Consultants hosting AF trainees within the speciality of medicine.

Dr David Adlam

Clinical research

Rare coronary phenotypes leading to acute coronary syndromes.

Cardio-oncology including repurposing antiplatelet drugs for anticancer purposes.

Big data involving linkage of national audits Novel cardiovascular medical devices.

Professor Liz Anderson

Clinical research

I am a regional, national and international leader of interprofessional education aligned to team working and patient safety. I have a range of research projects within medical educational exploring interprofessional simulations, the need for reflection using Portfolios and designing and piloting new learning possibilities in practice, recently bringing together pharmacists and medical students.

Dr Natalie Armstrong

Clinical research

The SAPPHIRE (Social Science Applied to Healthcare Improvement Research) Group in the Department of Health Sciences uses social science theory and methods to undertake research and evaluation in order to improve the quality and safety of healthcare. A developing area of interest in the group is around over-diagnosis and over-treatment, which occur when a diagnosis is ‘correct’ according to current standards but the diagnosis or associated treatment has a low probability of benefiting the patient, and may instead be harmful. We would welcome Academic Foundation Doctors keen to explore this area further either in general terms or as it relates to a particular clinical area.

Dr Jonathan Barratt

Laboratory research

The Leicester IgA nephropathy group study the pathogenesis of this common kidney disease. We use cutting edge molecular and "omics" techniques in in vitro and in vivo models of disease to examine the pathological basis of the disease. We have a proven track record of converting aFY doctors to ACFs in a range of clinical specialities.

Dr Julian Barwell

Clinical research

Research within our department is based around gene mapping rare diseases and reducing inequality of access to Genomic Medicine through strong stakeholder partnerships.

Dr James Burton

Clinical research

The Leicester Cardiorenal Group has a wide range of research projects and opportunities for clinical academics at all levels of training. Our current trials include basic research to look at circulating biomarkers of cardiovascular risk in patients with kidney disease, new imaging techniques to assess cardiac function and interventions to improve patient outcomes. New team members would have a chance to experience all of these areas or to focus on one in particular and to gain insight into clinical academic training within a team that includes Academic Clinical Fellows and current PhD students.

Professor Simon Conroy

Clinical research

Our group's ambition is to improve outcomes for frail older people by embedding evidence based medicine into clinical practice. Our service developments and research assess different models of care for frail older people, testing feasibility as well as clinical and cost-effectiveness. We aim to make an impact, for example: a 2016 survey of English hospitals found that 56/98 (57%) respondents were aware of one or more Leicester urgent care initiatives, 44% specified Leicester schemes as influencing their service and 21% had implemented a Leicester initiative; our 2012 publication the Silver Book has been downloaded over 200,000 times.

Professor Martin Dyer

Clinical research

We are developing and assessing new precision medicines for the treatment of lymphoid malignancies, using both in vitro and in vivo modelling to design combinations to take into the clinic. We are also running many early phase clinical trials with novel small molecules and antibody constructs.

My group is focused on developing and assessing new targeted therapies for B-cell malignancies, utilising a variety of techniques to assess mechanisms of action and to develop mechanism-based synergistic combinations of precision medicines. We also perform a wide of range of early phase clinical trials using novel small molecules and antibody constructs in the Hope Clinical Trials Facility in the Osborne building

Please see our recent publications.

Dr Rachael Evans

Clinical research

I have three main areas of research from which projects for an academic FY could be completed: 1) Understanding the syndrome of chronic breathlessness, 2) Exercise as a therapy for chronic disease, 3) Advanced COPD: understanding clinical aspects of the disease and management. We also have outcome data from improvements to our acute NIV service. Projects could also include a systematic review and meta-analysis.

Professor Dean A. Fennell

Clinical research

The goal of this project will be to explore the genomic architecture and evolution of mesothelioma as a basis for novel therapeutic target discovery and understanding the mechanisms that underpin drug resistance and exceptional response.

This translational research project will be linked to the BLF funded, Leicester led MEDUSA/MIST programme, which involves a network of investigators across UoL/UHL (cancer, respiratory, genetics/genomics, LPMI).

