National Cardiac Surgery Research Trials Initiative

Project Aims and Objectives

In 2019, James Lind Alliance Priority Setting Partnership in Adult Cardiac Surgery identified the Top 10 research priorities for patients, carers and clinicians  

Our next step is to translate these research priorities into a programme of clinical trials that address the most important research questions.

This process will be taken forward, by nine new Clinical Study Groups (CSG) led by interdisciplinary teams composed of members of the public, health services researchers and clinicians.

CSG1 Long Term Outcomes and Quality of Life

  • Clinician: Mark Petrie
  • Health Services Researchers: Richard Evans, Linda Sharples and Sara Schroter
  • Patient and Public Representatives: Sarah Murray, Deb Smith and Jara Weinkauf
  • Cardiothoracic Interdisciplinary Research Network: Shagorika Talukder
  • See more about our long term outcomes and quality of life.

CSG2 Prehabilitation

  • Clinicians: Sally Singh and John Cleland
  • Health Services Researchers: Rod Taylor and Alex McConnachie
  • Patient and Public Representative: Hannah Drummond, Alison Banayoti and Jenny Camaradou
  • Cardiothoracic Interdisciplinary Research Network: Georgia Layton
  • See more about prehabilitation.

CSG3 Heart Valve Interventions

  • Clinicians: Gerry McCann, Rana Sayeed and Saul Myerson
  • Health Services Researchers: Ines Rombach and Tom Treibel
  • Patient and Public Representatives: Paul Haywood and Wil Woan
  • Cardiothoracic Interdisciplinary Research Network: Nathan Tyson
  • See more about heart valve interventions.

CSG4 Minimally Invasive, Hybrid and Percutaneous Techniques

  • Clinicians: Enoch Akowuah and Hunaid Vohra
  • Health Services Researchers: Rebecca Maier and Carol Gamble
  • Patient and Public Representatives: Wil Woan, Alan Keys and Peter Every
  • Cardiothoracic Interdisciplinary Research Network: Amer Harky
  • See more about minimally invasive, hybrid and percutaneous techniques.

CSG5 Organ Protection

  • Clinicians: Andrew Klein, Gudrun Kunst and Graham Cooper
  • Patient and Public Representatives: Carol Pellowe and Irene Leeman
  • Cardiothoracic Interdisciplinary Research Network: Jason Ali
  • See more about organ protection.

CSG6 Atrial Fibrillation

  • Clinicians: Barbara Casadei and Gianni Angelini
  • Health Services Researchers: Barnaby Reeves and Chris Rogers
  • Patient and Public Representative: Gil Wheeler
  • Cardiothoracic Interdisciplinary Research Network: George Gradinariu
  • See more about atrial fibrillation.

CSG7 Infection Prevention

  • Clinicians: Melissa Rochon, Luke Rogers and Ricky Vaja
  • Health Services Researchers: Judith Tanner, Shaun Barber and Cassandra Brookes
  • Patient and Public Representative: Jeremy Dearling
  • Cardiothoracic Interdisciplinary Research Networks: Ricky Vaja and Luke Rogers
  • See more about infection prevention.

CSG8 Data Science

  • Clinicians: Chris Gale and Cathie Sudlow
  • Health Services Researchers: Deborah Stoken and Amanda Farrin
  • Patient and Public Representative: Eric Deeson
  • Cardiothoracic Interdisciplinary Research Network: David Bleetman
  • See more about data science.

CSG9 Management of Frailty, Sarcopenia and Chronic Conditions

Aims and Objectives

  • To develop a core leadership composed equally of members of the public, research methodologists, and clinicians
  • To host a series of webinars with representation from all of the relevant stakeholders who will translate the JLA PSP priorities into research questions
  • To define areas of uncertainty, knowledge gaps, and evidence of equipoise, to provide the rationale for a programme of clinical research that address key priorities
  • To create an environment where researchers can network with patients and research methodologists from individual Clinical Trials Units. This will enable the CSG’s to develop high quality funding applications for clinical trials where these are required
  • To develop a patient and public involvement group for each CSG, in partnership with the BHF Cardiovascular Research Collaborative. This will provide a voice for patient groups and ensure that advocacy carries through to clinical study design and ultimately to dissemination
  • To develop a communications strategy, with members of the public in key advocacy roles, to ensure that these research priorities are reflected in ongoing research commissioning calls
  • To collaborate where possible with similar initiatives in other countries to maximise the impact and generalisability of the research findings

This initiative will utilise the unique opportunities offered by the new BHF Data Science Centre to develop novel, efficient, pragmatic trial designs, as well as the networking opportunities offered by the BHF Cardiovascular Research Collaborative Microsoft Teams platform.

The ultimate goal of this initiative will be to develop a national consortium of stakeholders who can deliver a portfolio of high-quality clinical trials to inform best practice in adult cardiac surgery.