Research Project

Module code: MB7205

Module Outline

You choose your laboratory research placement from projects covering a broad range of disciplines involving molecular genetics and a variety of organisms. You become part of an active research group employing modern approaches and technologies to solving significant research questions.

Projects undertaken by Molecular Genetics students have included:

  • Characterising actively transducing L1 retrotransposons in humans
  • DNA methylation and photoperiodism in the wasp N. vitripennis
  • Copy number variation in haptoglobin and haptoglobin-related protein and their association with human sleeping sickness
  • Mitochondrial stress and autophagy in a Parkinson’s model
  • Effects of folic acid deficiency on genome stability in mice
  • Characterisation of the PapsFIL gene in the opium poppy
  • Effect of bottleneck on phase variable genes of C. jejuni
  • Functional genomics of Bak1 polymorphisms and human platelets

Assessment of the research project is in three parts, based on your research performance, a dissertation you write about your research and a seminar you will present at the end of the project.

Project work by some MSc Molecular Genetics students has been published:

  • Borg M, Brownfield L, Khatab H, Sidorova A, Lingaya M, Twell D. (2011) The R2R3 MYB transcription factor DUO1 activates a male germline-specific regulon essential for sperm cell differentiation in Arabidopsis. Plant Cell 23, 1-16.
  • Mendez-Bermudez A, Hidalgo-Bravo A, Cotton VE, Gravani A, Jeyapalan JN, Royle NJ. (2012). The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres. Nucleic Acids Research 40, 10809-10820
  • Ray A, Rahbari R, Badge RM (2011) IAP Display: A Simple Method to Identify Mouse Strain Specific IAP Insertions. Molecular Biotechnology 47, 243-252.
  • Vosnakis N, Maiden A, Kourmpetli S, Hands P, Sharples D, Drea S. (2012) A filamentous flower orthologue plays a key role in leaf patterning in opium poppy. The Plant Journal 72, 662–673
  • Watkins RJ, Patil R, Goult BT, Thomas MG, Gottlob I, Shackleton S. (2013) A novel interaction between FRMD7 and CASK: evidence for a causal role in idiopathic infantile nystagmus. Hum. Mol. Genet. first published online February 12, 2013 doi:10.1093/hmg/ddt060


  • Research Performance (35%)
  • Research Report (57%)
  • Research Seminar (8%)