Clinical Academic Training

Surgery

Consultants hosting AF trainees within the speciality of surgery.

Professor Matt Bown

Clinical research

I have a broad research portfolio of projects funded by the British Heart Foundation and National Institute for Health and Care Research. These include laboratory research in aortogenomics and clinical research in aneurysm screening.  Our research is focused on the management of abdominal aortic aneurysm and peripheral arterial diseases and spans a wide range of projects from genomics and data science through to clinical trials and other applied research.  My wider research group includes clinical academics working on clinical trials in all aspects of vascular surgery and health data science approaches to studying the outcomes of aneurysm screening programmes.

Professor Gavin Murphy

Clinical research

Post surgery organ failure; Frailty;Clinical trials; Data science; Systems biology and multi-omics. Our research is focused on the development of new strategies for the prevention of organ injury in the acute setting including cardiac surgery, critical care and ECMO.  The cardiac surgery research group is composed of linked clinical trials and laboratory science teams that undertake clinico-experimental early phase translational research.

Mr Tim Rattay

Clinical research

Breast cancer is the most common cancer in the UK, accounting for over 50,000 new cases per year. Thankfully, the vast majority of breast cancers are treatable. Approximately 800,000 women previously diagnosed with breast cancer were estimated to be alive in the UK in 2020 - a figure predicted to rise to over 1.2 million by 2030.

Surgery and radiotherapy are the most commonly used breast cancer treatments. However about 1 in 5 patients will experience moderate to severe side-effects (toxicity) from treatment.  My main research interests are in the prediction and reduction of treatment toxicity in the breast.  My research is focused on validating clinical and molecular predictors of toxicity as well as discovering new predictors through genome-wide association studies, Big Data and artificial intelligence (AI) approaches.  I also have an interest in applying qualitative research methodology to explore patients’ views on breast cancer treatments and personalised medicine.

Dr Dimitris Papamargaritis

Clinical research

My research focuses on the mechanisms of weight loss and diabetes remission after bariatric surgery and identifying potential treatments for postprandial hyperinsulinaemic hypoglycaemia, a disabling metabolic complication after bariatric surgery. I am currently leading four crossover early phase mechanistic trials (CONTROL, SALT, CARLOTA and BariEx), assessing the effect of different nutritional, lifestyle and pharmacotherapy interventions on gut hormone and insulin secretion after bariatric surgery. These research projects would be suitable for a clinical academic with interest in experimental medicine (including early phase clinical trials) in the area of obesity, cardiometabolic health, type 2 diabetes and bariatric surgery.

Dr Jatinder Minhas

Clinical research

My research endeavours to bridge the gap between technical studies in cerebrovascular physiology (particularly acute intracerebral haemorrhage), and delivery of clinical stroke care and research. I strongly believe this niche is vital for delivering technically excellent and innovative translational programmes of research with the potential to deliver significant improvements in stroke care, in reasonable time frames.

Additionally, I lead and collaborate on analyses of our prospective minor stroke/transient ischaemic attack cohort – answering clinically relevant questions for our local and national stroke populations.

Examples of published aFY lead work previously include:

Cerebrovascular tone and resistance measures differ between healthy control and patients with acute intracerebral haemorrhage: exploratory analyses from the BREATHE-ICH study - PubMed (nih.gov) 

Therapeutic Variation in Lowering Blood Pressure: Effects on Intracranial Pressure in Acute Intracerebral Haemorrhage - PubMed (nih.gov)

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