Biochemistry 3: Cellular Regulation of Energy and Metabolism
Module code: BS2093
Module co-ordinators: Dr Ralf Schmid and Dr Salvador Macip
In this module you will study how cells generate and use energy. You will also look at the general aspects of enzyme kinetics and regulation, and explore how selected aspects of lipid and carbohydrate metabolism are regulated in normal cells and disease states.
We will study the pathways involved in the catabolism of dietary carbohydrates and lipids and look at how metabolism is regulated as a consequence of metabolic demand. We will also investigate how defects in metabolic control mechanisms can lead to disease states, together with the special metabolic requirements of a cancer cell and how these determine tumour progression. We will look at the properties of enzymes and the different ways protein activity is regulated. You will also learn about the molecular mechanisms involved in energy transduction as shown by proteins involved in movement, electron transport, and ATP synthesis.Topics covered
- Selected aspects of carbohydrate metabolism
- Aspects of lipid metabolism
- Oxidative phosphorylation and ATP synthesis
- Cancer metabolism
- Properties of enzymes, enzyme kinetics and regulation
- Energy use in motility and transport
Learning
- 27 one-hour lectures
- 12 hours of practicals
- 2 one-hour tutorials
Assessment
- Exam, 3 hours (70%)
- Practical write-up (10%)
- Computer-based activities and tutorial work, including presentation (20%)