Cardiovascular Sciences
Biomarkers
- Medical Physics
- Diagnostic radiology
- Brain injury and Cerebral Haemodynamics
- Cardiovascular anatomy and physiology
- Laboratory and computational models of blood flow
- Diagnostics and monitoring in Emergency Care
- The role of biological ageing in coronary artery disease
- Investigating the biological mechanism by which telomere length influences cardiovascular risk
- How modulating telomere length affects cellular physiology and response to pro-atherogenic stress
- Investigating the relationship between telomere length and other cardiovascular phenotypes and risk factors
- Genetic regulation of telomere length in humans
- Identification of additional genetic determinants of LTL
- Identification of the functional SNP(s) within each locus and the mechanism by which they impact on gene/protein function and LTL regulation.
- Investigating the biological mechanism by which the Chr2 (ACYP2) and Chr19 (ZNF) influence LTL
- Epigenetic and gene expression changes associated with changes in LTL
- Molecular and cellular mechanisms of cardiovascular ageing
- Oxidative DNA damage and repair in humans
- Mitochondria and cellular oxidative stress
- Signal transduction associated with the following receptor systems as relevant to pain, sepsis and cardiovascular disease
- Classical and non classical (Nociceptin) Opioid receptors
- Vanilloid (TRPV1) receptors
- Urotensin II receptors
- Inflammatory Organ Injury Post Cardiac Surgery
- Blood Management
- Study of the genetic variation underlying cardiovascular disease and related traits via:
- Genome wide association studies
- Genome wide transcriptome analysis
- Mendelian randomisation
- Collapsing statistics
- Runs of homozygosity
- Pathway analysis
- Genome wide Meta-analyses of genetic data
- Whole genome imputation
- Gene-gene interactions
- Work on sex-chromosomes including Y-haplogroups
- Genome wide methylation data
- Autonomic modulation of Electrical Restitution and Ventricular Fibrillation initiation
- Nitric oxide in mediating vagal protection of the heart against VF
- Non-invasive markers of ventricular arrhythmia risk stratification
- Atrial fibrillation - spectral characteristics and catheter ablation
- Electromechanical refinement of multi-site cardiac pacing
- Studies on the role of cardiovascular peptides in heart disease
- The use of hormonal markers for diagnosis and prognosis in heart disease and to determine therapeutic response to various drug treatments
- Use of proteomic technologies in biomarker discovery
- Action potential duration restitution and its role in the genesis of ventricular arrhythmia and sudden cardiac death.
- Heart failure: in particular optimising cardiac resynchronisation therapy.
- Physiological measurement and modelling
- Cerebral haemodynamics, particularly the regulation of cerebral blood flow
- Cardiovascular system regulation, particularly the short-term regulation of arterial blood pressure
Dr Prashanth Patel
- Natriuretic peptides and other biomarkers in heart failure
- Epidemiology of heart failure
- Novel pharmacological therapies in heart failure
- Data linkage as a research tool
- Multicentre trials in heart failure
- Epidemiology and management of acute coronary artery disease
- Aortic diseases (mechanisms/epidemiology/diagnosis/treatment)
- Cardiovascular biomarkers (proteins/metabolites)
- Development of novel non-invasive monitoring modalities in acute illness
- Integration of non-invasive monitoring for early diagnosis in acute illness
- The role of properdin and complement activation in human and experimental sepsis
- The nociceptin system in laboratory models of sepsis, in human sepsis and inflammatory states
- Cardiovascular genetics
- Mechanisms underlying influences of genetic variants on cardiovascular diseases
- Pathogenesis of atherosclerosis
- Roles of proteinases in cardiovascular diseases
Genomics
- Abdominal aortic aneurysms
- Genomics
- AAA growth
- AAA screening
- Data linkage
- How receptors work: mechanistic, functional and structural biology of receptors
- Directed evolution for creating new proteins and understanding protein function and structure
- Cardiovascular protective signalling
- The role of biological ageing in coronary artery disease
- Investigating the biological mechanism by which telomere length influences cardiovascular risk
- How modulating telomere length affects cellular physiology and response to pro-atherogenic stress
- Investigating the relationship between telomere length and other cardiovascular phenotypes and risk factors
- Genetic regulation of telomere length in humans
- Identification of additional genetic determinants of LTL
- Identification of the functional SNP(s) within each locus and the mechanism by which they impact on gene/protein function and LTL regulation.
- Investigating the biological mechanism by which the Chr2 (ACYP2) and Chr19 (ZNF) influence LTL
- Epigenetic and gene expression changes associated with changes in LTL
Dr Giovanni Mariscalco
- For details, please email Dr Mariscalo.
