Leicester Institute of Structural and Chemical Biology

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New approach provides potential vaccine and treatment for Alzheimer’spicture of peptide vaccine on its own and in a protein binding pocket

A promising new approach to potentially treat Alzheimer’s disease – and also vaccinate against it – has been developed by a team including LISCB scientists.

Both the antibody-based treatment and the protein-based vaccine developed by the team reduced Alzheimer’s symptoms in mouse models of the disease. The research is published today in (Molecular Psychiatry).

The work is a collaboration between researchers at the University of Leicester, the University Medical Center Göttingen and the medical research charity LifeArc.

Professor Mark Carr added: “While the science is currently still at an early stage, if these results were to be replicated in human clinical trials, then it could be transformative. It opens up the possibility to not only treat Alzheimer’s once symptoms are detected, but also to potentially vaccinate against the disease before symptoms appear.”

The researchers are now looking to find a commercial partner to take the therapeutic antibody and the vaccine through clinical trials.

The article will be available following publication at: https://www.nature.com/articles/s41380-021-01385-7

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