The impact and structural correlates of glare in infantile nystagmus

Qualification: PhD

Department: Neuroscience Psychology and Behaviour

Application deadline: 18 October 2021

Start date: January 2022

Overview

Supevisors:

Project description:

Glare leads to discomfort and impaired vision and can severely affect activities of daily living. The impact of glare on reading has been poorly investigated. Abnormalities of the iris, such as iris malformations and iris translucency (called iris transillumination) specifically lead to glare. Hence pigmentation disorders associated with albinism are one of the most common causes of glare disorders. People with albinism also commonly have infantile nystagmus (IN), involuntary oscillations of the eyes. The Ulverscroft Eye Unit research team in Leicester has been at the forefront of measuring eye movements in people with albinism and nystagmus as well as imaging the 3-dimensional structure of the eyes using a technique called optical coherence tomography (OCT). OCT can be used to generate high resolution cross-sectional images of the iris.

The overarching aim of this project is to understand the impact of glare on people with albinism and other types of IN, especially on the ability to read. We also aim to optimise the measurement of glare and explore strategies to alleviate glare. Consequently, the PhD will be in the area of clinical vision and will involve gaining expertise in a number of techniques including glare assessment measurement tools; imaging of the eyes using OCT especially in the measurement of iris structure; eye movement recording techniques using pupil video-oculography; clinical visual assessment and statistical techniques.

The student will join a strong research unit in the Ulverscroft Eye Unit with an international reputation for research into nystagmus, paediatric ophthalmology and imaging of the eye as evidenced by our strong publication track record. Within the department there are a multiplicity of facilities including adult and children’s optical coherence tomography imaging equipment; adult and children’s eye movement recording equipment, posturography equipment, clinical vision testing facilities, and wet labs for collecting genetic samples. We also carry out clinical trials for developmental eye diseases such as nystagmus and amblyopia. Several of our studies assessing functional vision in nystagmus looking at the impact of the disease on postural control, facial recognition and depth perception. These include the largest body of work into the effect of infantile nystagmus on reading.

The Ulverscroft Eye Unit is placed in the Vision Sciences research group within the department of Neuroscience, Psychology and Behaviour. Researchers in the Vision Sciences strand provide additional facilities and support offering expertise in reading research, as well as broader expertise in neuroscientific and visual psychophysical methods for investigating vision. We have an excellent track-record of supporting students and enabling career progression within our unit supported by the wider university. The data generated from this project will provide the basis for the student to explore post-doctoral fellowship funding opportunities to further progress this research.

As one of the UK's top research universities, the University of Leicester has an international reputation for world-leading research. The doctoral college in the University has an expansive researcher development programmes which will give you the skills you need to become an effective researcher, successfully complete your degree and take your expertise into a career beyond your PhD.

Leicester is lively, culturally diverse and easy to enjoy on a budget. The city was named the third most affordable place to live for students by NatWest in 2018, and was named most affordable place to live for students by HSBC in 2014 and 2015. Leicester has been named as one of the best cities in which to live and work for the third year in a row. 

The 2019 Good Growth for Cities Index – released November 2019  – ranks Leicester in the top 10 best places for quality of life, ahead of London and neighbouring Nottingham and Derby. We’re also a happy bunch here in Leicester! According to 9NINE Super Seed, Leicester is UK's 2nd happiest city. The city is packed with a vibrant range of events for you to enjoy, attractions for you to explore, sports and new places to discover.

References:

Prakash E…Proudlock FA. Reading Individual Words Within Sentences in Infantile Nystagmus. 2019. Invest Ophthalmol Vis Sci. 60(6):2226.

Sheth V…Proudlock FA. Diagnostic potential of iris cross-sectional imaging in albinism using optical coherence tomography. 2013. Ophthalmology. 120(10):2082.

Rufai SR…Proudlock FA, Gottlob I. Can Structural Grading of Foveal Hypoplasia Predict Future Vision in Infantile Nystagmus?: A Longitudinal Study. 2020. Ophthalmology. 127(4):492.

Patel A…Proudlock FA. Optic Nerve Head Development in Healthy Infants and Children Using Handheld Spectral-Domain Optical Coherence Tomography. 2016. Ophthalmology. 123(10):2147.

Barot N…Proudlock FA. Reading performance in infantile nystagmus. 2013 Ophthalmology. 120(6):1232.

 

 

 

 

Funding

Funding

This 3-year Fight for Sight Studentship provides:

  • UK/EU tuition fee waiver
  • Annual stipend of £18,000

Entry requirements

Entry requirements

Applicants are required to hold/or expect to obtain a UK Bachelor's Degree 2:1 or better (or overseas equivalent) in a relevant subject e.g. vision or clinical subjects such as orthoptics, optometry or medicine; alternatively neuroscience, biological sciences or psychology.  

The University of Leicester English language requirements apply where applicable.

 

Informal enquiries

Informal enquiries

Project enquiries:

Application enquiries:

How to apply

How to apply

To submit your application, please use the 'Apply' button below and select January 2022 from the dropdown menu.

With your application please include:

  • CV
  • Personal statement explaining your interest in the project, your experience and why we should consider you
  • Degree Certificates and Transcripts of study already completed and if possible transcript to date of study currently being undertaken
  • Evidence of English language proficiency if applicable
  • In the reference section please enter the contact details of your two academic referees in the boxes provided or upload letters of reference if already available
  • In the funding section please specify that you wish to be considered for the Fight for Sight Studentship 
  • In the research proposal section please provide the names of the supervisors and project title (a research proposal is not required)

 

 

Eligibility

Eligibility

UK/EU applicants only