Dr Simon McDonald
- Congenital heart disease and intervention
- Study of the genetic variation underlying cardiovascular disease and related traits via:
- Genome wide association studies
- Genome wide transcriptome analysis
- Mendelian randomisation
- Collapsing statistics
- Runs of homozygosity
- Pathway analysis
- Genome wide Meta-analyses of genetic data
- Whole genome imputation
- Gene-gene interactions
- Work on sex-chromosomes including Y-haplogroups
- Genome wide methylation data
- Cardiovascular genetics
- Role of biological ageing in coronary heart disease
- Understanding the molecular and cellular mechanisms of genetic variants associated with coronary artery disease
- Cardiovascular genetics
- Mechanisms underlying influences of genetic variants on cardiovascular diseases
- Pathogenesis of atherosclerosis
- Roles of proteinases in cardiovascular diseases
Imaging
Ranjit Arnold
- Medical Physics
- Diagnostic radiology
- Brain injury and Cerebral Haemodynamics
- Cardiovascular anatomy and physiology
- Laboratory and computational models of blood flow
- Cerebral blood flow and autoregulation in neurodegenerative diseases, including idiopathic Parkinson’s disease, mild cognitive impairment and dementia syndromes
- Parkinson’s disease
- Haemodynamic mechanisms of post-operative cognitive dysfunction
- Predictors of decline in mild cognitive impairment
- Post-stroke dementia/cognitive decline
- Clinical trials
- The role of cardiac MRI in the management of patients with suspected cardiac disease
- Detection and quantification of subclinical myocardial dysfunction (using novel strain measurement)
- Aortic stenosis- determinants of symptoms and timing of surgery
- Diabetic cardiomyopathy
- Assessment of novel treatments for STEMI and cardiovascular dysfunction/heart failure
- Studies on the role of cardiovascular peptides in heart disease
- The use of hormonal markers for diagnosis and prognosis in heart disease and to determine therapeutic response to various drug treatments
- Use of proteomic technologies in biomarker discovery
- Physiological measurement and modelling
- Cerebral haemodynamics, particularly the regulation of cerebral blood flow
- Cardiovascular system regulation, particularly the short-term regulation of arterial blood pressure
- Blood Pressure and Acute Stroke
- Autonomic Dysfunction and Acute Stroke
- Cerebrovascular Autoregulation and Acute Stroke
- Multi-centre Stroke Trials
- Predicting Disability in an Ageing Population
- Development of novel non-invasive monitoring modalities in acute illness
- Integration of non-invasive monitoring for early diagnosis in acute illness
- The role of properdin and complement activation in human and experimental sepsis
- The nociceptin system in laboratory models of sepsis, in human sepsis and inflammatory states
Intervention
Dr David Adlam
- Rare coronary artery diseases:
- Spontaneous coronary artery dissection (SCAD) and Coronary aneurysms and estasia (CAE)
- Cardio-oncology
- National data linkage studies
- Novel medical devices
- Coronary optical coherence tomography (including as part of minimal invasive autopsy)
- Endocarditis
Dr Aamer Ahmed
- For details, email Dr Ahmed.
- Abdominal aortic aneurysms
- Genomics
- AAA growth
- AAA screening
- Data linkage
- How receptors work: mechanistic, functional and structural biology of receptors
- Directed evolution for creating new proteins and understanding protein function and structure
- Cardiovascular protective signalling
Dr Frances Bu’Loch
- For details, email Dr Bu'Loch.
- Coagulation following injury
- Multi-centre trials in emergency care
- Predictive modeling of outcome following injury
Dr Ffion Davies
- For details, email Dr Davies.
Leonidas Hadjinikolaou
- For details, email Mr Hadjinikolaou.
Dr Victoria Haunton
- Cerebral blood flow and autoregulation in neurodegenerative diseases, including idiopathic Parkinson’s disease, mild cognitive impairment and dementia syndromes
- Parkinson’s disease
- Haemodynamic mechanisms of post-operative cognitive dysfunction
- Predictors of decline in mild cognitive impairment
- Post-stroke dementia/cognitive decline
- Clinical trials
Dr Jan Kovac
- For details, email Dr Kovac.
Dr Giovanni Mariscalco
- For details, email Dr Mariscalo.