Leicester is an internationally recognised leader in mesothelioma clinical and translational research, and the AFD would be involved in a cutting edge research likely to support a high impact publication and significantly increase our understanding of natural history of mesothelioma (in common with ongoing developments in the related programme, TraceRx).

Dr Mamta Garg

Clinical research

Haematological Cancers - Myeloma and related disorders.

Myeloproliferative neoplasm.

Immune Hematology.

Dr Laura Gray

Clinical research

I am a medical statistician who works in the clinical area of diabetes. I could supervise a clinician who is interested in developing their knowledge of epidemiology, medical statistics, systematic review and meta analysis applied to diabetes. I would support them in developing their statistical skills and then in completing either a secondary analysis of a completed study or a small systematic review.

Dr Neil Greening

Clinical research

I have a major interest in patients with advanced COPD, in particular the effects of exacerbations and hospitalisation on them.

We have a complex COPD cohort that is jointly run as apart of the clinical service and observational research, who undergo a comprehensive respiratory assessment.

I am also part of a large observational study looking at the effects of hospitalisation on long term outcome, which includes novel measures of airflow obstruction.

Dr Kate Hodgson

Clinical research

Outcome data from Stem Cell Transplant Programme - lots of prospectively collected data in need of analysis Microbiology in haematology - with Nelun Perera, looking at bacterial and fungal infection and management in haematology patients.

Dr Graham Johnston

Clinical research

We are commencing the clinical stage of our large MRC funded clinical trial of a novel scar treatment in healthy volunteers (SSCART) on October 2017.

We are looking for a high calibre and keen doctor to work with Professor Pullar, Dr Johnston and our MRC Research Fellow on a unique clinical project to assess the effectiveness of a novel anti-scarring treatment scar gel on fresh wounds in healthy human volunteers.

This busy and exciting study will be suitable for anyone considering an academic career in the surgical specialities, plastic surgery or dermatology.

You will help identify and recruit healthy volunteers, assist with production of surgical wounds and monitoring for adverse events as well as regular clinical assessment of the resultant scars.

You will be based at the Research Space at the LRI and will gain experience in clinical study design and execution, scar formation and wound healing and the clinical and objective assessment of scarring and wounding as well as the pathophysiological mechanisms involved in scarring. There will be opportunity to join the wider dermatology team for clinical and surgical training during your attachment.

Given the calibre of the team you can expect to publish in high impact journals and have the opportunity to present at major wound and scar meetings.

Dr Roger Kockelbergh

Clinical research

Urological cancer epidemiology.

Aim to define the risk of recurrence in non muscle invasive bladder cancer.

Method using routinely collected NHS data to pilot locally and describe nationally the risk of recurrence by area of residence.

Dr Nigel Langford

Clinical research

Review of prescribing habits in the elderly with consideration of overprescribing and benefits regarding stopping secondary prophylactic medication. Project consist of review of literature into prescribing stopping rules, consideration of such rules in real life evaluating patients who have died in the hospital and finally review of nursing home patients admitted to hospital. End outputs will consist of paper to CMG regarding potential savings as well as poster and paper.

Professor Gerry McCann

Clinical research

My research programme is focused on using cardiac MRI and other imaging to better understand cardiovascular disease in vivo, developing and assessing novel treatments and implementing large multi-centre trials that change clinical practice.

Currently active studies include lifestyle and drug interventions in diabetic cardiomyopathy, imaging and plasma biomarkers in aortic stenosis, validating novel methods of cardiac dysfunction. Studies due to commence include randomised trials in NSTEMI, Aortic stenosis and heart failure with mild-moderately impaired LV function.

My group has published over 60 papers in the last 5 years including JAMA, JACC and European Heart Journal.

Dr Shafi Malik

Clinical research

I have an interest in clinical epidemiology and clinical research, my current areas of research are: barriers to live donation in ethnic minorities - donation in ethnic minorities is very low and hence it's imperative we understand the reasons behind this. This project has both a qualitative and quantitative research element, we have completed a study in the Sikh community in Leicester and now plan to target other ethnic minorities in East Midlands to understand the barriers to donation.

