The chemical biology theme draws together researchers from medicinal chemistry, synthetic organic and inorganic chemistry, and biophysics. Using combined expertise in synthesis and physical measurement, we are pursuing projects aimed at understanding the interactions between macromolecules in complexes, and how molecules in biology carry out their many diverse activities. By exploiting the underlying chemistry of biological processes, we are able to manipulate macromolecular function and activity facilitating translational research for drug development. We have broad expertise in the development of chemical probes and compound libraries, and the application of frontier techniques in spectroelectrochemistry and single molecule spectroscopy.