Genetic Epidemiology



EXCEED (Extended Cohort for E-health, Environment and DNA) looks at the causes of long-term health conditions by collecting information about genes and lifestyle. More than 10,000 people have already taken part.

We now aim to understand why some people develop more severe COVID-19 than others, and the impact of the pandemic on long-term conditions. This will help develop new ways to prevent or treat COVID-19 and long-term conditions during and after the pandemic. Minority ethnic and migrant communities have had higher rates of COVID-19 hospital admissions. To understand why this is happening we especially encourage volunteers to join us from these communities.


  • PHOSP-COVID: Post-HOSPitalisation COVID-19 study – a national consortium to understand and improve long-term health outcomes
  • Chief Investigator: Professor Chris Brightling
  • Study start date: July 2020

PHOSP-COVID is the first UK wide study to assess the impact of COVID-19 on patient health and their recovery.

As we emerge from the first wave of the COVID-19 pandemic, we have new insights into the acute phase of this disease but very little information concerning long-term effects of COVID-19 and the ongoing medical, psychological and rehabilitation needs of these patients. For those who were hospitalised and have since been discharged, it is not yet clear what the health needs for people diagnosed with COVID-19 will be to enable them to make as full a recovery as possible.

To address this gap in our understanding, an 18-month research study aims to understand:

  • Why some people recover more quickly than others
  • Why some patients develop other health problems later on
  • Which treatments received in hospital or afterwards were helpful
  • How we can improve care of patients after they have been discharged from hospital

The PHOSP-COVID study will draw on expertise from a national consortium of leading researchers and clinicians – involving 20 universities and associated NHS trusts. Assessments of patients using techniques such as advanced imaging, data collection and analysis of blood will be undertaken, creating a more comprehensive picture of the impact of COVID-19 on longer term health outcomes across the UK.


UK-REACH will provide novel evidence on COVID-19 outcomes among ethnic minority healthcare workers to inform the development of risk reduction and support programmes through increased understanding of risk as well physical and mental health outcomes. Ultimately, this will reduce health inequalities and improve the long term health outcomes of healthcare workers.

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