- The role of cardiac MRI in the management of patients with suspected cardiac disease
- Detection and quantification of subclinical myocardial dysfunction (using novel strain measurement)
- Potential (lifestyle and pharmacologic) therapies for diabetic cardiomyopathy
- Assessment of novel treatments for STEMI and cardiovascular dysfunction/heart failure
Dr Simon McDonald
- Congenital heart disease and intervention
- Epidemiology of Stroke and TIA
- Anticoagulation for Stroke prevention in Atrial fibrillation
- Effect of oxygen on cerebral haemodynamics
- The prognostic relevance of blood pressure variability
- Inflammatory Organ Injury Post Cardiac Surgery
- Blood Management
Professor Ross Naylor
- Reducing the risks of carotid surgery
- Factors mediating acute changes in carotid plaque morphology
- Aortic graft infection management
- Antiplatelet function during carotid surgery
Professor André Ng
- Autonomic modulation of Electrical Restitution and Ventricular Fibrillation initiation
- Nitric oxide in mediating vagal protection of the heart against VF
- Non-invasive markers of ventricular arrhythmia risk stratification
- Atrial fibrillation - spectral characteristics and catheter ablation
- Electromechanical refinement of multi-site cardiac pacing
Professor Tom Robinson
- Blood Pressure and Acute Stroke
- Autonomic Dysfunction and Acute Stroke
- Cerebrovascular Autoregulation and Acute Stroke
- Multi-centre Stroke Trials
- Predicting Disability in an Ageing Population
Anthanos Saratzis
- Acute and chronic kidney injury after vascular surgery or endovascular intervention (clinical trials and a national cohort study)
- Cardiovascular risk reduction studies in patients with aneurysmal disease
- Qualitative research relating to aneurysm screening and vascular disease
- Literature synthesis in vascular diseases
Professor Rob Sayers
- Pathogenesis and outcome of abdominal aortic aneurysms
- Cardiac arrhythmia and implantable cardiac rhythm management devices (pacemakers and defibrillators)
- Resuscitation science
- Cardiovascular clinical trials
- Aviation medicine and cardiovascular aspects of fitness to fly
- Inflammatory Organ Injury Post Cardiac Surgery
- Endothelial dysfunction post cardiac surgery and miRNA regulation
- Blood Management
Nephrology
- Genetics and epigenetics of IgA Nephropathy
- Role of the innate immune system in IgA Nephropathy
- Novel therapies in IgA Nephropathy
- IgA structure and function
- Lymphocyte trafficking and IgA Nephropathy
- Role of complement in glomerular injury in IgA Nephropathy
- Cellular Mechanisms and novel interventions in proteinuric progressive renal disease and diabetic nephropathy
- Complement pathways in tubulointerstitial disease
- Study of microparticles as novel biomarkers of cardiovascular disease in uraemia
- Community studies of chronic kidney disease and acute kidney injury risk factors, and implementation of novel management strategies
- Mechanisms of left ventricular hypertrophy, inflammation and fibrosis in CKD
- Interventions to improve cardiovascular outcomes in dialysis patients
- Novel biomarkers for the assessment of cardiovascular risk in patients with CKD
Dr Emma Watson
- Therapeutic use of exercise in CKD
- Molecular mechanisms of muscle wasting in human CKD
Protection
- How receptors work: mechanistic, functional and structural biology of receptors
- Directed evolution for creating new proteins and understanding protein function and structure
- Cardiovascular protective signalling
Dr Victoria Haunton
- Cerebral blood flow and autoregulation in neurodegenerative diseases, including idiopathic Parkinson’s disease, mild cognitive impairment and dementia syndromes
- Parkinson’s disease
- Haemodynamic mechanisms of post-operative cognitive dysfunction
- Predictors of decline in mild cognitive impairment
- Post-stroke dementia/cognitive decline
- Clinical trials
Dr Karl Herbert
- Molecular and cellular mechanisms of cardiovascular ageing
- Oxidative DNA damage and repair in humans
- Mitochondria and cellular oxidative stress
Dr Eylem Levelt
Dr Amit Mistri
- Epidemiology of Stroke and TIA
- Anticoagulation for Stroke prevention in Atrial fibrillation
- Effect of oxygen on cerebral haemodynamics
- The prognostic relevance of blood pressure variability
Professor Ross Naylor
- Reducing the risks of carotid surgery
- Factors mediating acute changes in carotid plaque morphology
- Prevention and treatment of Aortic graft infection
- Antiplatelet function during carotid surgery
Dr William Nicolson
- Action potential duration restitution and its role in the genesis of ventricular arrhythmia and sudden cardiac death.
- Heart failure: in particular optimising cardiac resynchronisation therapy.
Professor Iain Squire
- Natriuretic peptides and other biomarkers in heart failure
- Epidemiology of heart failure
- Novel pharmacological therapies in heart failure
- Data linkage as a research tool
- Multicentre trials in heart failure
- Epidemiology and management of acute coronary artery disease
- Cardiac arrhythmia and implantable cardiac rhythm management devices (pacemakers and defibrillators)
- Resuscitation science
- Cardiovascular clinical trials
- Aviation medicine and cardiovascular aspects of fitness to fly