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Global study identifies a safer treatment of acute stroke

The safety of a controversial clot-busting drug has been investigated by researchers, who have shown a modified dosage can reduce serious bleeding in the brain and improve survival rates.

It is hoped the findings from the trial of more than 3,000 patients in 100 hospitals worldwide could change the way the most common form of stroke is treated globally.

Intravenous rtPA (or alteplase) is given to people suffering acute ischaemic stroke and works by breaking up clots blocking the flow of blood to the brain. However, it can cause serious bleeding in the brain in around five per cent of cases, with many of these proving fatal.

The study was conducted by teams at the George Institute for Global Health and the Department of Cardiovascular Sciences.

National Coordinator of the study in the UK, Professor Tom Robinson of the University said: “This trial was a randomised controlled trial, which is the gold standard for determining whether a medicine actually has the desired effect.

“The results provide important information when discussing clot-busting treatment with patients and their families. Most patients who have a major stroke want to know they will survive but without being seriously dependent on their family. We have shown this to be the case with the lower dose of the drug. Stroke is the fourth leading cause of death in the UK and the leading cause of adult neurological disability. There are over 150,000 strokes each year in the UK, one in four of whom are in people of working age. Currently, approximately 11 per cent of stroke patients receive thrombolysis treatment for stroke in the UK.”

These differing effects meant that the trial was unable to show conclusively that the low dose was as effective as standard dose rtPA in terms of survivors being free of any disability.

rtPA is used to dissolve clots that block a blood vessel in a patient’s brain within the first few hours after the onset of stroke symptoms. Yet, because many people with stroke arrive at hospital after this crucial time window, only around five per cent of eligible people currently receive this therapy in most countries.

Concerns over the risks of bleeding on the brain associated with rtPA have prompted independent reviews of the research evidence in Australia and the UK.

An interview with Professor Robinson is available below:

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