Principal investigators

Glenn Burley profileProfessor Glenn A. Burley

Glenn A. Burley is Professor of Chemical Biology at the University of Strathclyde. Glenn was awarded a Bachelor of Medicinal Chemistry (Hon. I, 1996) and a PhD in Organic Chemistry (2000) from the University of Wollongong, Australia. After a post-doctoral stay at the Fullerene Science Centre at the University of Sussex (2001-2003), Glenn was awarded an Alexander von Humboldt Fellowship to work with Thomas Carell at the University of Munich (2004-2006). Glenn began his independent career as an EPSRC Advanced Fellow (2007) at the University of Leicester, before moving to Strathclyde in 2011. Research interests of Glenn’s group focuses on developing molecular tools and technologies to probe gene expression.

Alasdair Clark profileDr Alasdair Clark

Dr Clark is a Senior Lecturer working in the James Watt School of Engineering at the University of Glasgow.  After obtaining his undergraduate degree in Applied Physics from the University of Strathclyde, Dr Clark moved to the University of Glasgow to pursue a PhD in Nano-Plasmonics. On completion of his PhD studies he took a short Post-Doc appointment at the University of California, Berkeley, before returning to Glasgow to start the Nanophotonic Devices research group.

Cyril Dominguez profileDr Cyril Dominguez

Dr Dominguez is a structural biologist interested mainly in protein-RNA interactions involved in the regulation of alternative splicing. He obtained his BSc and MSc in Biochemistry from the University of Aix-Marseille (France). In 2000, Dr Dominguez moved to the University of Utrecht (The Netherlands) to do a PhD under the supervision of Rob Kaptein, Rolf Boelens and Alexandre Bonvin. During that time, Dr Dominguez developed a novel protein-protein docking software, HADDOCK. After his PhD in 2004, he joined the laboratory of Fred Allain at the ETH Zurich (Switzerland) where he studied the interaction between the splicing factor hnRNP F and G-tract RNAs. In 2010, Dr Dominguez obtained an MRC Career Development Award Fellowship to initiate his own research programme at the University of Leicester. His research focused on i) the interaction between the splicing factor Sam68 and its target RNA and ii) the role of RNA G-quadruplexes in the regulation of alternative splicing. In 2015, Dr Dominguez became a lecturer at the University of Leicester.

Ian Eperon profileProfessor Ian Eperon

Professor Eperon studied Biochemistry at the University of Bristol, from 1974 to 1977. The department had considerable strengths in enzyme kinetics, crystallography, nucleic acids and bioenergetics, all of which shaped his view of biochemistry as an essentially molecular and quantitative science. Professor Eperon’s PhD research was done with Fred Sanger at the MRC LMB in Cambridge, starting just as he was publishing the dideoxy sequencing method for DNA that would revolutionize biological science. Most modern sequencing methods still rely on the principles of using extension by DNA polymerase from a primer with a defined 5’ terminus, established in Sanger's papers in 1975 and 1977. Professor Eperon worked on cloning and sequencing human, bovine and trypanosome mitochondrial genomes. 

Professor Eperon obtained a fellowship in 1981 to work with Joan Steitz at Yale University on the newly-discovered process known as RNA splicing. In 1984, he was appointed as a lecturer in Leicester. This was followed later by appointments as a Reader and then Professor of Biochemistry.

Andrew Hudson profileProfessor Andrew J. Hudson

Professor Andrew J. Hudson is a biophysicist with a track record for interdisciplinary collaborative research. He graduated with a first class Bachelor’s degree in Chemistry from the University of Oxford and a PhD in Chemical Physics from the University of Toronto, where he worked with Professor John Polanyi, FRS. AJH has worked for a number of companies in the optical technologies industry, EFOS Inc. (Mississauga, Canada), EXFO Inc. (Mississauga, Canada), and Novx Systems (Richmond Hill, Canada).

On the theme of single molecule studies, he has worked on particle tracking mechanisms of COPII complexes in live cells (Traffic 2008, 9, 1850-1866) and applied single molecule fluorescence spectroscopy to study the conformational dynamics of forked-DNA (PLoS One 2012, 7, e29703) and the reaction mechanisms of RNA splicing complexes (Nucleic Acids Res, 2012, 40, 6850-6862; ibid 2017, 45, 2051-2067; ibid 2018, 46, 2145-2158). He has also applied Raman microspectroscopy to monitor haem proteins in live cardiomyocytes (J. Royal Soc. Interface 2015, 12, 20141339) and determine mechanisms for how small molecules (NO, CO) confer cardioprotection via their interactions with haem proteins (Anal. Chem. 2015, 87, 10605-10612). AJH has expertise with developing hybrid techniques: for example, the integration of holographic optical tweezing and spectroscopy (Nanoscale, 2016, 8, 16395-16404; Scientific Reports, 2017, 7, 8589), and microfluidics and spectroscopy (ACS Nano, 2015, 9, 9718-9730; ChemSelect, 2017, 2, 3342–3346); both of which are being used for single cell studies in his laboratory. AJH has recently published the first results from the deployment of a genetically-encoded sensor to measure exchangeable (or regulatory) haem in live cells using fluorescence lifetime imaging (PNAS accepted).