Clinical Academic Training

Vascular Surgery

Prevention of acute kidney injury in patients undergoing vascular surgery 

  • Thanos Saratzis
  • Professor Matt Bown

Peripheral Arterial Disease (PAD) affects a fifth of people over the age of 55. It is the leading cause of major limb amputation and its prevalence is increasing, due to the increase in the prevalence of diabetes, obesity, and lifestyle choices. Most patients with symptomatic PAD are offered revascularisation in the form of surgery, endovascular treatment, or a hybrid approach combining the two. Acute Kidney Injury (AKI) and long-term renal decline are the most common complications of surgical and/or endovascular treatments for PAD. They are associated with higher mortality, morbidity, and decreased quality-of-life both acutely and over the long-term. There is still no proven method in order to prevent short- and long- term renal injury in this patient population.

The University is internationally renowned for cardiovascular and vascular surgery research. We are supported by world-class staff and infrastructure, including a NIHR Biomedical Research Centre (BRC). The vascular surgery group has specific expertise in applied vascular research, most of it NIHR-funded (£4.5 million in vascular NIHR research income since 2019). We have been researching the epidemiology, mechanisms, implications, and prevention of renal injury in a vascular surgery setting for the last few years. Mr Saratzis and Professor Bown have a strong track record of supervising ACFs and PhDs, and have authored 321 high-impact publications.

The ACF will join an established interdisciplinary programme of research involving clinicians and methodologists. Their project will involve testing a complex intervention designed to prevent AKI in the setting of endovascular surgery. We hope this will lead to a large randomised controlled trial. Research training will be bespoke, including statistics, qualitative research methodology, and trial design.

Medical Education

If you are interested in progressing an educational research project within the speciality please visit the medical education project page

 

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