies of cancer prevention, cancer screening, and earlier detection of cancer.
“We hope that these findings and the database of studies we have generated can be used by policymakers, healthcare commissioners, and cancer research funders to address the disparities in cancer screening, prevention, and early diagnosis trials.”
Dr Lynne Howells, operations manager for the University of Leicester’s Institute for Precision Health, said: “Cancer screening, prevention and early detection (SPED) is a key focus for Leicester’s Cancer Research Centre and NIHR Biomedical Research Centre supported by the Institute for Precision Health. This work will help to identify priority SPED areas for researchers, funders and policy-makers alike, providing opportunity to more effectively target resource.”
Dr Sameena Khan, NIHR academic clinical lecturer in oncology at the University of Leicester added: “This work arose from the National Cancer Research Institute SPED group as a trainee project. It demonstrates how early career researchers are able to effectively network and work collaboratively across multiple centres to deliver high quality, largescale meaningful outputs. This mapping review was a huge undertaking, and the Leicester team is proud to have made a significant contribution in highlighting the global landscape and challenges in cancer screening, prevention and early detection.”