5. Independent Laboratory Research Project

Module code: MB7006

Module co-ordinator: Dr Sally Prigent

Module Outline

This module comprises a full-time, eight-month research project placement: six months of lab work and then two months for writing the dissertation and project presentation. The student's placement may be at an industrial research laboratory or a cancer research institute or within the University of Leicester itself.

Students will select a project according to your interest from a wide range of cancer-related topics and contribute to the work of a research group. Some examples of projects undertaken by recent students include:

During their project they will learn how to design and conduct hypothesis-driven research using state-of-the-art techniques. They will also gain experience of how to critically interpret scientific literature and how to use effective written and oral communication to present their data.

Learning

  • Six months full-time research project
  • One two-hour tutorial
  • Attendance at College seminars

Assessment

  • Laboratory performance (35%)
  • Dissertation, 15,000 words (55%)
  • Project seminar (10%)

Published projects

Some previous MSc projects have led to Leicester students co-authoring publications in peer-reviewed journals:

  • Lam D, Shah S, de Castro IP, Loh S, Martins LM. (2010). Drosophila happyhour modulates JNK-dependent apoptosis. Cell Death and Disease, Aug 10; 1: e66. doi:10.1038/cddis.2010.44
  • Muskett FW, Thouta S, Thomson SJ, Bowen A, Stansfeld PJ, Mitcheson JS. (2011). Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain. J. Biol. Chem., 286, 6184-91. doi:10.1074/jbc.M110.199364
  • Al-Salmani K, Abbas HH, Schulpen S, Karbaschi M, Abdalla I, Bowman KJ, So KK, Evans MD, Jones GD, Godschalk RW, Cooke MS. (2011). Simplified method for the collection, storage and comet assay analysis of DNA damage in whole blood. Free Radic. Biol. Med., 51, 719-25. doi:10.1016/j.freeradbiomed.2011.05.020
  • Prosser SL, Samant MD, Morrison CE, Baxter JE, Fry AM. (2012) Oscillation of APC/C activity during cell cycle arrest drives centrosome amplification. J. Cell Sci., 125, 5353-5368. doi:10.1242/jcs.106096