Obesity and health: what can primary care data tell us?
Department: Population Health Sciences
Application deadline: 31 March 2023
Start date: 25 September 2023
Obesity, measured by body mass index (BMI), is a fundamental determinant of health and a leading cause of morbidity and premature mortality globally. The importance of obesity to health has been further unmasked by the COVID-19 pandemic, where it has emerged as one of the most consistent and strongest predictors of disease severity and survival. Understanding the impact of obesity on health has largely been driven by relatively small national surveys or research cohorts. However, recent developments with data governance and linkage have provided a step-change in the type and amount of data available. Specifically, linkage between primary and secondary care clinical records with mortality records and other data assets, such as UK Census data, enable common clinical risk factors to be examined on a population level. Early examination of this data by the supervision team reported marked ethnic differences in the association of primary care coded BMI with health outcomes , suggesting BMI may act as an important determinant of health inequality within ethnic minority groups.
The aim of this PhD is to undertake a comprehensive programme of research examining the pattern of routine measures of BMI within primary care in England over time and associations with survival and health outcomes.
The overarching aim of the PhD will be achieved by the following objectives:
- Investigate the pattern of missingness of BMI in primary care records and develop optimal methods for imputation.
- Define the pattern and stability of BMI over time and across age, sex, deprivation and ethnicity
- Undertake a series of survival models investigating the association between BMI and different morbidity/mortality outcomes, exploring interactions by age, sex, ethnicity and deprivation.
The student will work within the Leicester Real World Evidence Unit with access to linked primary care data through the Clinical Practice Research Datalink (CPRD) dataset, as well as national datasets accessed through different Trusted Research Environments (TREs). The project objectives will be addressed by using a diversity of statistical methods, including imputation, time series regression modelling and flexible parametric survival modelling.
The project has been designed to add value to existing programmes of research funded by Health Data Research UK and our industry partners. It also aligns to the aspirations of the NIHR Leicester BRC, consolidating collaboration across the Lifestyle theme with data innovation and ethnic health. The project will help support the continuation or expansion of this funding in the future.
Yates T, Summerfield A, Razieh C, Banerjee A, Chudasama Y, Davies MJ, Gillies C, Islam N, Lawson C, Mirkes E, Zaccardi F. A population-based cohort study of obesity, ethnicity and COVID-19 mortality in 12.6 million adults in England. Nature communications. 2022 Feb 2;13(1):1-9.
This 3-year PhD Studentship provides:
- UK tuition fee waiver
- Annual stipend at Research Council rates (£17,668 for 2022/23. TBC for 2023/24)
Applicants are required to hold/or expect to obtain a UK Bachelor's Degree 2:1 or better (or overseas equivalent) in a relevant subject.
MSc in a relevant subject is desirable
The University of Leicester English language requirements apply where applicable.
- Professor Tom Yates firstname.lastname@example.org
- PGR Admissions email@example.com
How to apply
How to apply
To submit your application, please use the 'Apply' button at the bottom of the page and select September 2023 from the dropdown menu.
Include with your application:
- Personal statement explaining your interest in the project, your experience and why we should consider you
- Degree Certificates and Transcripts of study already completed and if possible transcript to date of study currently being undertaken
- Evidence of English language proficiency if applicable
- In the reference section please enter the contact details of your two academic referees in the boxes provided or upload letters of reference if already available.
- In the funding section please specify that you wish to be considered for the Diabetes Research Centre studentship
- In the research proposal section please provide the name of the project supervisors and project title (a proposal is not required)
Open to UK (Home) applicants only.
*Applicants holding EU Settled or Pre-settled status:
Once you have submitted your application please email a UK government share code starting with S to firstname.lastname@example.org so that we can verify your status. Include your application number.