Phenotyping peripheral blood eosinophils in severe asthma and EGPA

Qualification: PhD

Department: Respiratory Sciences

Application deadline: 1 September 2020

Start date: 11 January 2021

Overview

Supervisors

Professor Salman Siddiqui and Dr Adam Wright

Project description

This studentship is funded by the College of Life Sciences and is placed within the supportive and nurturing environment provided by the Department of Respiratory Sciences, the Leicester Biomedical Research Centre and the Leicester Precision Medicine Institute.

You will receive financial backing and the support of an inclusive and collaborative research culture - enabling you to realise your potential. Additional opportunities to link the program to other relevant University groups including the Institute for structural biology and core biotechnology services will be available. 

The PhD project will involve identifying and characterising the  heterogeneity of circulating eosinophils in severe asthma and related conditions such as Eosinophilic granulomatosis with polyangitis (EGPA). Eosinophils are a key effector cell in these conditions, however little is known about the heterogeneity of these cells and their contribution towards eosinophilic lung disease. Understanding heterogeneity is important and may enable both greater mechanistic understanding of existing eosinophil targeted therapies (anti-IL5) and the development of new orally bio available inhibitors of eosinophil function.

Deeply phenotyped patients from the adult severe asthma services will undergo detailed profiling of blood eosinophils using a range of techniques – such as multicolour flow cytometry, ex vivo functional assays and transcriptional profiling using molecular methods. 

Funding

Funding

This 3 year PhD Studentship includes:

  • UK/EU tuition fee waiver
  • An annual Stipend at UKRI rates (£15,285 for 2020/21)

Entry requirements

Entry requirements

UK Bachelor Degree with at least a 2:1 in Biological sciences, molecular biology or overseas equivalent.

Expertise in multi-colour flow cytometry, RNAseq analysis would be advantageous.

University of Leicester English language requirements apply (where applicable).

Informal enquiries

Informal enquiries

Project enquiries:

Application enquiries:

How to apply

How to apply

To apply, please use the 'Apply' button at the bottom of the page.

Select January 2021 from dropdown menu.

Within the application form, please:

  • Specify that you wish to be considered for a College of Life Sciences 2021 Studentship
  • Include the project title
  • Include the names of the project supervisors

Eligibility

Eligibility

UK/EU applicants only.