Respiratory Sciences
Microbial Sciences
- Interface between bacterial physiology and human infections, principally those involving the gastrointestinal tract and tuberculosis
- Definition of the factors impacting expression of immunity in the lung, particularly tuberculosis
- The role of early innate events in driving coordinated immune responses
- The role of cytokines and chemokines in initiation, expression and regulation of immunity
- The role of lymphocyte priming, differentiation and migratory capacity in prolonged expression of immunity
- The role of the inflamed environment in regulating the expression of immunity
- Studies into microbial endocrinology
- Relationship between stress and stress hormones and the progress of human and animal infection
- Lipid bodies of pathogenic bacteria, in particular Mycobacterium tuberculosis
- Spectroscopic methods to monitor bacterial adaptation
- Molecular mechanisms of bacterial dormancy and resuscitation
- Role of mycobacterial serine-threonine kinases in growth, cell wall remodelling and dormancy
- Antimicrobial tolerance
- Biomarkers of non-replicating persistence
- Bacterial sensory perception and signal transduction
- Regulation of bacterial metabolism (Mycobacterium tuberculosis)
- Diagnosis of latent and active TB
- Migrant health
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Non-culture detection of mycobacteria in the environment to understand the metabolic configuration and respiratory state associated with their capacity to survive and persist
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Investigation of phenotypic development in NTM as a response to challenging environments with an emphasis on metabolic remodelling and respiration
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Development of constraints-based genome scale models of mycobacteria to understand bacterial fitness within the context of challenging environments using the COBRA toolbox and MATLAB
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The interaction between the environment and mycobacteria during aerosolization to better understand what factors are important for airborne transmission. In this regard, we are developing tools to quantify environmental parameters using low-cost sensors based on a single-board computer
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Airflow measurement and computational fluid dynamic modelling of experimental aerosol exposure to predict lower airway particulate deposition.
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Production engineering of an anatomically realistic mouse training device for intravenous and intraperitoneal injection skill development
- Molecular changes that occur during initiation of the classical and lectin pathways of complement activation
- Characterising the interactions between components that trigger complement activation
- Molecular analysis of bacterial virulence determinants of important human pathogens such as Klebsiella pneumoniae and Streptococcus pneumoniae.
- Understanding in vivo survival mechanisms of microbes
Respiratory Sciences
- Use of translational bench-to-bedside research to identify novel therapeutic approaches for the treatment of chronic obstructive pulmonary disease
- Interface between bacterial physiology and human infections, principally those involving the gastrointestinal tract and tuberculosis
- Pathophysiology of asthma with a particular focus on ion channels and mast cell-airway smooth muscle
- Immunopathogenesis of airway disease namely asthma, chronic obstructive pulmonary disease and chronic cough
- Definition of the factors impacting expression of immunity in the lung, particularly tuberculosis
- The role of early innate events in driving coordinated immune responses
- The role of cytokines and chemokines in initiation, expression and regulation of immunity
- The role of lymphocyte priming, differentiation and migratory capacity in prolonged expression of immunity
- The role of the inflamed environment in regulating the expression of immunity
- T-cell function in respiratory disease, in particular asthma and Chronic Obstructive Pulmonary Disease
- Development and function of human Innate Lymphoid Cells (ILCs)
- Airway epithelial cell biology especially the role of epithelial ion channels and their impact on mucociliary clearance in conditions like asthma, cystic fibrosis and chronic obstructive pulmonary disease
- Lipid bodies of pathogenic bacteria, in particular Mycobacterium tuberculosis
- Spectroscopic methods to monitor bacterial adaptation
- Ex vivo and in vitro studies of lung and liver disease
- Use of structural biology methods to understand disease mechanisms and develop new therapies
- Interstitial lung disease, inflammation and fibrosis
- Alpha1-antitrypsin deficiency and the serpinopathies
- Misfolding and conformational diseases
- Epidemiology of latent and active tuberculosis
- Molecular mechanisms of bacterial dormancy and resuscitation
- Role of mycobacterial serine-threonine kinases in growth, cell wall remodelling and dormancy
- Antimicrobial tolerance
- Biomarkers of non-replicating persistence
- Exercise-based rehabilitation (UK and global health)
- Digital health technologies for disease self-management
- Measurement and evaluation of 24-hour movement behaviours (physical activity, sedentary behaviour, sleep)
- Effects of 24-hour movement behaviours on health
- Interstitial lung disease and Idiopathic pulmonary fibrosis
- Ex vivo studies of lung disease
- Pathophysiology of Idiopathic pulmonary fibrosis
- Understanding cellular responses and mechanisms driving tissue remodelling in fibriotic lung disease
Tuberculosis
- Interface between bacterial physiology and human infections, principally those involving the gastrointestinal tract and tuberculosis
- Definition of the factors impacting expression of immunity in the lung, particularly tuberculosis
- The role of early innate events in driving coordinated immune responses
- The role of cytokines and chemokines in initiation, expression and regulation of immunity
- The role of lymphocyte priming, differentiation and migratory capacity in prolonged expression of immunity
- The role of the inflamed environment in regulating the expression of immunity
- Lipid bodies of pathogenic bacteria, in particular Mycobacterium tuberculosis
- Spectroscopic methods to monitor bacterial adaptation
- Epidemiology of latent and active tuberculosis
- Molecular mechanisms of bacterial dormancy and resuscitation
- Role of mycobacterial serine-threonine kinases in growth, cell wall remodelling and dormancy
- Antimicrobial tolerance
- Biomarkers of non-replicating persistence
- Bacterial sensory perception and signal transduction
- Regulation of bacterial metabolism (Mycobacterium tuberculosis)
- Diagnosis of latent and active TB
- Migrant Health
- Non-culture detection of mycobacteria in the environment to understand the metabolic configuration and respiratory state associated with their capacity to survive and persist
- Investigation of phenotypic development in NTM as a response to challenging environments with an emphasis on metabolic remodelling and respiration<
- Development of constraints-based genome scale models of mycobacteria to understand bacterial fitness within the context of challenging environments using the COBRA toolbox and MATLAB
- The interaction between the environment and mycobacteria during aerosolization to better understand what factors are important for airborne transmission. In this regard, we are developing tools to quantify environmental parameters using low-cost sensors based on a single-board computer
- Airflow measurement and computational fluid dynamic modelling of experimental aerosol exposure to predict lower airway particulate deposition
- Production engineering of an anatomically realistic mouse training device for intravenous and intraperitoneal injection skill development