Laboratory Research Project

Module code: MB7404

Module Outline

One of the most valued features of this MSc course is the laboratory research project, in which you put your newly acquired practical skills and knowledge to the test. For six months, you work as a member of a dedicated research team, designing and conducting your own experiments, culminating in the production of a dissertation. Recent titles offered on our previous course (MSc in Molecular Pathology and Toxicology) which are relevant to this degree include:

  • Biomarkers of bladder cancer in human urine
  • Use of human adult stem cell models for assessing the efficacy of cancer chemopreventive and chemotherapeutic agents
  • Translating prognostic biomarkers in melanoma
  • Monitoring the circulating cancer genome for patient follow up
  • Lung cancer detection in sputum
  • Development and application of PCR assays for detection of cancer driver mutations

Some of the data generated from these previous projects have been published:

Britton RG, Horner-Glister E, Pomenya OA, Smith EC, Denton R, Jenkins PR, Steward WP, Brown K, Gescher A, Sale S (2012). 'Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents.' Eur. J. Med. Chem. 54: 952-958 doi:10.1016/j.ejmech.2012.06.031

Al-Salmani K, Abbas HHK, Schulpen S, Karbaschi M, Abdalla I, Bowman KJ, So KK, Evans MD, Jones GDD, Godschalk RW, Cooke MS (2011). 'Simplified method for the collection, storage, and comet assay analysis of DNA damage in whole blood.' Free Radical Biol. Med. 51: 719-725. doi:10.1016/j.freeradbiomed.2011.05.020

Sayan AE, Griffiths TR, Pal R, Browne GJ, Ruddick A, Yagci T, Edwards R, Mayer NJ, Qazi H, Goyal S, Fernandez S, Straatman K, Jones GD, Bowman KJ, Colquhoun A, Mellon JK, Kriajevska M, Tulchinsky E. (2009). 'SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer.' Proc. Natl. Acad. Sci. U S A 106: 14884-14889