Role of diabetes and ethnicity in the epidemiology of cardiovascular transition from atherothrombotic diseases to heart failure

Qualification: PhD

Department: Health Sciences

Application deadline: 24th August 2020

Start date: 28th September 2020

Overview

Supervisor

Dr Francesco Zaccardi 

Project Description:

Large, multinational epidemiological studies have consistently demonstrated an increased risk of cardiovascular disease in people with diabetes. Most of these studies, however, are based on old cohorts and did not investigate in detail phenotypes of participants and cardiovascular events. These limitations are relevant as: (1) the treatment of diabetes has substantially changed in the last decade; (2) the risk of diabetes and its complications is higher in some ethnic groups (i.e., south Asians); (3) there is some evidence that, within the broad definition of cardiovascular events, there are heterogeneous conditions which could be differently related to diabetes. As such, there is a possibility that other cardiovascular phenotypes are increasingly contributing to the risk of cardiovascular death in people with diabetes, particularly in some ethnic groups. 

This PhD project will undertake a series of epidemiological analyses on datasets available nationally, such as the UK Biobank and the Clinical Practice Research Datalink (CPRD; one of the largest longitudinal databases of anonymised primary care records in the world), to investigate the extent to which these epidemiological transitions are related to the presence of diabetes. In particular, the post holder will work to identify key patterns of mortality trends for different cardiovascular phenotypes (i.e., heart failure and coronary heart disease), in relation to diabetes, ethnicity, and other related factors (i.e., body composition). The student will be embedded within a team of experts in epidemiology of diabetes, cardiovascular disease and heart failure and in big data analysis; the student will receive training in a broad range of statistical techniques, from demographic epidemiology to most-recent survival analysis methods.

The PhD project will be integrated into a vibrant postgraduate research community within the Diabetes Research Centre and Real World Evidence Unit, University of Leicester and help advance the aims of the National Institute of Health Research Leicester Biomedical Research Centre (BRU) and East Midlands Collaboration for Leadership in Applied Health Research and Care (EM-CLAHRC).

 

Funding

Funding

This 3-year CLAHRC East Midland Studentship provides:

  • UK/EU tuition fee waiver
  • Annual Stipend at UKRI rates (£15,285 for 2020/21)
  • Research Training Support Grant (including travel allowance) of £2,500 per annum 

Entry requirements

Entry requirements

UK Bachelor Degree with at least 2:1 in a relevant subject or overseas equivalent.

University of Leicester English language requirements apply (where applicable).

Informal enquiries

Informal enquiries

Project enquiries:

Dr Francesco Zaccardi fz43@leicester.ac.uk 

Application enquiries:

pgradmissions@leicester.ac.uk

How to apply

How to apply

To apply, please use the 'Apply' button at the bottom of the page.

Select 'September 2020' as the start date.

In the funding section of the application please indicate you wish to be considered for the CLAHRC East Midlands 2020 Studentship.

In the proposal section please provide the name of the supervisors and project title (a proposal is not required).

With the application, please include: 

  • CV
  • Personal statement explaining your interest in the project and why we should consider you together with all other relevant application documents. 
  • Degree Certificates and Transcripts of study already completed and if possible transcript to date of study currently being undertaken 
  • Evidence of English language proficiency if applicable
  • In the reference section please enter the contact details of your referees in the boxes provided or upload letters of reference if already available

Eligibility

Eligibility

UK/EU applicants only