Digital intervention to promote live donation - intervention that will be culturally specific to each community and includes a validation phase.

Cognition - cognition improves post renal transplant although in some it may worsen. We will soon be starting a longitudinal study of cognitive function and frailty in renal transplant patients.

GFR measurement in different population groups and post live donation is an understudied area and we will soon be starting a research project related to this.

Dr Arumugan Moorthy

Clinical research

Our main area of research is in exploring the Ethnic variation of various Rheumatic disease manifestations and drug management including adherence. Spondyloarthropathy is my special interest and we are now keen to explore the cardiovascular risk in this chronic inflammatory condition.

Dr Nicola Royle

Laboratory research

My group is interested in cellular processes that impact on the length and stability of telomeres in somatic cells and in the germ line. Telomeres cap the ends of chromosomes and thus play an essential role in the maintenance of genome stability and cancer avoidance. We have projects that span basic and translational research.

Dr Nainal Shah

Clinical research

I have two areas of clinical research/leadership that FY academic trainee can be part of:

  1. Delirium risk assessment tool
  2. Validation of locally developed delirium assessment tool against NICE recommended tool

Dr Salman Siddiqui

Clinical research

Asthma, COPD, phenotyping, imaging, physiological modelling of disease, airway repair and remodelling.

Dr Alice Smith

Clinical research and laboratory research

Exercise training for kidney transplant recipients. Range of outcome measures including qualitative, PROMs, psychosocial, functional, clinical, cardiovascular, metabolic, immune function, muscle metabolism. Mixture of clinical and laboratory mechanistic approaches. Linked to NCSEM and BRC.

Dr Cordula Stover

Laboratory research

Mouse models of metabolic syndrome.

Mouse models of SLE.

Related in vitro work research group of advanced PhD students.

Happy to host December to March or April to July.

Professor Toru Suzuki

Clinical research

Project will be to understand contemporary approaches and outcomes of aortic services at Glenfield Hospital through audit and registry among other clinical epidemiological approaches. If interested, biomarker studies to identify proteomic/metabolic signatures of aortic disease may also be possible in addition to imaging studies in both patients and in experimental models of aortic disease.

Dr Chris Talbot

Laboratory research

We are seeking to find predictors for adverse reactions to radiotherapy in breast, prostate and lung cancer. The work is part of a European project called REQUITE and involves a interdisciplinary group of clinical oncologists, surgeons, radiologists and geneticists. The project will be a mixture of laboratory and clinical research, including assessing patients for clinical radiotherapy toxicity and carrying out DNA damage assays on their blood samples.

Dr Carolyn Tarrant

Clinical research

The SAPPHIRE (Social Science Applied to Healthcare Improvement Research) Group has expertise in qualitative methods and health care improvement, with particular interests in acute care, maternity care, healthcare associated infections, and measurement for improvement. A qualitative project would be available to explore junior doctors' experiences of working in acute care at weekends, in relation to their role and professional development; we would also be happy to discuss other possible research topics.

Professor Anne Thomas

Laboratory research

The Academic Foundation doctor would work with myself and Professor Jacqui Shaw collecting longitudinal patient samples for CTDNA analysis to help stratify their treatment. This is really cutting edge work and the doctor would be able to work in a very dynamic but supportive lab environment with support by Hope unit staff. The patients will either be GI or breast and we would confirm this nearer the appointment.

Dr Pradeep Vasuedevan

Clinical research

Phenotyping and Genotyping of AHDC1/ Xia-Gibbs syndrome (Complimentary analysis project from DDD)

Audit project: Fetal medicine and prenatal genetics.

Dr Ajay Verma

I have interests as a clinician and a clinical researcher in inflammatory bowel disease, colorectal cancer and advanced endoscopy techniques including ERCP. A list of Dr Verma's previous research projects is available.

I am currently working with a HIV/GUM Consultant colleague on a HIV Screening project for admissions to Kettering General Hospital and would welcome Academic Foundation trainee assistance with this.